D70N_human-BCHE

General

Gene Locus : human-BCHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : Succinylthiocholine binding Higher Km lower kcat Masson_1997_Biochemistry_36_2266

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : Succinylthiocholine binding

Torpedo_number : 72

Kinetic Parameter : No kinetic parameter

News : No news

Comment :
p.D70N Asp70Asn (p.D98N Asp98Asn in primary sequence with 28 amino-acids signal peptide) Higher Km lower kcat

References (1)

Title : Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase - Masson_1997_Biochemistry_36_2266
Author(s) : Masson P , Legrand P , Bartels CF , Froment MT , Schopfer LM , Lockridge O
Ref : Biochemistry , 36 :2266 , 1997
PubMedID: 9047329