Schopfer LM

General

Full name : Schopfer Lawrence M

First name : Lawrence M

Mail : University of Nebraska Medical Center\; Eppley Institute\; 985950 Nebraska Medical Center\; Omaha\; 68198

Zip Code :

City :

Country : USA

Email : lmschopf@unmc.edu

Phone : +14025596305

Fax :

Website :

Directory :

References (110)

Title : Human butyrylcholinesterase in Cohn fraction IV-4 purified in a single chromatography step on Hupresin - Schopfer_2023_PLoS.One_18_e0280380
Author(s) : Schopfer LM , David E , Hinrichs SH , Lockridge O
Ref : PLoS ONE , 18 :e0280380 , 2023
PubMedID: 36638134

Title : Review: Organophosphorus toxicants, in addition to inhibiting acetylcholinesterase activity, make covalent adducts on multiple proteins and promote protein crosslinking into high molecular weight aggregates - Lockridge_2023_Chem.Biol.Interact_14ChEPon_110460
Author(s) : Lockridge O , Schopfer LM
Ref : Chemico-Biological Interactions , :110460 , 2023
PubMedID: 36963650

Title : Organophosphorus Pesticides Promote Protein Cross-Linking - Schopfer_2022_Chem.Res.Toxicol__
Author(s) : Schopfer LM , Onder S , Lockridge O
Ref : Chemical Research in Toxicology , : , 2022
PubMedID: 36048166

Title : Butyrylcholinesterase in SH-SY5Y human neuroblastoma cells - Onder_2022_Neurotoxicol__
Author(s) : Onder S , Schopfer LM , Jiang W , Tacal O , Lockridge O
Ref : Neurotoxicology , : , 2022
PubMedID: 35189179

Title : Chlorpyrifos oxon crosslinking of amyloid beta 42 peptides is a new route for generation of self-aggregating amyloidogenic oligomers that promote Alzheimer's disease - Onder_2022_Chem.Biol.Interact_363_110029
Author(s) : Onder S , Biberoglu K , Tacal O , Schopfer LM
Ref : Chemico-Biological Interactions , 363 :110029 , 2022
PubMedID: 35779611

Title : Rabbit Antidiethoxyphosphotyrosine Antibody, Made by Single B Cell Cloning, Detects Chlorpyrifos Oxon-Modified Proteins in Cultured Cells and Immunopurifies Modified Peptides for Mass Spectrometry - Onder_2021_J.Proteome.Res__
Author(s) : Onder S , van Grol M , Fidder A , Xiao G , Noort D , Yerramalla U , Tacal O , Schopfer LM , Lockridge O
Ref : J Proteome Res , : , 2021
PubMedID: 34469172

Title : Evaluation of mass spectrometry MS\/MS spectra for the presence of isopeptide crosslinked peptides - Schopfer_2021_PLoS.One_16_e0254450
Author(s) : Schopfer LM , Onder S , Lockridge O
Ref : PLoS ONE , 16 :e0254450 , 2021
PubMedID: 34242352

Title : Characteristic fragment ions associated with dansyl cadaverine and biotin cadaverine adducts on glutamine - Biberoglu_2020_Anal.Biochem__113718
Author(s) : Biberoglu K , Schopfer LM , Tacal O , Lockridge O
Ref : Analytical Biochemistry , :113718 , 2020
PubMedID: 32335065

Title : Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers - Toker_2020_Chem.Biol.Interact__109007
Author(s) : Toker L , Silman I , Zeev-Ben-Mordehai T , Sussman JL , Schopfer LM , Lockridge O
Ref : Chemico-Biological Interactions , :109007 , 2020
PubMedID: 32087110

Title : Signature Ions in MS\/MS Spectra for Dansyl-Aminohexyl-QQIV Adducts on Lysine - Schopfer_2020_Molecules_25_
Author(s) : Schopfer LM , Lockridge O
Ref : Molecules , 25 : , 2020
PubMedID: 32521655

Title : Chlorpyrifos Oxon-Induced Isopeptide Bond Formation in Human Butyrylcholinesterase - Biberoglu_2020_Molecules_25_
Author(s) : Biberoglu K , Tacal O , Schopfer LM , Lockridge O
Ref : Molecules , 25 : , 2020
PubMedID: 31991818

Title : Mass Spectrometry Identifies Isopeptide Cross-Links Promoted by Diethylphosphorylated Lysine in Proteins Treated with Chlorpyrifos Oxon - Schopfer_2019_Chem.Res.Toxicol_32_762
Author(s) : Schopfer LM , Lockridge O
Ref : Chemical Research in Toxicology , 32 :762 , 2019
PubMedID: 30844252

Title : Purification of human butyrylcholinesterase from frozen Cohn fraction IV-4 by ion exchange and Hupresin affinity chromatography - Schopfer_2019_PLoS.One_14_e0209795
Author(s) : Schopfer LM , Lockridge O , David E , Hinrichs SH
Ref : PLoS ONE , 14 :e0209795 , 2019
PubMedID: 30625168

Title : Half-life of chlorpyrifos oxon and other organophosphorus esters in aqueous solution - Lockridge_2019_Chem.Biol.Interact__108788
Author(s) : Lockridge O , Verdier L , Schopfer LM
Ref : Chemico-Biological Interactions , :108788 , 2019
PubMedID: 31401088

Title : Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad - Grigorenko_2019_Chem.Biol.Interact_13ChEPon_306_138
Author(s) : Grigorenko BL , Novichkova DA , Lushchekina SV , Zueva IV , Schopfer LM , Nemukhin AV , Varfolomeev SD , Lockridge O , Masson P
Ref : Chemico-Biological Interactions , 306 :138 , 2019
PubMedID: 31009643

Title : Tetramer organizing polyproline-rich peptides identified by mass spectrometry after release of the peptides from Hupresin-purified butyrylcholinesterase tetramers isolated from milk of domestic pig (Sus scrofa) - Saxena_2018_Data.Brief_20_1607
Author(s) : Saxena A , Belinskaya T , Schopfer LM , Lockridge O
Ref : Data Brief , 20 :1607 , 2018
PubMedID: 30263913

Title : Purification of recombinant human butyrylcholinesterase on Hupresin(R) - Lockridge_2018_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1102-1103_109
Author(s) : Lockridge O , David E , Schopfer LM , Masson P , Brazzolotto X , Nachon F
Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 1102-1103 :109 , 2018
PubMedID: 30384187

Title : Optimization of Cholinesterase-Based Catalytic Bioscavengers Against Organophosphorus Agents - Lushchekina_2018_Front.Pharmacol_9_211
Author(s) : Lushchekina SV , Schopfer LM , Grigorenko BL , Nemukhin AV , Varfolomeev SD , Lockridge O , Masson P
Ref : Front Pharmacol , 9 :211 , 2018
PubMedID: 29593539

Title : Chlorpyrifos oxon promotes tubulin aggregation via isopeptide cross-linking between diethoxyphospho-Lys and Glu or Asp: Implications for neurotoxicity - Schopfer_2018_J.Biol.Chem_293_13566
Author(s) : Schopfer LM , Lockridge O
Ref : Journal of Biological Chemistry , 293 :13566 , 2018
PubMedID: 30006344

Title : Use of Hupresin To Capture Red Blood Cell Acetylcholinesterase for Detection of Soman Exposure - Onder_2018_Anal.Chem_90_974
Author(s) : Onder S , Schopfer LM , Cashman JR , Tacal O , Johnson RC , Blake TA , Lockridge O
Ref : Analytical Chemistry , 90 :974 , 2018
PubMedID: 29172437

Title : Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly - Leung_2018_Proc.Natl.Acad.Sci.U.S.A_115_13270
Author(s) : Leung MR , van Bezouwen LS , Schopfer LM , Sussman JL , Silman I , Lockridge O , Zeev-Ben-Mordehai T
Ref : Proc Natl Acad Sci U S A , 115 :13270 , 2018
PubMedID: 30538207
Gene_locus related to this paper: human-BCHE

Title : Characterization of butyrylcholinesterase from porcine milk - Saxena_2018_Arch.Biochem.Biophys_652_38
Author(s) : Saxena A , Belinskaya T , Schopfer LM , Lockridge O
Ref : Archives of Biochemistry & Biophysics , 652 :38 , 2018
PubMedID: 29908755
Gene_locus related to this paper: pig-BCHE

Title : Immunopurification of Acetylcholinesterase from Red Blood Cells for Detection of Nerve Agent Exposure - Dafferner_2017_Chem.Res.Toxicol_30_1897
Author(s) : Dafferner AJ , Schopfer LM , Xiao G , Cashman JR , Yerramalla U , Johnson RC , Blake TA , Lockridge O
Ref : Chemical Research in Toxicology , 30 :1897 , 2017
PubMedID: 28892361

Title : Hupresin Retains Binding Capacity for Butyrylcholinesterase and Acetylcholinesterase after Sanitation with Sodium Hydroxide - Onder_2017_Front.Pharmacol_8_713
Author(s) : Onder S , David E , Tacal O , Schopfer LM , Lockridge O
Ref : Front Pharmacol , 8 :713 , 2017
PubMedID: 29066970

Title : Monoclonal Antibody That Recognizes Diethoxyphosphotyrosine-Modified Proteins and Peptides Independent of Surrounding Amino Acids - Onder_2017_Chem.Res.Toxicol_30_2218
Author(s) : Onder S , Dafferner AJ , Schopfer LM , Xiao G , Yerramalla U , Tacal O , Blake TA , Johnson RC , Lockridge O
Ref : Chemical Research in Toxicology , 30 :2218 , 2017
PubMedID: 29137457

Title : The C5 Variant of the Butyrylcholinesterase Tetramer Includes a Noncovalently Bound 60 kDa Lamellipodin Fragment - Schopfer_2017_Molecules_22_
Author(s) : Schopfer LM , Delacour H , Masson P , Leroy J , Krejci E , Lockridge O
Ref : Molecules , 22 : , 2017
PubMedID: 28661448
Gene_locus related to this paper: human-BCHE

Title : Characterization of butyrylcholinesterase in bovine serum - Dafferner_2017_Chem.Biol.Interact_266_17
Author(s) : Dafferner AJ , Lushchekina SV , Masson P , Xiao G , Schopfer LM , Lockridge O
Ref : Chemico-Biological Interactions , 266 :17 , 2017
PubMedID: 28189703
Gene_locus related to this paper: bovin-BCHE

Title : Tetramer-organizing polyproline-rich peptides differ in CHO cell-expressed and plasma-derived human butyrylcholinesterase tetramers - Schopfer_2016_Biochim.Biophys.Acta_1864_706
Author(s) : Schopfer LM , Lockridge O
Ref : Biochimica & Biophysica Acta , 1864 :706 , 2016
PubMedID: 26947244

Title : Origin of polyproline-rich peptides in human butyrylcholinesterase tetramers - Peng_2016_Chem.Biol.Interact_259_63
Author(s) : Peng H , Schopfer LM , Lockridge O
Ref : Chemico-Biological Interactions , 259 :63 , 2016
PubMedID: 26876904

Title : Pure human butyrylcholinesterase hydrolyzes octanoyl ghrelin to desacyl ghrelin - Schopfer_2015_Gen.Comp.Endocrinol_224_61
Author(s) : Schopfer LM , Lockridge O , Brimijoin S
Ref : General & Comparative Endocrinology , 224 :61 , 2015
PubMedID: 26073531

Title : Detection of cresyl phosphate-modified butyrylcholinesterase in human plasma for chemical exposure associated with aerotoxic syndrome - Schopfer_2014_Anal.Biochem_461C_17
Author(s) : Schopfer LM , Masson P , Lamourette P , Simon S , Lockridge O
Ref : Analytical Biochemistry , 461C :17 , 2014
PubMedID: 24892986

Title : Characterization of a Novel BCHE Silent Allele: Point Mutation (p.Val204Asp) Causes Loss of Activity and Prolonged Apnea with Suxamethonium - Delacour_2014_PLoS.One_9_e101552
Author(s) : Delacour H , Lushchekina SV , Mabboux I , Bousquet A , Ceppa F , Schopfer LM , Lockridge O , Masson P
Ref : PLoS ONE , 9 :e101552 , 2014
PubMedID: 25054547

Title : Characterization of a novel butyrylcholinesterase point mutation (p.Ala34Val), silent with mivacurium - Delacour_2014_Biochem.Pharmacol_92_476
Author(s) : Delacour H , Lushchekina SV , Mabboux I , Ceppa F , Masson P , Schopfer LM , Lockridge O
Ref : Biochemical Pharmacology , 92 :476 , 2014
PubMedID: 25264279

Title : Healthy F-16 pilots show no evidence of exposure to tri-ortho-cresyl phosphate through the on-board oxygen generating system - Tacal_2014_Chem.Biol.Interact_215C_69
Author(s) : Tacal O , Schopfer LM
Ref : Chemico-Biological Interactions , 215C :69 , 2014
PubMedID: 24661946

Title : Matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry of titanium oxide-enriched peptides for detection of aged organophosphorus adducts on human butyrylcholinesterase - Jiang_2013_Anal.Biochem_439_132
Author(s) : Jiang W , Murashko EA , Dubrovskii YA , Podolskaya EP , Babakov VN , Mikler J , Nachon F , Masson P , Schopfer LM , Lockridge O
Ref : Analytical Biochemistry , 439 :132 , 2013
PubMedID: 23624322

Title : Polyproline tetramer organizing peptides in fetal bovine serum acetylcholinesterase - Biberoglu_2013_Biochim.Biophys.Acta_1834_745
Author(s) : Biberoglu K , Schopfer LM , Saxena A , Tacal O , Lockridge O
Ref : Biochimica & Biophysica Acta , 1834 :745 , 2013
PubMedID: 23352838

Title : PHOS-Select Iron Affinity Beads Enrich Peptides for the Detection of Organophosphorus Adducts on Albumin - Jiang_2013_Chem.Res.Toxicol_26_1917
Author(s) : Jiang W , Dubrovskii YA , Podolskaya EP , Murashko EA , Babakov VN , Nachon F , Masson P , Schopfer LM , Lockridge O
Ref : Chemical Research in Toxicology , 26 :1917 , 2013
PubMedID: 24187955

Title : Mass spectrometry method to identify aging pathways of Sp- and Rp-tabun adducts on human butyrylcholinesterase based on the acid labile P-N bond - Jiang_2013_Toxicol.Sci_132_390
Author(s) : Jiang W , Cashman JR , Nachon F , Masson P , Schopfer LM , Lockridge O
Ref : Toxicol Sci , 132 :390 , 2013
PubMedID: 23345579

Title : Resistance of human butyrylcholinesterase to methylene blue-catalyzed photoinactivation\; mass spectrometry analysis of oxidation products - Tacal_2013_Photochem.Photobiol_89_336
Author(s) : Tacal O , Li B , Lockridge O , Schopfer LM
Ref : Photochem Photobiol , 89 :336 , 2013
PubMedID: 23136924

Title : Cresyl saligenin phosphate makes multiple adducts on free histidine, but does not form an adduct on histidine 438 of human butyrylcholinesterase - Liyasova_2013_Chem.Biol.Interact_203_103
Author(s) : Liyasova MS , Schopfer LM , Lockridge O
Ref : Chemico-Biological Interactions , 203 :103 , 2013
PubMedID: 22898212

Title : Effects of viscosity and osmotic stress on the reaction of human butyrylcholinesterase with cresyl saligenin phosphate, a toxicant related to aerotoxic syndrome: kinetic and molecular dynamics studies - Masson_2013_Biochem.J_454_387
Author(s) : Masson P , Lushchekina SV , Schopfer LM , Lockridge O
Ref : Biochemical Journal , 454 :387 , 2013
PubMedID: 23782236

Title : Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry - Carletti_2013_Chem.Res.Toxicol_26_280
Author(s) : Carletti E , Colletier JP , Schopfer LM , Santoni G , Masson P , Lockridge O , Nachon F , Weik M
Ref : Chemical Research in Toxicology , 26 :280 , 2013
PubMedID: 23339663
Gene_locus related to this paper: human-BCHE , mouse-ACHE

Title : Newly observed spontaneous activation of ethephon as a butyrylcholinesterase inhibitor - Liyasova_2013_Chem.Res.Toxicol_26_422
Author(s) : Liyasova MS , Schopfer LM , Kodani S , Lantz SR , Casida JE , Lockridge O
Ref : Chemical Research in Toxicology , 26 :422 , 2013
PubMedID: 23410221

Title : Polyclonal antibody to soman-tyrosine - Li_2013_Chem.Res.Toxicol_26_584
Author(s) : Li B , Duysen EG , Froment MT , Masson P , Nachon F , Jiang W , Schopfer LM , Thiele GM , Klassen LW , Cashman JR , Williams GR , Lockridge O
Ref : Chemical Research in Toxicology , 26 :584 , 2013
PubMedID: 23469927

Title : The proline-rich tetramerization peptides in equine serum butyrylcholinesterase - Biberoglu_2012_Febs.J_279_3844
Author(s) : Biberoglu K , Schopfer LM , Tacal O , Lockridge O
Ref : Febs J , 279 :3844 , 2012
PubMedID: 22889087

Title : Analytical approaches for monitoring exposure to organophosphorus and carbamate agents through analysis of protein adducts - Schopfer_2012_Drug.Test.Anal_4_246
Author(s) : Schopfer LM , Lockridge O
Ref : Drug Test Anal , 4 :246 , 2012
PubMedID: 22359362

Title : Cresyl saligenin phosphate, an organophosphorus toxicant, makes covalent adducts with histidine, lysine, and tyrosine residues of human serum albumin - Liyasova_2012_Chem.Res.Toxicol_25_1752
Author(s) : Liyasova MS , Schopfer LM , Lockridge O
Ref : Chemical Research in Toxicology , 25 :1752 , 2012
PubMedID: 22793878

Title : Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran - Duysen_2012_Chem.Biol.Interact_195_189
Author(s) : Duysen EG , Cashman JR , Schopfer LM , Nachon F , Masson P , Lockridge O
Ref : Chemico-Biological Interactions , 195 :189 , 2012
PubMedID: 22209767

Title : Exposure to tri-o-cresyl phosphate detected in jet airplane passengers - Liyasova_2011_Toxicol.Appl.Pharmacol_256_337
Author(s) : Liyasova M , Li B , Schopfer LM , Nachon F , Masson P , Furlong CE , Lockridge O
Ref : Toxicol Appl Pharmacol , 256 :337 , 2011
PubMedID: 21723309

Title : X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger - Nachon_2011_Biochem.J_434_73
Author(s) : Nachon F , Carletti E , Wandhammer M , Nicolet Y , Schopfer LM , Masson P , Lockridge O
Ref : Biochemical Journal , 434 :73 , 2011
PubMedID: 21091433
Gene_locus related to this paper: human-BCHE

Title : Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis - Carletti_2011_Chem.Res.Toxicol_24_797
Author(s) : Carletti E , Schopfer LM , Colletier JP , Froment MT , Nachon F , Weik M , Lockridge O , Masson P
Ref : Chemical Research in Toxicology , 24 :797 , 2011
PubMedID: 21438623
Gene_locus related to this paper: human-BCHE

Title : Production of ES1 plasma carboxylesterase knockout mice for toxicity studies - Duysen_2011_Chem.Res.Toxicol_24_1891
Author(s) : Duysen EG , Koentgen F , Williams GR , Timperley CM , Schopfer LM , Cerasoli DM , Lockridge O
Ref : Chemical Research in Toxicology , 24 :1891 , 2011
PubMedID: 21875074
Gene_locus related to this paper: mouse-Ces1c

Title : Biomarkers of organophosphorus (OP) exposures in humans - Marsillach_2011_Neurotoxicol_32_656
Author(s) : Marsillach J , Richter RJ , Kim JH , Stevens RC , Maccoss MJ , Tomazela D , Suzuki SM , Schopfer LM , Lockridge O , Furlong CE
Ref : Neurotoxicology , 32 :656 , 2011
PubMedID: 21767566

Title : Dichlorvos, chlorpyrifos oxon and Aldicarb adducts of butyrylcholinesterase, detected by mass spectrometry in human plasma following deliberate overdose - Li_2010_J.Appl.Toxicol_30_559
Author(s) : Li B , Ricordel I , Schopfer LM , Baud F , Megarbane B , Masson P , Lockridge O
Ref : J Appl Toxicol , 30 :559 , 2010
PubMedID: 20809544

Title : Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos - Li_2010_Toxicol.Sci_116_23
Author(s) : Li B , Ricordel I , Schopfer LM , Baud F , Megarbane B , Nachon F , Masson P , Lockridge O
Ref : Toxicol Sci , 116 :23 , 2010
PubMedID: 20395308

Title : Development of diagnostics in the search for an explanation of aerotoxic syndrome - Schopfer_2010_Anal.Biochem_404_64
Author(s) : Schopfer LM , Furlong CE , Lockridge O
Ref : Analytical Biochemistry , 404 :64 , 2010
PubMedID: 20447373

Title : Reaction of human albumin with aspirin in vitro: mass spectrometric identification of acetylated lysines 199, 402, 519, and 545 - Liyasova_2010_Biochem.Pharmacol_79_784
Author(s) : Liyasova MS , Schopfer LM , Lockridge O
Ref : Biochemical Pharmacology , 79 :784 , 2010
PubMedID: 19836360

Title : Review of tyrosine and lysine as new motifs for organophosphate binding to proteins that have no active site serine - Lockridge_2010_Chem.Biol.Interact_187_344
Author(s) : Lockridge O , Schopfer LM
Ref : Chemico-Biological Interactions , 187 :344 , 2010
PubMedID: 20211158

Title : Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates - Schopfer_2010_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_878_1297
Author(s) : Schopfer LM , Grigoryan H , Li B , Nachon F , Masson P , Lockridge O
Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 878 :1297 , 2010
PubMedID: 19762289

Title : Mice treated with chlorpyrifos or chlorpyrifos oxon have organophosphorylated tubulin in the brain and disrupted microtubule structures, suggesting a role for tubulin in neurotoxicity associated with exposure to organophosphorus agents - Jiang_2010_Toxicol.Sci_115_183
Author(s) : Jiang W , Duysen EG , Hansen H , Shlyakhtenko L , Schopfer LM , Lockridge O
Ref : Toxicol Sci , 115 :183 , 2010
PubMedID: 20142434

Title : Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine - Grigoryan_2009_Chem.Biol.Interact_180_492
Author(s) : Grigoryan H , Li B , Anderson EK , Xue W , Nachon F , Lockridge O , Schopfer LM
Ref : Chemico-Biological Interactions , 180 :492 , 2009
PubMedID: 19539807

Title : Tyrosines of human and mouse transferrin covalently labeled by organophosphorus agents: a new motif for binding to proteins that have no active site serine - Li_2009_Toxicol.Sci_107_144
Author(s) : Li B , Schopfer LM , Grigoryan H , Thompson CM , Hinrichs SH , Masson P , Lockridge O
Ref : Toxicol Sci , 107 :144 , 2009
PubMedID: 18930948

Title : Carbofuran poisoning detected by mass spectrometry of butyrylcholinesterase adduct in human serum - Li_2009_J.Appl.Toxicol_29_149
Author(s) : Li H , Ricordel I , Tong L , Schopfer LM , Baud F , Megarbane B , Maury E , Masson P , Lockridge O
Ref : J Appl Toxicol , 29 :149 , 2009
PubMedID: 18937214

Title : Mass spectral characterization of organophosphate-labeled lysine in peptides. - Grigoryan_2009_Anal.Biochem_394_92
Author(s) : Grigoryan H , Li B , Xue W , Grigoryan M , Schopfer LM , Lockridge O
Ref : Analytical Biochemistry , 394 :92 , 2009
PubMedID: 19596251

Title : Mass spectrometry identifies multiple organophosphorylated sites on tubulin - Grigoryan_2009_Toxicol.Appl.Pharmacol_240_149
Author(s) : Grigoryan H , Schopfer LM , Peeples ES , Duysen EG , Grigoryan M , Thompson CM , Lockridge O
Ref : Toxicol Appl Pharmacol , 240 :149 , 2009
PubMedID: 19632257

Title : Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase - Gilley_2009_Chem.Res.Toxicol_22_1680
Author(s) : Gilley C , MacDonald M , Nachon F , Schopfer LM , Zhang J , Cashman JR , Lockridge O
Ref : Chemical Research in Toxicology , 22 :1680 , 2009
PubMedID: 19715348

Title : Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin - Ding_2008_Chem.Res.Toxicol_21_1787
Author(s) : Ding SJ , Carr J , Carlson JE , Tong L , Xue W , Li Y , Schopfer LM , Li B , Nachon F , Asojo OA , Thompson CM , Hinrichs SH , Masson P , Lockridge O
Ref : Chemical Research in Toxicology , 21 :1787 , 2008
PubMedID: 18707141

Title : Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents - Grigoryan_2008_Chem.Biol.Interact_175_180
Author(s) : Grigoryan H , Schopfer LM , Thompson CM , Terry AV , Masson P , Lockridge O
Ref : Chemico-Biological Interactions , 175 :180 , 2008
PubMedID: 18502412

Title : Kinetic analysis of effector modulation of butyrylcholinesterase-catalysed hydrolysis of acetanilides and homologous esters - Masson_2008_FEBS.J_275_2617
Author(s) : Masson P , Froment MT , Gillon E , Nachon F , Lockridge O , Schopfer LM
Ref : Febs J , 275 :2617 , 2008
PubMedID: 18422653

Title : Fast affinity purification coupled with mass spectrometry for identifying organophosphate labeled plasma butyrylcholinesterase - Li_2008_Chem.Biol.Interact_175_68
Author(s) : Li H , Tong L , Schopfer LM , Masson P , Lockridge O
Ref : Chemico-Biological Interactions , 175 :68 , 2008
PubMedID: 18586231

Title : Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramers - Li_2008_Biochem.J_411_425
Author(s) : Li H , Schopfer LM , Masson P , Lockridge O
Ref : Biochemical Journal , 411 :425 , 2008
PubMedID: 18076380

Title : Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population - Mikami_2008_Pharmacogenet.Genomics_18_213
Author(s) : Mikami LR , Wieseler S , de Souza RLR , Schopfer LM , Nachon F , Lockridge O , Chautard-Freire-Maia EA
Ref : Pharmacogenet Genomics , 18 :213 , 2008
PubMedID: 18300943

Title : A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters - Masson_2008_Chem.Biol.Interact_175_273
Author(s) : Masson P , Nachon F , Broomfield CA , Lenz DE , Verdier L , Schopfer LM , Lockridge O
Ref : Chemico-Biological Interactions , 175 :273 , 2008
PubMedID: 18508040

Title : Binding and hydrolysis of soman by human serum albumin - Li_2008_Chem.Res.Toxicol_21_421
Author(s) : Li B , Nachon F , Froment MT , Verdier L , Debouzy JC , Brasme B , Gillon E , Schopfer LM , Lockridge O , Masson P
Ref : Chemical Research in Toxicology , 21 :421 , 2008
PubMedID: 18163544

Title : Pseudo-esterase activity of human albumin: slow turnover on tyrosine 411 and stable acetylation of 82 residues including 59 lysines - Lockridge_2008_J.Biol.Chem_283_22582
Author(s) : Lockridge O , Xue W , Gaydess A , Grigoryan H , Ding SJ , Schopfer LM , Hinrichs SH , Masson P
Ref : Journal of Biological Chemistry , 283 :22582 , 2008
PubMedID: 18577514

Title : Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation - Carletti_2008_J.Am.Chem.Soc_130_16011
Author(s) : Carletti E , Li H , Li B , Ekstrom F , Nicolet Y , Loiodice M , Gillon E , Froment MT , Lockridge O , Schopfer LM , Masson P , Nachon F
Ref : Journal of the American Chemical Society , 130 :16011 , 2008
PubMedID: 18975951
Gene_locus related to this paper: human-BCHE , mouse-ACHE

Title : Expression of three naturally occurring genetic variants (G75R, E90D, I99M) of the BCHE gene of human butyrylcholinesterase - Mikami_2007_Pharmacogenet.Genomics_17_681
Author(s) : Mikami LR , Wieseler S , de Souza RLR , Schopfer LM , Lockridge O , Chautard-Freire-Maia EA
Ref : Pharmacogenet Genomics , 17 :681 , 2007
PubMedID: 17700357

Title : Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry - Li_2007_Toxicol.Sci_100_136
Author(s) : Li H , Schopfer LM , Nachon F , Froment MT , Masson P , Lockridge O
Ref : Toxicol Sci , 100 :136 , 2007
PubMedID: 17698511

Title : Matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411 - Li_2007_Anal.Biochem_361_263
Author(s) : Li B , Schopfer LM , Hinrichs SH , Masson P , Lockridge O
Ref : Analytical Biochemistry , 361 :263 , 2007
PubMedID: 17188226

Title : Aryl acylamidase activity of human serum albumin with o-nitrotrifluoroacetanilide as the substrate - Masson_2007_J.Enzyme.Inhib.Med.Chem_22_463
Author(s) : Masson P , Froment MT , Darvesh S , Schopfer LM , Lockridge O
Ref : J Enzyme Inhib Med Chem , 22 :463 , 2007
PubMedID: 17847714

Title : Kinetic analysis of butyrylcholinesterase-catalyzed hydrolysis of acetanilides - Masson_2007_Biochim.Biophys.Acta_1774_1139
Author(s) : Masson P , Froment MT , Gillon E , Nachon F , Darvesh S , Schopfer LM
Ref : Biochimica & Biophysica Acta , 1774 :1139 , 2007
PubMedID: 17690023

Title : Hydrolysis of oxo- and thio-esters by human butyrylcholinesterase - Masson_2007_Biochim.Biophys.Acta_1774_16
Author(s) : Masson P , Froment MT , Gillon E , Nachon F , Lockridge O , Schopfer LM
Ref : Biochimica & Biophysica Acta , 1774 :16 , 2007
PubMedID: 17182295

Title : Markers of organophosphate exposure in human serum - Wieseler_2006_J.Mol.Neurosci_30_93
Author(s) : Wieseler S , Schopfer LM , Lockridge O
Ref : Journal of Molecular Neuroscience , 30 :93 , 2006
PubMedID: 17192643

Title : Mutant of Bungarus fasciatus acetylcholinesterase with low affinity and low hydrolase activity toward organophosphorus esters - Poyot_2006_Biochim.Biophys.Acta_1764_1470
Author(s) : Poyot T , Nachon F , Froment MT , Loiodice M , Wieseler S , Schopfer LM , Lockridge O , Masson P
Ref : Biochimica & Biophysica Acta , 1764 :1470 , 2006
PubMedID: 16962835

Title : Characteristic mass spectral fragments of the organophosphorus agent FP-biotin and FP-biotinylated peptides from trypsin and bovine albumin (Tyr410) - Schopfer_2005_Anal.Biochem_345_122
Author(s) : Schopfer LM , Champion MM , Tamblyn N , Thompson CM , Lockridge O
Ref : Analytical Biochemistry , 345 :122 , 2005
PubMedID: 16125664

Title : Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase - Schopfer_2005_Chem.Res.Toxicol_18_747
Author(s) : Schopfer LM , Voelker T , Bartels CF , Thompson CM , Lockridge O
Ref : Chemical Research in Toxicology , 18 :747 , 2005
PubMedID: 15833035

Title : Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry - Peeples_2005_Toxicol.Sci_83_303
Author(s) : Peeples ES , Schopfer LM , Duysen EG , Spaulding R , Voelker T , Thompson CM , Lockridge O
Ref : Toxicol Sci , 83 :303 , 2005
PubMedID: 15525694

Title : Identification of organophosphate-reactive proteins by tandem mass spectrometry -
Author(s) : Li H , Schopfer LM , Spaulding R , Thompson CM , Lockridge O
Ref : Chemico-Biological Interactions , 157-158 :383 , 2005
PubMedID: 16429512

Title : Large scale purification of butyrylcholinesterase from human plasma suitable for injection into monkeys\; A potential new therapeutic for protection against cocaine end nerve agent toxicity - Lockridge_2005_J.Med.Chem.Biol.Radiol.Def_3_nihms5095
Author(s) : Lockridge O , Schopfer LM , Winger G , Woods JH
Ref : Journal of Medicinal Chemistryical Biology Radiol Def , 3 :nihms5095 , 2005
PubMedID: 16788731

Title : Hysteresis of butyrylcholinesterase in the approach to steady-state kinetics - Masson_2005_Chem.Biol.Interact_157-158_143
Author(s) : Masson P , Schopfer LM , Froment MT , Debouzy JC , Nachon F , Gillon E , Lockridge O , Hrabovska A , Goldstein BN
Ref : Chemico-Biological Interactions , 157-158 :143 , 2005
PubMedID: 16256969

Title : Life without acetylcholinesterase: the implications of cholinesterase inhibitor toxicity in AChE-knockout mice - Lockridge_2005_Environ.Toxicol.Pharmacol_19_463
Author(s) : Lockridge O , Duysen EG , Voelker T , Thompson CM , Schopfer LM
Ref : Environ Toxicol Pharmacol , 19 :463 , 2005
PubMedID: 21783513

Title : Hysteretic behavior of butyrylcholinesterase: Kinetic curiosity or catalytically and physiologicaly significant? -
Author(s) : Masson P , Froment MT , Nachon F , Lockridge O , Schopfer LM
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :191 , 2004
PubMedID:

Title : Poster (20) Hysteretic behavior of butyrylcholinesterase : kinetic curiosity or catalytically and physiologically significant? -
Author(s) : Masson P , Froment MT , Nachon F , Lockridge O , Schopfer LM
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :331 , 2004
PubMedID:

Title : Mutants of human butyrylcholinesterase with organophosphate hydrolase activity\; evidence that His117 is a general base catalyst for hydrolysis of echothiophate - Schopfer_2004_J.Med.Chem.Biol.Radiol.Def_2_1
Author(s) : Schopfer LM , Boeck AT , Broomfield CA , Lockridge O
Ref : Journal of Medicinal Chemistryical Biology Radiol Def , 2 :1 , 2004
PubMedID:

Title : Screening assays for cholinesterases resistant to inhibition by organophosphorus toxicants - Wang_2004_Anal.Biochem_329_131
Author(s) : Wang Y , Schopfer LM , Duysen EG , Nachon F , Masson P , Lockridge O
Ref : Analytical Biochemistry , 329 :131 , 2004
PubMedID: 15136175

Title : Hysteresis in butyrylcholinesterase catalysis. -
Author(s) : Masson P , Froment MT , Nachon F , Schopfer LM
Ref : Cholinergic Mechanisms, CRC Press :637 , 2004
PubMedID:

Title : Rate-determining step of butyrylcholinesterase-catalyzed hydrolysis of benzoylcholine and benzoylthiocholine. Volumetric study of wild-type and D70G mutant behavior - Masson_2004_Eur.J.Biochem_271_1980
Author(s) : Masson P , Bec N , Froment MT , Nachon F , Balny C , Lockridge O , Schopfer LM
Ref : European Journal of Biochemistry , 271 :1980 , 2004
PubMedID: 15128307

Title : Damped oscillatory hysteretic behaviour of butyrylcholinesterase with benzoylcholine as substrate - Masson_2004_Eur.J.Biochem_271_220
Author(s) : Masson P , Goldstein BN , Debouzy JC , Froment MT , Lockridge O , Schopfer LM
Ref : European Journal of Biochemistry , 271 :220 , 2004
PubMedID: 14686935

Title : DNA sequence of butyrylcholinesterase from the rat: expression of the protein and characterization of the properties of rat butyrylcholinesterase - Boeck_2002_Biochem.Pharmacol_63_2101
Author(s) : Boeck AT , Schopfer LM , Lockridge O
Ref : Biochemical Pharmacology , 63 :2101 , 2002
PubMedID: 12110369
Gene_locus related to this paper: ratno-BCHE

Title : Substrate activation in acetylcholinesterase induced by low pH or mutation in the pi-cation subsite - Masson_2002_Biochim.Biophys.Acta_1594_313
Author(s) : Masson P , Schopfer LM , Bartels CF , Froment MT , Ribes F , Nachon F , Lockridge O
Ref : Biochimica & Biophysica Acta , 1594 :313 , 2002
PubMedID: 11904227

Title : Butyrylcholinesterase-catalyzed hydrolysis of N-methylindoxyl acetate: analysis of volume changes upon reaction and hysteretic behavior - Masson_2002_Biochim.Biophys.Acta_1597_229
Author(s) : Masson P , Froment MT , Fort S , Ribes F , Bec N , Balny C , Schopfer LM
Ref : Biochimica & Biophysica Acta , 1597 :229 , 2002
PubMedID: 12044901

Title : Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to vx lethality - Duysen_2001_J.Pharmacol.Exp.Ther_299_528
Author(s) : Duysen EG , Li B , Xie W , Schopfer LM , Anderson RS , Broomfield CA , Lockridge O
Ref : Journal of Pharmacology & Experimental Therapeutics , 299 :528 , 2001
PubMedID: 11602663

Title : The active site of human paraoxonase (PON1) - Josse_2001_J.Appl.Toxicol_21 Suppl 1_S7
Author(s) : Josse D , Lockridge O , Xie W , Bartels CF , Schopfer LM , Masson P
Ref : J Appl Toxicol , 21 Suppl 1 :S7 , 2001
PubMedID: 11920913

Title : Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication. - Sun_2001_J.Biol.Chem_276_9330
Author(s) : Sun H , El Yazal J , Lockridge O , Schopfer LM , Brimijoin S , Pang YP
Ref : Journal of Biological Chemistry , 276 :9330 , 2001
PubMedID: 11104759

Title : Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma - Bartels_2000_Biochem.Pharmacol_60_479
Author(s) : Bartels CF , Xie W , Miller-Lindholm AK , Schopfer LM , Lockridge O
Ref : Biochemical Pharmacology , 60 :479 , 2000
PubMedID: 10874122
Gene_locus related to this paper: felca-ACHE , felca-BCHE , tiger-BCHE

Title : Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse - Li_2000_J.Neurochem_75_1320
Author(s) : Li B , Stribley JA , Ticu A , Xie W , Schopfer LM , Hammond P , Brimijoin S , Hinrichs SH , Lockridge O
Ref : Journal of Neurochemistry , 75 :1320 , 2000
PubMedID: 10936216

Title : Tryptophan residue(s) as major components of the human serum paraoxonase active site - Josse_1999_Chem.Biol.Interact_119-120_79
Author(s) : Josse D , Xie W , Masson P , Schopfer LM , Lockridge O
Ref : Chemico-Biological Interactions , 119-120 :79 , 1999
PubMedID: 10421441

Title : Identification of residues essential for human paraoxonase (PON1) arylesterase\/organophosphatase activities - Josse_1999_Biochemistry_38_2816
Author(s) : Josse D , Xie W , Renault F , Rochu D , Schopfer LM , Masson P , Lockridge O
Ref : Biochemistry , 38 :2816 , 1999
PubMedID: 10052953

Title : Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase - Masson_1997_Biochemistry_36_2266
Author(s) : Masson P , Legrand P , Bartels CF , Froment MT , Schopfer LM , Lockridge O
Ref : Biochemistry , 36 :2266 , 1997
PubMedID: 9047329

Title : Kinetics of heat inactivation of phenyl valerate hydrolases from hen and rat brain - Reiner_1987_Biochem.Pharmacol_36_3181
Author(s) : Reiner E , Davis CS , Schwab BW , Schopfer LM , Richardson RJ
Ref : Biochemical Pharmacology , 36 :3181 , 1987
PubMedID: 3663234