Gene Locus : human-BCHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Phosphotriesterase activity Slow aging dealkylation Millard_1998_Biochemistry_37_237 || Substrate activation strongly reduced substrate activation Masson_2001_Biochim.Biophys.Acta_1544_166 || Aging E197Q increases half-life of aging by DFP 60 times Masson_1997_Biochem.J_327_601
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Search for phosphotriesterase activity || Substrate activation || Aging
Torpedo_number : 199
Kinetic Parameter : No kinetic parameter
News : No news
Comment :
p.E197Q Glu197Gln (p.E225Q Glu225Gln in primary sequence with 28 amino-acids signal peptide) Slow aging dealkylation\; increases half-life of aging by DFP 60 times\; \;strongly reduced substrate activation
| Title : Effects of mutations of active site residues and amino acids interacting with the Omega loop on substrate activation of butyrylcholinesterase - Masson_2001_Biochim.Biophys.Acta_1544_166 |
| Author(s) : Masson P , Xie W , Froment MT , Lockridge O |
| Ref : Biochimica & Biophysica Acta , 1544 :166 , 2001 |
| Abstract : |
| PubMedSearch : Masson_2001_Biochim.Biophys.Acta_1544_166 |
| PubMedID: 11341926 |
| Gene_locus related to this paper: human-BCHE |
| Title : Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: design, construction and characterization - Broomfield_1999_Chem.Biol.Interact_119-120_413 |
| Author(s) : Broomfield CA , Lockridge O , Millard CB |
| Ref : Chemico-Biological Interactions , 119-120 :413 , 1999 |
| Abstract : |
| PubMedSearch : Broomfield_1999_Chem.Biol.Interact_119-120_413 |
| PubMedID: 10421478 |
| Title : Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanase - Millard_1998_Biochemistry_37_237 |
| Author(s) : Millard CB , Lockridge O , Broomfield CA |
| Ref : Biochemistry , 37 :237 , 1998 |
| Abstract : |
| PubMedSearch : Millard_1998_Biochemistry_37_237 |
| PubMedID: 9425044 |
| Gene_locus related to this paper: human-BCHE |
| Title : Aging of di-isopropyl-phosphorylated human butyrylcholinesterase - Masson_1997_Biochem.J_327_601 |
| Author(s) : Masson P , Fortier PL , Albaret C , Froment MT , Bartels CF , Lockridge O |
| Ref : Biochemical Journal , 327 ( Pt 2) :601 , 1997 |
| Abstract : |
| PubMedSearch : Masson_1997_Biochem.J_327_601 |
| PubMedID: 9359435 |