G117C_human-BCHE

General

Gene Locus : human-BCHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : Search for phosphotriesterase activity Phosphotriesterase activity OP sensitive Schopfer_2004_J.Med.Chem.Biol.Radiol.Def_2_1

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : Search for phosphotriesterase activity

Torpedo_number : 119

Kinetic Parameter : No kinetic parameter

News : No news

Comment :
p.G117C Gly117Cys (p.G145C Gly145Cys in primary sequence with 28 amino-acids signal peptide) Changing to acidic residues G117E and G117D were significantly reactive, but less nucleophilic residues such as G117S, G117C, and G117Y were not.

References (1)

Title : Mutants of human butyrylcholinesterase with organophosphate hydrolase activity\; evidence that His117 is a general base catalyst for hydrolysis of echothiophate - Schopfer_2004_J.Med.Chem.Biol.Radiol.Def_2_1
Author(s) : Schopfer LM , Boeck AT , Broomfield CA , Lockridge O
Ref : Journal of Medicinal Chemistryical Biology Radiol Def , 2 :1 , 2004
PubMedID: