Gene Locus : drome-ACHE
Mode of mutation : Site directed mutagenesis || Natural mutant
Disease :
Summary : Insecticide sensitivity Boublik_2002_Protein.Eng_15_43 || OP-resistance Found associated other mutations in Saltillo Bygdea and Pierrefeu strains, high resistance only in combination Mutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_592 || Binding of Triton X-100 studies no effect on Triton X-100 binding Marcel_2000_J.Biol.Chem_275_11603
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Insecticide sensitivity || OP-resistance || Binding of Triton X-100 studies
Torpedo_number : 227
Kinetic Parameter : No kinetic parameter
News : No news
Comment :
Mutation G265A in mature protein. Numbering in Boublik et al. 2002 || Chen et al. mutated the homologous aa in Lucilia cuprina AChE || p.Gly303Ala
| Title : A butterfly effect: highly insecticidal resistance caused by only a conservative residue mutated of drosophila melanogaster acetylcholinesterase - Fan_2009_J.Mol.Model_15_1229 |
| Author(s) : Fan F , You Z , Li Z , Cheng J , Tang Y , Tang Z |
| Ref : J Mol Model , 15 :1229 , 2009 |
| Abstract : |
| PubMedSearch : Fan_2009_J.Mol.Model_15_1229 |
| PubMedID: 19263097 |
| Title : Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster populations - Menozzi_2004_BMC.Evol.Biol_4_4 |
| Author(s) : Menozzi P , Shi MA , Lougarre A , Tang ZH , Fournier D |
| Ref : BMC Evol Biol , 4 :4 , 2004 |
| Abstract : |
| PubMedSearch : Menozzi_2004_BMC.Evol.Biol_4_4 |
| PubMedID: 15018651 |
| Title : Acetylcholinesterase alterations reveal the fitness cost of mutations conferring insecticide resistance - Shi_2004_BMC.Evol.Biol_4_5 |
| Author(s) : Shi MA , Lougarre A , Alies C , Fremaux I , Tang ZH , Stojan J , Fournier D |
| Ref : BMC Evol Biol , 4 :5 , 2004 |
| Abstract : |
| PubMedSearch : Shi_2004_BMC.Evol.Biol_4_5 |
| PubMedID: 15018650 |
| Title : Acetylcholinesterase engineering for detection of insecticide residues - Boublik_2002_Protein.Eng_15_43 |
| Author(s) : Boublik Y , Saint-Aguet P , Lougarre A , Arnaud M , Villatte F , Estrada-Mondaca S , Fournier D |
| Ref : Protein Engineering , 15 :43 , 2002 |
| Abstract : |
| PubMedSearch : Boublik_2002_Protein.Eng_15_43 |
| PubMedID: 11842237 |
| Title : The acetylcholinesterase gene and organophosphorus resistance in the Australian sheep blowfly, Lucilia cuprina - Chen_2001_Insect.Biochem.Mol.Biol_31_805 |
| Author(s) : Chen Z , Newcomb RD , Forbes E , McKenzie J , Batterham P |
| Ref : Insect Biochemistry & Molecular Biology , 31 :805 , 2001 |
| Abstract : |
| PubMedSearch : Chen_2001_Insect.Biochem.Mol.Biol_31_805 |
| PubMedID: 11378416 |
| Gene_locus related to this paper: luccu-ACHE |
| Title : Exploration of the Drosophila acetylcholinesterase substrate activation site using a reversible inhibitor (Triton X-100) and mutated enzymes - Marcel_2000_J.Biol.Chem_275_11603 |
| Author(s) : Marcel V , Estrada-Mondaca S , Magne F , Stojan J , Klaebe A , Fournier D |
| Ref : Journal of Biological Chemistry , 275 :11603 , 2000 |
| Abstract : |
| PubMedSearch : Marcel_2000_J.Biol.Chem_275_11603 |
| PubMedID: 10766776 |
| Title : Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase - Mutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922 |
| Author(s) : Mutero A , Pralavorio M , Bride JM , Fournier D |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 91 :5922 , 1994 |
| Abstract : |
| PubMedSearch : Mutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922 |
| PubMedID: 8016090 |