I199V_drome-ACHE

General

Gene Locus : drome-ACHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : Insecticide sensitivity Boublik_2002_Protein.Eng_15_43 || Insecticide sensitivity Menozzi_2004_BMC.Evol.Biol_4_4 || Insecticide sensitivity Chen_2001_Insect.Biochem.Mol.Biol_31_805 || OP-resistance OP-resistance lower than multiple mutations,mut found in Saltillo strain together with F115S G303A F368Y Mutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : Insecticide sensitivity || OP-resistance

Torpedo_number : 129

Kinetic Parameter : No kinetic parameter

News : No news

Comment :
Mutation I161V in mature protein. Numbering in Boublik et al. 2002 || Chen et al. mutated the homologous aa in Lucilia cuprina AChE || p.Ile199Val

References (5)

Title : Mutations of acetylcholinesterase which confer insecticide resistance in Drosophila melanogaster populations - Menozzi_2004_BMC.Evol.Biol_4_4
Author(s) : Menozzi P , Shi MA , Lougarre A , Tang ZH , Fournier D
Ref : BMC Evol Biol , 4 :4 , 2004
Abstract :
PubMedSearch : Menozzi_2004_BMC.Evol.Biol_4_4
PubMedID: 15018651

Title : Acetylcholinesterase alterations reveal the fitness cost of mutations conferring insecticide resistance - Shi_2004_BMC.Evol.Biol_4_5
Author(s) : Shi MA , Lougarre A , Alies C , Fremaux I , Tang ZH , Stojan J , Fournier D
Ref : BMC Evol Biol , 4 :5 , 2004
Abstract :
PubMedSearch : Shi_2004_BMC.Evol.Biol_4_5
PubMedID: 15018650

Title : Acetylcholinesterase engineering for detection of insecticide residues - Boublik_2002_Protein.Eng_15_43
Author(s) : Boublik Y , Saint-Aguet P , Lougarre A , Arnaud M , Villatte F , Estrada-Mondaca S , Fournier D
Ref : Protein Engineering , 15 :43 , 2002
Abstract :
PubMedSearch : Boublik_2002_Protein.Eng_15_43
PubMedID: 11842237

Title : The acetylcholinesterase gene and organophosphorus resistance in the Australian sheep blowfly, Lucilia cuprina - Chen_2001_Insect.Biochem.Mol.Biol_31_805
Author(s) : Chen Z , Newcomb RD , Forbes E , McKenzie J , Batterham P
Ref : Insect Biochemistry & Molecular Biology , 31 :805 , 2001
Abstract :
PubMedSearch : Chen_2001_Insect.Biochem.Mol.Biol_31_805
PubMedID: 11378416
Gene_locus related to this paper: luccu-ACHE

Title : Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase - Mutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922
Author(s) : Mutero A , Pralavorio M , Bride JM , Fournier D
Ref : Proceedings of the National Academy of Sciences of the United States of America , 91 :5922 , 1994
Abstract :
PubMedSearch : Mutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922
PubMedID: 8016090