Gene Locus : human-BCHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Peripheral Anionic Site vKi BW284C51 Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 || Peripheral Anionic Site no role in substrate binding Masson_1995_5th.ChE.Meeting.Madras__230
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Peripheral Anionic Site
Torpedo_number : 121
Kinetic Parameter : Butyrylthiocholine_Q119Y_human-BCHE, Tacrine_Q119Y_human-BCHE, Succinylcholine~Suxamethonium_Q119Y_human-BCHE, Dibucaine_Q119Y_human-BCHE, Solanine_Q119Y_human-BCHE, BW284C51_Q119Y_human-BCHE
News : No news
Comment :
p.Q119Y Gln119Tyr (p.Q147Y Gln147Tyr in primary sequence with 28 amino-acids signal peptide) Peripheral Anionic Site, no role in substrate binding
| Title : Asp7O in the peripheral anionic site of human butyrylcholinesterase - Masson_1996_Eur.J.Biochem_235_36 |
| Author(s) : Masson P , Froment MT , Bartels CF , Lockridge O |
| Ref : European Journal of Biochemistry , 235 :36 , 1996 |
| Abstract : |
| PubMedSearch : Masson_1996_Eur.J.Biochem_235_36 |
| PubMedID: 8631355 |
| Title : Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis - Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
| Author(s) : Loewenstein-Lichtenstein Y , Glick D , Gluzman N , Sternfeld M , Zakut H , Soreq H |
| Ref : Molecular Pharmacology , 50 :1423 , 1996 |
| Abstract : |
| PubMedSearch : Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423 |
| PubMedID: 8967962 |
| Gene_locus related to this paper: human-BCHE |
| Title : Peripheral Anionic Site of Wild-Type and Mutant Human Butyrylcholinesterase - |
| Author(s) : Masson P , Froment MT , Bartels CF , Lockridge O |
| Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :230 , 1995 |
| PubMedID: |