Gene Locus : torma-ACHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Peripheral Anionic Site strongly reduced inhibition by PAS ligand but inhib active site unaffected Harel_1992_Proc.Natl.Acad.Sci.U.S.A_89_10827 || Peripheral Anionic Site Increased thermal inactivation Increased reactivity of C231 Morel_1999_Mol.Pharmacol_55_982
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Peripheral Anionic Site
Torpedo_number : 279
Kinetic Parameter : No kinetic parameter
News : No news
Comment :
p.Trp279Ala
| Title : Effect of mutations within the peripheral anionic site on the stability of acetylcholinesterase - Morel_1999_Mol.Pharmacol_55_982 |
| Author(s) : Morel N , Bon S , Greenblatt HM , Van Belle D , Wodak SJ , Sussman JL , Massoulie J , Silman I |
| Ref : Molecular Pharmacology , 55 :982 , 1999 |
| Abstract : |
| PubMedSearch : Morel_1999_Mol.Pharmacol_55_982 |
| PubMedID: 10347238 |
| Title : Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis - Harel_1992_Proc.Natl.Acad.Sci.U.S.A_89_10827 |
| Author(s) : Harel M , Sussman JL , Krejci E , Bon S , Chanal P , Massoulie J , Silman I |
| Ref : Proceedings of the National Academy of Sciences of the United States of America , 89 :10827 , 1992 |
| Abstract : |
| PubMedSearch : Harel_1992_Proc.Natl.Acad.Sci.U.S.A_89_10827 |
| PubMedID: 1438284 |