W279A_torma-ACHE

General

Gene Locus : torma-ACHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : Peripheral Anionic Site strongly reduced inhibition by PAS ligand but inhib active site unaffected Harel_1992_Proc.Natl.Acad.Sci.U.S.A_89_10827 || Peripheral Anionic Site Increased thermal inactivation Increased reactivity of C231 Morel_1999_Mol.Pharmacol_55_982

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : Peripheral Anionic Site

Torpedo_number : 279

Kinetic Parameter : No kinetic parameter

News : No news

Comment :
p.Trp279Ala

References (2)

Title : Effect of mutations within the peripheral anionic site on the stability of acetylcholinesterase - Morel_1999_Mol.Pharmacol_55_982
Author(s) : Morel N , Bon S , Greenblatt HM , Van Belle D , Wodak SJ , Sussman JL , Massoulie J , Silman I
Ref : Molecular Pharmacology , 55 :982 , 1999
Abstract :
PubMedSearch : Morel_1999_Mol.Pharmacol_55_982
PubMedID: 10347238

Title : Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis - Harel_1992_Proc.Natl.Acad.Sci.U.S.A_89_10827
Author(s) : Harel M , Sussman JL , Krejci E , Bon S , Chanal P , Massoulie J , Silman I
Ref : Proceedings of the National Academy of Sciences of the United States of America , 89 :10827 , 1992
Abstract :
PubMedSearch : Harel_1992_Proc.Natl.Acad.Sci.U.S.A_89_10827
PubMedID: 1438284