torma-ACHE

Torpedo marmorata (Marbled electric ray) acetylcholinesterase

Comment

Alternate Cterminus: T or H peptide

Relationship

Family : ACHE

Block : C

Position in NCBI Life Tree : Torpedo marmorata

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Chondrichthyes N E > Elasmobranchii N E > Batoidea N E > Torpediniformes N E > Torpedinidae N E > Torpedo N E > Torpedo marmorata N E

Molecular evidence

C231A_torma-ACHE C231S\/L282A_torma-ACHE C231S\/N280Q\/L282S_torma-ACHE C231S_torma-ACHE C537D_torma-ACHE C537G_torma-ACHE C537S_torma-ACHE C537T\/D538T\/G539T_torca-ACHE D326N\/E327Q_torma-ACHE D326N_torma-ACHE D397N_torma-ACHE D93N_torma-ACHE D93V_torma-ACHE E327D_torma-ACHE E327Q_torma-ACHE E92L_torma-ACHE E92Q_torma-ACHE F288L\/F290V_torma-ACHE G80C\/C231S\/V431C_torma-ACHE G80C\/C231S_torma-ACHE G80C\/V431C\/_torma-ACHE G80C_torma-ACHE L282A_torma-ACHE L282S_torma-ACHE N280Q\/L282S_torma-ACHE N280Q_torma-ACHE R44E_torma-ACHE R44K_torma-ACHE S291G_torma-ACHE V129K\/C231S_torma-ACHE V129K_torma-ACHE V129R\/C231S_torma-ACHE V129R_torma-ACHE V431C\/C231S_torma-ACHE V431C_torma-ACHE W279A_torma-ACHE

No structure

Acetylthiocholine_WT_torma-ACHE BW284C51_WT_torma-ACHE D-tubocurarine_WT_torma-ACHE Decamethonium_WT_torma-ACHE Edrophonium_WT_torma-ACHE Gallamine~Flaxedil_WT_torma-ACHE Hexamethonium_WT_torma-ACHE Propidium_WT_torma-ACHE WT-fasciculin2_WT_torma-ACHE

No disease

Acetylcholine Acetylthiocholine

No inhibitor

Database

X05497 TMACHE

P07692

Sequence

Peptide

DDDSELLVNT KSGKVMRTRI PVLSSHISAF LGIPFAEPPV GNMRFRRPEP KKPWSGVWNA STYPNNCQQY VDEQFPGFPG SEMWNPNREM SEDCLYLNIW VPSPRPKSAT VMLWIYGGGF YSGSSTLDVY NGKYLAYTEE VVLVSLSYRV GAFGFLALHG SQEAPGNMGL LDQRMALQWV HDNIQFFGGD PKTVTLFGES AGRASVGMHI LSPGSRDLFR RAILQSGSPN CPWASVSVAE GRRRAVELRR NLNCNLNSDE DLIQCLREKK PQELIDVEWN VLPFDSIFRF SFVPVIDGEF FPTSLESMLN AGNFKKTQIL LGVNKDEGSF FLLYGAPGFS KDSESKISRE DFMSGVKLSV PHANDLGLDA VTLQYTDWMD DNNGIKNRDG LDDIVGDHNV ICPLMHFVNK YTKFGNGTYL YFFNHRASNL VWPEWMGVIH GYEIEFVFGL PLVKELNYTA EEEALSRRIM HYWATFAKTG NPNEPHSQES KWPLFTTKEQ KFIDLNTEPI KVHQRLRVQM CVFWNQFLPK LLNATETIDE AERQWKTEFH RWSSYMMHWK NQFDQYSRHE NCAEL

References (2)

Title : Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group - Bartolucci_2012_Biochem.J_444_269

Author(s) : Bartolucci C , Stojan J , Yu QS , Greig NH , Lamba D

Ref : Biochemical Journal , 444 :269 , 2012

Abstract :

PubMedSearch : Bartolucci_2012_Biochem.J_444_269

PubMedID: 22390827

Gene_locus related to this paper: torma-ACHE

Title : cDNA sequences of Torpedo marmorata acetylcholinesterase: primary structure of the precursor of a catalytic subunit\; existence of multiple 5'-untranslated regions - Sikorav_1987_EMBO.J_6_1865

Author(s) : Sikorav JL , Krejci E , Massoulie J

Ref : EMBO Journal , 6 :1865 , 1987

Abstract :

PubMedSearch : Sikorav_1987_EMBO.J_6_1865

PubMedID: 2820709

Gene_locus related to this paper: torma-ACHE

torma-ACHE

Comment

Relationship

Molecular evidence

Mutation (36)

Structure (0)

Kinetic (9)

Disease (0)

Substrate (2)

Inhibitor (0)

Database

Genbank (1)

Interpro (1)

Pfam (1)

UniProt (1)

PIRSF (1)

SUPERFAM (1)

Sequence

Peptide

References (2)

1. Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group - Bartolucci_2012_Biochem.J_444_269

2. cDNA sequences of Torpedo marmorata acetylcholinesterase: primary structure of the precursor of a catalytic subunit\; existence of multiple 5'-untranslated regions - Sikorav_1987_EMBO.J_6_1865