Y72A_human-ACHE

General

Gene Locus : human-ACHE

Mode of mutation : Site directed mutagenesis

Disease :

Summary : Omega loop No effect Velan_1996_FEBS.Lett_395_22 || Peripheral Anionic Site Increase inhibition by PAS ligands Barak_1994_J.Biol.Chem_269_6296

AAA Change :

Allelic Variant :

Risk Factor :

Inhibitor :

Structure :

Disease by interaction :

Interact Gene Locus :

Xenobiotic sensitivity :

Modification : Omega loop || Peripheral Anionic Site

Torpedo_number : 70

Kinetic Parameter : Acetylthiocholine_Y72A_human-ACHE, Edrophonium_Y72A_human-ACHE, Hexamethonium_Y72A_human-ACHE, BW284C51_Y72A_human-ACHE, Propidium_Y72A_human-ACHE, Decamethonium_Y72A_human-ACHE

News : No news

Comment :
p.Y72A Tyr72Ala (p.Y103A Tyr103Ala in primary sequence with 31 amino-acids signal peptide) Omega loop: No effect, Peripheral Anionic Site: Increase inhibition by PAS ligands

References (2)

Title : Structural modifications of the omega loop in human acetylcholinesterase - Velan_1996_FEBS.Lett_395_22
Author(s) : Velan B , Barak D , Ariel N , Leitner M , Bino T , Ordentlich A , Shafferman A
Ref : FEBS Letters , 395 :22 , 1996
PubMedID: 8849682

Title : Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core - Barak_1994_J.Biol.Chem_269_6296
Author(s) : Barak D , Kronman C , Ordentlich A , Ariel N , Bromberg A , Marcus D , Lazar A , Velan B , Shafferman A
Ref : Journal of Biological Chemistry , 269 :6296 , 1994
PubMedID: 8119978