Gene Locus : human-ACHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Omega loop No effect Velan_1996_FEBS.Lett_395_22 || Peripheral Anionic Site Increase inhibition by PAS ligands Barak_1994_J.Biol.Chem_269_6296
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Omega loop || Peripheral Anionic Site
Torpedo_number : 70
Kinetic Parameter : Acetylthiocholine_Y72A_human-ACHE, Edrophonium_Y72A_human-ACHE, Hexamethonium_Y72A_human-ACHE, BW284C51_Y72A_human-ACHE, Propidium_Y72A_human-ACHE, Decamethonium_Y72A_human-ACHE
News : No news
Comment :
p.Y72A Tyr72Ala (p.Y103A Tyr103Ala in primary sequence with 31 amino-acids signal peptide) Omega loop: No effect, Peripheral Anionic Site: Increase inhibition by PAS ligands
| Title : Structural modifications of the omega loop in human acetylcholinesterase - Velan_1996_FEBS.Lett_395_22 |
| Author(s) : Velan B , Barak D , Ariel N , Leitner M , Bino T , Ordentlich A , Shafferman A |
| Ref : FEBS Letters , 395 :22 , 1996 |
| Abstract : |
| PubMedSearch : Velan_1996_FEBS.Lett_395_22 |
| PubMedID: 8849682 |
| Title : Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core - Barak_1994_J.Biol.Chem_269_6296 |
| Author(s) : Barak D , Kronman C , Ordentlich A , Ariel N , Bromberg A , Marcus D , Lazar A , Velan B , Shafferman A |
| Ref : Journal of Biological Chemistry , 269 :6296 , 1994 |
| Abstract : |
| PubMedSearch : Barak_1994_J.Biol.Chem_269_6296 |
| PubMedID: 8119978 |