Gene Locus : human-CES1
Mode of mutation : Natural mutant
Disease :
Summary :
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity : CES-1 deficiency
Modification :
Torpedo_number : No torpedo number
Kinetic Parameter : No kinetic parameter
News : No news
Comment :
NG_012057.1:g.27467C>TorGorA chr16:55810697 CES1 Intron Variant. Genotypes GG + GT are associated with decreased risk of bleeding events when treated with Dabigatran in people with Atrial Fibrillation as compared to genotype TT. Association between CES1 rs2244613 and the pharmacokinetics and safety of dabigatran, Enalapril, Diltiazem, Simvastatin
| Title : Major implications of single nucleotide polymorphisms in human carboxylesterase 1 on substrate bioavailability - Yerrakula_2022_Biotechnol.Genet.Eng.Rev__ |
| Author(s) : Yerrakula G , Abraham S , John S , Zeharvi M , George SG , Senthil V , Maiz F , Rahman MH |
| Ref : Biotechnol Genet Eng Rev , :1 , 2022 |
| Abstract : |
| PubMedSearch : Yerrakula_2022_Biotechnol.Genet.Eng.Rev__ |
| PubMedID: 35946821 |
| Gene_locus related to this paper: human-CES1 |
| Title : Association between CES1 rs2244613 and the pharmacokinetics and safety of dabigatran: Meta-analysis and quantitative trait loci analysis - Li_2022_Front.Cardiovasc.Med_9_959916 |
| Author(s) : Li H , Zhang Z , Weng H , Qiu Y , Zubiaur P , Zhang Y , Fan G , Yang P , Vuorinen AL , Zuo X , Zhai Z , Wang C |
| Ref : Front Cardiovasc Med , 9 :959916 , 2022 |
| Abstract : |
| PubMedSearch : Li_2022_Front.Cardiovasc.Med_9_959916 |
| PubMedID: 35990949 |
| Title : The Influence of the CES1 Genotype on the Pharmacokinetics of Enalapril in Patients with Arterial Hypertension - Ikonnikova_2022_J.Pers.Med_12_580 |
| Author(s) : Ikonnikova A , Rodina T , Dmitriev A , Melnikov E , Kazakov R , Nasedkina T |
| Ref : J Pers Med , 12 : , 2022 |
| Abstract : |
| PubMedSearch : Ikonnikova_2022_J.Pers.Med_12_580 |
| PubMedID: 35455696 |
| Gene_locus related to this paper: human-CES1 |
| Title : Carboxylesterase 1 polymorphisms are associated with clinical outcomes in gastroenteric cancer patients treated with capecitabine - Liu_2021_Cancer.Chemother.Pharmacol__ |
| Author(s) : Liu D , Li X , Wang H , Dong M |
| Ref : Cancer Chemother Pharmacol , : , 2021 |
| Abstract : |
| PubMedSearch : Liu_2021_Cancer.Chemother.Pharmacol__ |
| PubMedID: 33586000 |
| Title : Variants of carboxylesterase 1 have no impact on capecitabine pharmacokinetics and toxicity in capecitabine plus oxaliplatin treated-colorectal cancer patients - Matsumoto_2020_Cancer.Chemother.Pharmacol__ |
| Author(s) : Matsumoto N , Kubota Y , Ishida H , Sekido M , Ohkuma R , Ishiguro T , Hirasawa Y , Ariizumi H , Tsunoda T , Ikusue T , Kobayashi K , Hisamatsu A , Toshima H , Shimada K , Fujita KI |
| Ref : Cancer Chemother Pharmacol , : , 2020 |
| Abstract : |
| PubMedSearch : Matsumoto_2020_Cancer.Chemother.Pharmacol__ |
| PubMedID: 32458030 |
| Title : Left atrial appendage thrombus formation in a patient with atrial fibrillation on dabigatran therapy associated with CES1 and ABCB1 genetic polymorphisms: A case report - Wu_2020_Medicine.(Baltimore)_99_e22084 |
| Author(s) : Wu T , Xia X , Fu J , Chen W , Zhang J |
| Ref : Medicine (Baltimore) , 99 :e22084 , 2020 |
| Abstract : |
| PubMedSearch : Wu_2020_Medicine.(Baltimore)_99_e22084 |
| PubMedID: 32899083 |
| Title : Effects of the rs2244613 polymorphism of the CES1 gene on the antiplatelet effect of the receptor P2Y12 blocker clopidogrel - Mirzaev_2019_Drug.Metab.Pers.Ther_34_ |
| Author(s) : Mirzaev KB , Osipova DV , Kitaeva EJ , Shprakh VV , Abdullaev SP , Andreev DA , Mumladze RB , Sychev DA |
| Ref : Drug Metab Pers Ther , 34 : , 2019 |
| Abstract : |
| PubMedSearch : Mirzaev_2019_Drug.Metab.Pers.Ther_34_ |
| PubMedID: 31560647 |
| Title : Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender - Shi_2016_Biochem.Pharmacol_119_76 |
| Author(s) : Shi J , Wang X , Nguyen JH , Bleske BE , Liang Y , Liu L , Zhu HJ |
| Ref : Biochemical Pharmacology , 119 :76 , 2016 |
| Abstract : |
| PubMedSearch : Shi_2016_Biochem.Pharmacol_119_76 |
| PubMedID: 27614009 |
| Gene_locus related to this paper: human-CES1 |
| Title : Association of Oseltamivir Activation with Gender and Carboxylesterase 1 Genetic Polymorphisms - Shi_2016_Basic.Clin.Pharmacol.Toxicol_119_555 |
| Author(s) : Shi J , Wang X , Eyler RF , Liang Y , Liu L , Mueller BA , Zhu HJ |
| Ref : Basic Clin Pharmacol Toxicol , 119 :555 , 2016 |
| Abstract : |
| PubMedSearch : Shi_2016_Basic.Clin.Pharmacol.Toxicol_119_555 |
| PubMedID: 27228223 |
| Gene_locus related to this paper: human-CES1 |
| Title : Pharmacodynamic Impact of Carboxylesterase 1 Gene Variants in Patients with Congestive Heart Failure Treated with Angiotensin-Converting Enzyme Inhibitors - Nelveg-Kristensen_2016_PLoS.One_11_e0163341 |
| Author(s) : Nelveg-Kristensen KE , Bie P , Ferrero L , Bjerre D , Bruun NE , Egfjord M , Rasmussen HB , Hansen PR |
| Ref : PLoS ONE , 11 :e0163341 , 2016 |
| Abstract : |
| PubMedSearch : Nelveg-Kristensen_2016_PLoS.One_11_e0163341 |
| PubMedID: 27662362 |