| Title : Neuroprotective and Antioxidant Activity of Arachidonoyl Choline, Its Bis-Quaternized Analogues and Other Acylcholines - Akimov_2020_Dokl.Biochem.Biophys_491_93 |
| Author(s) : Akimov MG , Dudina PV , Fomina-Ageeva EV , Gretskaya NM , Bosaya AA , Rudakova EV , Makhaeva GF , Kagarlitsky GO , Eremin SA , Tsetlin VI , Bezuglov VV |
| Ref : Dokl Biochem Biophys , 491 :93 , 2020 |
|
Abstract :
The antioxidant activity and protective effect in the toxicity model of H(2)O(2) were studied for arachidonic (AA-CHOL), docosahexaenoic (DHA-CHOL), linoleic (Ln-CHOL), and oleic (Ol-CHOL) fatty acids, as well as arachidonoyl dicholine (AA-diCHOL) and O-arachidonoyl bistetramethylaminoisopropanol (ABTAP). AA-CHOL, DHA-CHOL and Ln-CHOL provided a 20% increase in cell survival. AA-CHOL, AA-diCHOL, Ol-CHOL, and ABTAP had a radical-scavenging effect in the ABTS test, approximately equal to the activity of a standard radical scavenger Trolox. |
| PubMedSearch : Akimov_2020_Dokl.Biochem.Biophys_491_93 |
| PubMedID: 32483760 |
| Substrate | Arachidonoylcholine |
Akimov MG, Dudina PV, Fomina-Ageeva EV, Gretskaya NM, Bosaya AA, Rudakova EV, Makhaeva GF, Kagarlitsky GO, Eremin SA, Tsetlin VI, Bezuglov VV (2020)
Neuroprotective and Antioxidant Activity of Arachidonoyl Choline, Its Bis-Quaternized Analogues and Other Acylcholines
Dokl Biochem Biophys
491 :93
Akimov MG, Dudina PV, Fomina-Ageeva EV, Gretskaya NM, Bosaya AA, Rudakova EV, Makhaeva GF, Kagarlitsky GO, Eremin SA, Tsetlin VI, Bezuglov VV (2020)
Dokl Biochem Biophys
491 :93