Full name : Rudakova Elena V
First name : Elena V
Mail : Institute of Physiologically Active Compounds Russian Acad Sci\; Molecular Toxicology\; 1 Severny proezd\; Chernogolovka\; 142432
Zip Code :
City :
Country : Russia
Email : rudakova@ipac.ac.ru
Phone : +74965242597
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Comment
Title : 2-Arylhydrazinylidene-3-oxo-3-polyfluoroalkylpropanoic acids as selective and effective carboxylesterase inhibitors with powerful antioxidant potential - Burgart_2024_Bioorg.Med.Chem_115_117938 |
Author(s) : Burgart YV , Makhaeva GF , Khudina OG , Krasnykh OP , Kovaleva NV , Elkina NA , Boltneva NP , Rudakova EV , Lushchekina SV , Shchegolkov EV , Triandafilova GA , Malysheva KO , Serebryakova OG , Borisevich SS , Ilyina MG , Zhilina EF , Saloutin VI , Charushin VN , Richardson RJ |
Ref : Bioorganic & Medicinal Chemistry , 115 :117938 , 2024 |
Abstract : |
PubMedSearch : Burgart_2024_Bioorg.Med.Chem_115_117938 |
PubMedID: 39504592 |
Title : Combining Experimental and Computational Methods to Produce Conjugates of Anticholinesterase and Antioxidant Pharmacophores with Linker Chemistries Affecting Biological Activities Related to Treatment of Alzheimer's Disease - Makhaeva_2024_Molecules_29_321 |
Author(s) : Makhaeva GF , Kovaleva NV , Rudakova EV , Boltneva NP , Lushchekina SV , Astakhova TY , Timokhina EN , Serkov IV , Proshin AN , Soldatova YV , Poletaeva DA , Faingold, II , Mumyatova VA , Terentiev AA , Radchenko EV , Palyulin VA , Bachurin SO , Richardson RJ |
Ref : Molecules , 29 :321 , 2024 |
Abstract : |
PubMedSearch : Makhaeva_2024_Molecules_29_321 |
PubMedID: 38257233 |
Title : Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit beta-amyloid self-aggregation: potential therapeutic agents for Alzheimer's disease - Makhaeva_2023_Front.Pharmacol_14_1219980 |
Author(s) : Makhaeva GF , Kovaleva NV , Rudakova EV , Boltneva NP , Lushchekina SV , Astakhova TY , Timokhina EN , Serebryakova OG , Shchepochkin AV , Averkov MA , Utepova IA , Demina NS , Radchenko EV , Palyulin VA , Fisenko VP , Bachurin SO , Chupakhin ON , Charushin VN , Richardson RJ |
Ref : Front Pharmacol , 14 :1219980 , 2023 |
Abstract : |
PubMedSearch : Makhaeva_2023_Front.Pharmacol_14_1219980 |
PubMedID: 37654616 |
Title : Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer's Disease - Makhaeva_2023_Int.J.Mol.Sci_24_2285 |
Author(s) : Makhaeva GF , Kovaleva NV , Rudakova EV , Boltneva NP , Grishchenko MV , Lushchekina SV , Astakhova TY , Serebryakova OG , Timokhina EN , Zhilina EF , Shchegolkov EV , Ulitko MV , Radchenko EV , Palyulin VA , Burgart YV , Saloutin VI , Bachurin SO , Richardson RJ |
Ref : Int J Mol Sci , 24 :2285 , 2023 |
Abstract : |
PubMedSearch : Makhaeva_2023_Int.J.Mol.Sci_24_2285 |
PubMedID: 36768608 |
Title : Conjugates of amiridine and thiouracil derivatives as effective inhibitors of butyrylcholinesterase with the potential to block beta-amyloid aggregation - Khudina_2023_Arch.Pharm.(Weinheim)__e2300447 |
Author(s) : Khudina OG , Grishchenko MV , Makhaeva GF , Kovaleva NV , Boltneva NP , Rudakova EV , Lushchekina SV , Shchegolkov EV , Borisevich SS , Burgart YV , Saloutin VI , Charushin VN |
Ref : Arch Pharm (Weinheim) , :e2300447 , 2023 |
Abstract : |
PubMedSearch : Khudina_2023_Arch.Pharm.(Weinheim)__e2300447 |
PubMedID: 38072670 |
Title : Powerful Potential of Polyfluoroalkyl-Containing 4-Arylhydrazinylidenepyrazol-3-ones for Pharmaceuticals - Burgart_2022_Molecules_28_ |
Author(s) : Burgart YV , Elkina NA , Shchegolkov EV , Krasnykh OP , Makhaeva GF , Triandafilova GA , Solodnikov SY , Boltneva NP , Rudakova EV , Kovaleva NV , Serebryakova OG , Ulitko MV , Borisevich SS , Gerasimova NA , Evstigneeva NP , Kozlov SA , Korolkova YV , Minin AS , Belousova AV , Mozhaitsev ES , Klabukov AM , Saloutin VI |
Ref : Molecules , 28 : , 2022 |
Abstract : |
PubMedSearch : Burgart_2022_Molecules_28_ |
PubMedID: 36615256 |
Title : New Multifunctional Agents for Potential Alzheimer's Disease Treatment Based on Tacrine Conjugates with 2-Arylhydrazinylidene-1,3-Diketones - Elkina_2022_Biomolecules_12_ |
Author(s) : Elkina NA , Grishchenko MV , Shchegolkov EV , Makhaeva GF , Kovaleva NV , Rudakova EV , Boltneva NP , Lushchekina SV , Astakhova TY , Radchenko EV , Palyulin VA , Zhilina EF , Perminova AN , Lapshin LS , Burgart YV , Saloutin VI , Richardson RJ |
Ref : Biomolecules , 12 : , 2022 |
Abstract : |
PubMedSearch : Elkina_2022_Biomolecules_12_ |
PubMedID: 36358901 |
Title : Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease - Grishchenko_2022_ChemMedChem__e202200080 |
Author(s) : Grishchenko MV , Makhaeva GF , Burgart YV , Rudakova EV , Boltneva NP , Kovaleva NV , Serebryakova OG , Lushchekina SV , Astakhova TY , Zhilina EF , Shchegolkov EV , Richardson RJ , Saloutin VI |
Ref : ChemMedChem , :e202200080 , 2022 |
Abstract : |
PubMedSearch : Grishchenko_2022_ChemMedChem__e202200080 |
PubMedID: 35322571 |
Title : Conjugates of Methylene Blue with Cycloalkaneindoles as New Multifunctional Agents for Potential Treatment of Neurodegenerative Disease - Bachurin_2022_Int.J.Mol.Sci_23_ |
Author(s) : Bachurin SO , Shevtsova EF , Makhaeva GF , Aksinenko AY , Grigoriev VV , Goreva TV , Epishina TA , Kovaleva NV , Boltneva NP , Lushchekina SV , Rudakova EV , Vinogradova DV , Shevtsov PN , Pushkareva EA , Dubova LG , Serkova TP , Veselov IM , Fisenko VP , Richardson RJ |
Ref : Int J Mol Sci , 23 : , 2022 |
Abstract : |
PubMedSearch : Bachurin_2022_Int.J.Mol.Sci_23_ |
PubMedID: 36430413 |
Title : Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile - Makhaeva_2022_Molecules_27_ |
Author(s) : Makhaeva GF , Kovaleva NV , Boltneva NP , Rudakova EV , Lushchekina SV , Astakhova TY , Serkov IV , Proshin AN , Radchenko EV , Palyulin VA , Korabecny J , Soukup O , Bachurin SO , Richardson RJ |
Ref : Molecules , 27 : , 2022 |
Abstract : |
PubMedSearch : Makhaeva_2022_Molecules_27_ |
PubMedID: 35164325 |
Title : Amiridine-piperazine hybrids as cholinesterase inhibitors and potential multitarget agents for Alzheimer's disease treatment - Makhaeva_2021_Bioorg.Chem_112_104974 |
Author(s) : Makhaeva GF , Lushchekina SV , Kovaleva NV , Yu Astakhova T , Boltneva NP , Rudakova EV , Serebryakova OG , Proshin AN , Serkov IV , Trofimova TP , Tafeenko VA , Radchenko EV , Palyulin VA , Fisenko VP , Korabecny J , Soukup O , Richardson RJ |
Ref : Bioorg Chem , 112 :104974 , 2021 |
Abstract : |
PubMedSearch : Makhaeva_2021_Bioorg.Chem_112_104974 |
PubMedID: 34029971 |
Title : Novel potent bifunctional carboxylesterase inhibitors based on a polyfluoroalkyl-2-imino-1,3-dione scaffold - Makhaeva_2021_Eur.J.Med.Chem_218_113385 |
Author(s) : Makhaeva GF , Lushchekina SV , Boltneva NP , Serebryakova OG , Kovaleva NV , Rudakova EV , Elkina NA , Shchegolkov EV , Burgart YV , Stupina TS , Terentiev AA , Radchenko EV , Palyulin VA , Saloutin VI , Bachurin SO , Richardson RJ |
Ref : Eur Journal of Medicinal Chemistry , 218 :113385 , 2021 |
Abstract : |
PubMedSearch : Makhaeva_2021_Eur.J.Med.Chem_218_113385 |
PubMedID: 33831780 |
Title : Conjugation of Aminoadamantane and gamma-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands - Bachurin_2021_Molecules_26_ |
Author(s) : Bachurin SO , Makhaeva GF , Shevtsova EF , Aksinenko AY , Grigoriev VV , Shevtsov PN , Goreva TV , Epishina TA , Kovaleva NV , Pushkareva EA , Boltneva NP , Lushchekina SV , Gabrelyan AV , Zamoyski VL , Dubova LG , Rudakova EV , Fisenko VP , Bovina EV , Richardson RJ |
Ref : Molecules , 26 : , 2021 |
Abstract : |
PubMedSearch : Bachurin_2021_Molecules_26_ |
PubMedID: 34576998 |
Title : Neuroprotective and Antioxidant Activity of Arachidonoyl Choline, Its Bis-Quaternized Analogues and Other Acylcholines - Akimov_2020_Dokl.Biochem.Biophys_491_93 |
Author(s) : Akimov MG , Dudina PV , Fomina-Ageeva EV , Gretskaya NM , Bosaya AA , Rudakova EV , Makhaeva GF , Kagarlitsky GO , Eremin SA , Tsetlin VI , Bezuglov VV |
Ref : Dokl Biochem Biophys , 491 :93 , 2020 |
Abstract : |
PubMedSearch : Akimov_2020_Dokl.Biochem.Biophys_491_93 |
PubMedID: 32483760 |
Title : New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment - Makhaeva_2020_Molecules_25_3915 |
Author(s) : Makhaeva GF , Kovaleva NV , Boltneva NP , Lushchekina SV , Astakhova TY , Rudakova EV , Proshin AN , Serkov IV , Radchenko EV , Palyulin VA , Bachurin SO , Richardson RJ |
Ref : Molecules , 25 :3915 , 2020 |
Abstract : |
PubMedSearch : Makhaeva_2020_Molecules_25_3915 |
PubMedID: 32867324 |
Title : New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer's Disease Treatment - Makhaeva_2020_Molecules_25_5891 |
Author(s) : Makhaeva GF , Kovaleva NV , Rudakova EV , Boltneva NP , Lushchekina SV , Faingold, II , Poletaeva DA , Soldatova YV , Kotelnikova RA , Serkov IV , Ustinov AK , Proshin AN , Radchenko EV , Palyulin VA , Richardson RJ |
Ref : Molecules , 25 :5891 , 2020 |
Abstract : |
PubMedSearch : Makhaeva_2020_Molecules_25_5891 |
PubMedID: 33322783 |
Title : Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers - Khudina_2019_Bioorg.Med.Chem.Lett__126716 |
Author(s) : Khudina OG , Makhaeva GF , Elkina NA , Boltneva NP , Serebryakova OG , Shchegolkov EV , Rudakova EV , Lushchekina SV , Burgart YV , Bachurin SO , Richardson RJ , Saloutin VI |
Ref : Bioorganic & Medicinal Chemistry Lett , :126716 , 2019 |
Abstract : |
PubMedSearch : Khudina_2019_Bioorg.Med.Chem.Lett__126716 |
PubMedID: 31640885 |
Title : Cholinesterase and carboxylesterase inhibitors as pharmacological agents - Makhaeva_2019_Russ Chem Bull_68_967 |
Author(s) : Makhaeva GF , Rudakova EV , Kovaleva NV , Lushchekina SV , Boltneva NP , Proshin AN , Shchegolkov EV , Burgart YV , Saloutin VI |
Ref : Russ Chem Bull , 68 :967 , 2019 |
Abstract : |
PubMedSearch : Makhaeva_2019_Russ Chem Bull_68_967 |
PubMedID: |
Title : Anticholinesterase and Antioxidant Activity of New Binary Conjugates of gamma-Carbolines - Makhaeva_2019_Dokl.Biochem.Biophys_484_1 |
Author(s) : Makhaeva GF , Shevtsova EF , Boltneva NP , Kovaleva NV , Rudakova EV , Dubova LG , Shevtsov PN , Bachurin SO |
Ref : Dokl Biochem Biophys , 484 :1 , 2019 |
Abstract : |
PubMedSearch : Makhaeva_2019_Dokl.Biochem.Biophys_484_1 |
PubMedID: 31012000 |
Title : Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer's disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation - Makhaeva_2019_Bioorg.Chem__103387 |
Author(s) : Makhaeva GF , Kovaleva NV , Boltneva NP , Lushchekina SV , Rudakova EV , Stupina TS , Terentiev AA , Serkov IV , Proshin AN , Radchenko EV , Palyulin VV , Bachurin SO , Richardson RJ |
Ref : Bioorg Chem , :103387 , 2019 |
Abstract : |
PubMedSearch : Makhaeva_2019_Bioorg.Chem__103387 |
PubMedID: 31735356 |
Title : Conjugates of methylene blue with gamma-carboline derivatives as new multifunctional agents for the treatment of neurodegenerative diseases - Bachurin_2019_Sci.Rep_9_4873 |
Author(s) : Bachurin SO , Makhaeva GF , Shevtsova EF , Boltneva NP , Kovaleva NV , Lushchekina SV , Rudakova EV , Dubova LG , Vinogradova DV , Sokolov VB , Aksinenko AY , Fisenko VP , Richardson RJ , Aliev G |
Ref : Sci Rep , 9 :4873 , 2019 |
Abstract : |
PubMedSearch : Bachurin_2019_Sci.Rep_9_4873 |
PubMedID: 30890752 |
Title : Synthesis, molecular docking, and biological evaluation of 3-oxo-2-tolylhydrazinylidene-4,4,4-trifluorobutanoates bearing higher and natural alcohol moieties as new selective carboxylesterase inhibitors - Makhaeva_2019_Bioorg.Chem_91_103097 |
Author(s) : Makhaeva GF , Elkina NA , Shchegolkov EV , Boltneva NP , Lushchekina SV , Serebryakova OG , Rudakova EV , Kovaleva NV , Radchenko EV , Palyulin VA , Burgart YV , Saloutin VI , Bachurin SO , Richardson RJ |
Ref : Bioorg Chem , 91 :103097 , 2019 |
Abstract : |
PubMedSearch : Makhaeva_2019_Bioorg.Chem_91_103097 |
PubMedID: 31323527 |
Title : Overview of novel multifunctional agents based on conjugates of gamma-carbolines, carbazoles, tetrahydrocarbazoles, phenothiazines, and aminoadamantanes for treatment of Alzheimer's disease - Makhaeva_2019_Chem.Biol.Interact_13ChEPon_308_224 |
Author(s) : Makhaeva GF , Shevtsova EF , Boltneva NP , Lushchekina SV , Kovaleva NV , Rudakova EV , Bachurin SO , Richardson RJ |
Ref : Chemico-Biological Interactions , 308 :224 , 2019 |
Abstract : |
PubMedSearch : Makhaeva_2019_Chem.Biol.Interact_13ChEPon_308_224 |
PubMedID: 31100279 |
Title : Conjugates of Tacrine and Its Cyclic Homologues with p-Toluenesulfonamide as Novel Acetylcholinesterase and Butyrylcholinesterase Inhibitors - Makhaeva_2018_Dokl.Biochem.Biophys_483_369 |
Author(s) : Makhaeva GF , Kovaleva NV , Lushchekina SV , Rudakova EV , Boltneva NP , Proshin AN , Lednev BV , Serkov IV , Bachurin SO |
Ref : Dokl Biochem Biophys , 483 :369 , 2018 |
Abstract : |
PubMedSearch : Makhaeva_2018_Dokl.Biochem.Biophys_483_369 |
PubMedID: 30607741 |
Title : Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics - Makhaeva_2018_Bioorg.Med.Chem_26_4716 |
Author(s) : Makhaeva GF , Boltneva NP , Lushchekina SV , Rudakova EV , Serebryakova OG , Kulikova LN , Beloglazkin AA , Borisov RS , Richardson RJ |
Ref : Bioorganic & Medicinal Chemistry , 26 :4716 , 2018 |
Abstract : |
PubMedSearch : Makhaeva_2018_Bioorg.Med.Chem_26_4716 |
PubMedID: 30104121 |
Title : 9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment - Makhaeva_2017_Bioorg.Med.Chem_25_5981 |
Author(s) : Makhaeva GF , Lushchekina SV , Boltneva NP , Serebryakova OG , Rudakova EV , Ustyugov AA , Bachurin SO , Shchepochkin AV , Chupakhin ON , Charushin VN , Richardson RJ |
Ref : Bioorganic & Medicinal Chemistry , 25 :5981 , 2017 |
Abstract : |
PubMedSearch : Makhaeva_2017_Bioorg.Med.Chem_25_5981 |
PubMedID: 28986116 |
Title : Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors - Shchegol'kov_2017_Bioorg.Med.Chem_25_3997 |
Author(s) : Shchegol'kov EV , Makhaeva GF , Boltneva NP , Lushchekina SV , Serebryakova OG , Rudakova EV , Kovaleva NV , Burgart YV , Saloutin VI , Chupakhin ON , Bachurin SO , Richardson RJ |
Ref : Bioorganic & Medicinal Chemistry , 25 :3997 , 2017 |
Abstract : |
PubMedSearch : Shchegol'kov_2017_Bioorg.Med.Chem_25_3997 |
PubMedID: 28578994 |
Title : Novel conjugates of tacrine with 1,2,4,-thiadiazole as highly effective cholinesterase inhibitors, blockers of NMDA receptors, and antioxidants - Makhaeva_2017_Dokl.Biochem.Biophys_477_405 |
Author(s) : Makhaeva GF , Grigoriev VV , Proshin AN , Kovaleva NV , Rudakova EV , Boltneva NP , Serkov IV , Bachurin SO |
Ref : Dokl Biochem Biophys , 477 :405 , 2017 |
Abstract : |
PubMedSearch : Makhaeva_2017_Dokl.Biochem.Biophys_477_405 |
PubMedID: 29297118 |
Title : Neuropathy target esterase in mouse whole blood as a biomarker of exposure to neuropathic organophosphorus compounds - Makhaeva_2016_J.Appl.Toxicol_36_1468 |
Author(s) : Makhaeva GF , Rudakova EV , Sigolaeva LV , Kurochkin IN , Richardson RJ |
Ref : J Appl Toxicol , 36 :1468 , 2016 |
Abstract : |
PubMedSearch : Makhaeva_2016_J.Appl.Toxicol_36_1468 |
PubMedID: 26970094 |
Title : Esterase profiles of organophosphorus compounds in vitro predict their behavior in vivo - Makhaeva_2016_Chem.Biol.Interact_259_332 |
Author(s) : Makhaeva GF , Rudakova EV , Serebryakova OG , Aksinenko AY , Lushchekina SV , Bachurin SO , Richardson RJ |
Ref : Chemico-Biological Interactions , 259 :332 , 2016 |
Abstract : |
PubMedSearch : Makhaeva_2016_Chem.Biol.Interact_259_332 |
PubMedID: 27154493 |
Title : Further studies toward a mouse model for biochemical assessment of neuropathic potential of organophosphorus compounds - Makhaeva_2014_J.Appl.Toxicol_34_1426 |
Author(s) : Makhaeva GF , Rudakova EV , Hein ND , Serebryakova OG , Kovaleva NV , Boltneva NP , Fink JK , Richardson RJ |
Ref : J Appl Toxicol , 34 :1426 , 2014 |
Abstract : |
PubMedSearch : Makhaeva_2014_J.Appl.Toxicol_34_1426 |
PubMedID: 24395470 |
Title : Organophosphorus compound esterase profiles as predictors of therapeutic and toxic effects - Makhaeva_2013_Chem.Biol.Interact_203_231 |
Author(s) : Makhaeva GF , Radchenko EV , Palyulin VA , Rudakova EV , Aksinenko AY , Sokolov VB , Zefirov NS , Richardson RJ |
Ref : Chemico-Biological Interactions , 203 :231 , 2013 |
Abstract : |
PubMedSearch : Makhaeva_2013_Chem.Biol.Interact_203_231 |
PubMedID: 23123251 |
Title : A new selective inhibitor of mouse blood plasma carboxylesterase - |
Author(s) : Rudakova EV , Makhaeva GF , Galenko TG , Aksinenko AY , Sokolov VB , Martynov IV |
Ref : Dokl Biochem Biophys , 449 :87 , 2013 |
PubMedID: 23657654 |
Title : Esterase profile of O-phosphorylated ethyltrifluorolactates in prediction of their therapeutic and toxic effects - |
Author(s) : Rudakova EV , Makhaeva GF , Galenko TG , Aksinenko AY , Sokolov VB , Richardson RJ , Martynov IV |
Ref : Dokl Biochem Biophys , 443 :81 , 2012 |
PubMedID: 22562631 |
Title : Comparative analysis of esterase activities of human, mouse, and rat blood - Rudakova_2011_Bull.Exp.Biol.Med_152_73 |
Author(s) : Rudakova EV , Boltneva NP , Makhaeva GF |
Ref : Bulletin of Experimental Biology & Medicine , 152 :73 , 2011 |
Abstract : |
PubMedSearch : Rudakova_2011_Bull.Exp.Biol.Med_152_73 |
PubMedID: 22803044 |
Title : Biosensor analysis of blood esterases for organophosphorus compounds exposure assessment: approaches to simultaneous determination of several esterases - Sigolaeva_2010_Chem.Biol.Interact_187_312 |
Author(s) : Sigolaeva LV , Makhaeva GF , Rudakova EV , Boltneva NP , Porus M , Dubacheva G , Eremenko A , Kurochkin I , Richardson RJ |
Ref : Chemico-Biological Interactions , 187 :312 , 2010 |
Abstract : |
PubMedSearch : Sigolaeva_2010_Chem.Biol.Interact_187_312 |
PubMedID: 20097186 |