Beetham_1995_DNA.Cell.Biol_14_61

Reference

Title : Gene evolution of epoxide hydrolases and recommended nomenclature - Beetham_1995_DNA.Cell.Biol_14_61
Author(s) : Beetham JK , Grant D , Arand M , Garbarino J , Kiyosue T , Pinot F , Oesch F , Belknap WR , Shinozaki K , Hammock BD
Ref : DNA & Cell Biology , 14 :61 , 1995
Abstract :

We have analyzed amino acid sequence relationships among soluble and microsomal epoxide hydrolases, haloacid dehalogenases, and a haloalkane dehalogenase. The amino-terminal residues (1-229) of mammalian soluble epoxide hydrolase are homologous to a haloacid dehalogenase. The carboxy-terminal residues (230-554) of mammalian soluble epoxide hydrolase are homologous to haloalkane dehalogenase, to plant soluble epoxide hydrolase, and to microsomal epoxide hydrolase. The shared identity between the haloacid and haloalkane dehalogenases does not indicate relatedness between these two types of dehalogenases. The amino-terminal and carboxy-terminal homologies of mammalian soluble epoxide hydrolase to the respective dehalogenases suggests that this epoxide hydrolase, but not the soluble epoxide hydrolase of plant or the microsomal epoxide hydrolase, derives from a gene fusion. The homology of microsomal to soluble epoxide hydrolase suggests they derive from a gene duplication, probably of an ancestral bacterial (epoxide) hydrolase gene. Based on homology to haloalkane dehalogenase, the catalytic residues for the soluble and microsomal epoxide hydrolases are predicted. A nomenclature system based on divergent molecular evolution is proposed for these epoxide hydrolases.

PubMedSearch : Beetham_1995_DNA.Cell.Biol_14_61
PubMedID: 7832993
Gene_locus related to this paper: mouse-hyes

Related information

Gene_locus mouse-hyes
Family Epoxide_hydrolase
Structure 1CQZ

Citations formats

Beetham JK, Grant D, Arand M, Garbarino J, Kiyosue T, Pinot F, Oesch F, Belknap WR, Shinozaki K, Hammock BD (1995)
Gene evolution of epoxide hydrolases and recommended nomenclature
DNA & Cell Biology 14 :61

Beetham JK, Grant D, Arand M, Garbarino J, Kiyosue T, Pinot F, Oesch F, Belknap WR, Shinozaki K, Hammock BD (1995)
DNA & Cell Biology 14 :61