| Title : Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in alzheimer disease - Brindle_1998_Hum.Mol.Genet_7_933 |
| Author(s) : Brindle N , Song Y , Rogaeva E , Premkumar S , Levesque G , Yu G , Ikeda M , Nishimura M , Paterson A , Sorbi S , Duara R , Farrer L , St George-Hyslop P |
| Ref : Hum Mol Genet , 7 :933 , 1998 |
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Abstract :
The K-variant of butyrylcholinesterase (BCHE-K) recently has been reported to be associated with Alzheimer disease (AD) in carriers of the epsilon4 allele of the apolipoprotein E (APOE) gene. We have re-examined the frequency of the BCHE-K allele in a large data set of both sporadic and familial cases of AD disease, and we have also examined the segregation of three genetic markers on chromosome 3 near BCHE . Our data neither support an association of BCHE-K with sporadic or familial AD, nor do they suggest the existence of another gene nearby on chromosome 3 as a common cause of familial AD. |
| PubMedSearch : Brindle_1998_Hum.Mol.Genet_7_933 |
| PubMedID: 9536099 |
Brindle N, Song Y, Rogaeva E, Premkumar S, Levesque G, Yu G, Ikeda M, Nishimura M, Paterson A, Sorbi S, Duara R, Farrer L, St George-Hyslop P (1998)
Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in alzheimer disease
Hum Mol Genet
7 :933
Brindle N, Song Y, Rogaeva E, Premkumar S, Levesque G, Yu G, Ikeda M, Nishimura M, Paterson A, Sorbi S, Duara R, Farrer L, St George-Hyslop P (1998)
Hum Mol Genet
7 :933