Chain_2004_Proc.Natl.Acad.Sci.U.S.A_101_13826

Reference

Title : Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis - Chain_2004_Proc.Natl.Acad.Sci.U.S.A_101_13826
Author(s) : Chain PS , Carniel E , Larimer FW , Lamerdin J , Stoutland PO , Regala WM , Georgescu AM , Vergez LM , Land ML , Motin VL , Brubaker RR , Fowler J , Hinnebusch J , Marceau M , Medigue C , Simonet M , Chenal-Francisque V , Souza B , Dacheux D , Elliott JM , Derbise A , Hauser LJ , Garcia E
Ref : Proc Natl Acad Sci U S A , 101 :13826 , 2004
Abstract :

Yersinia pestis, the causative agent of plague, is a highly uniform clone that diverged recently from the enteric pathogen Yersinia pseudotuberculosis. Despite their close genetic relationship, they differ radically in their pathogenicity and transmission. Here, we report the complete genomic sequence of Y. pseudotuberculosis IP32953 and its use for detailed genome comparisons with available Y. pestis sequences. Analyses of identified differences across a panel of Yersinia isolates from around the world reveal 32 Y. pestis chromosomal genes that, together with the two Y. pestis-specific plasmids, to our knowledge, represent the only new genetic material in Y. pestis acquired since the the divergence from Y. pseudotuberculosis. In contrast, 149 other pseudogenes (doubling the previous estimate) and 317 genes absent from Y. pestis were detected, indicating that as many as 13% of Y. pseudotuberculosis genes no longer function in Y. pestis. Extensive insertion sequence-mediated genome rearrangements and reductive evolution through massive gene loss, resulting in elimination and modification of preexisting gene expression pathways, appear to be more important than acquisition of genes in the evolution of Y. pestis. These results provide a sobering example of how a highly virulent epidemic clone can suddenly emerge from a less virulent, closely related progenitor.

PubMedSearch : Chain_2004_Proc.Natl.Acad.Sci.U.S.A_101_13826
PubMedID: 15358858
Gene_locus related to this paper: yerpe-BIOH , yerpe-dlhh , yerpe-IRP1 , yerpe-PIP , yerpe-PLDB , yerpe-PTRB , yerpe-Y0507 , yerpe-Y0644 , yerpe-y1616 , yerpe-y3224 , yerpe-YBTT , yerpe-YPLA , yerpe-YPO0180 , yerpe-YPO0667 , yerpe-YPO0773 , yerpe-YPO0776 , yerpe-YPO0986 , yerpe-YPO1501 , yerpe-YPO1997 , yerpe-YPO2002 , yerpe-YPO2336 , yerpe-YPO2526 , yerpe-YPO2638 , yerpe-YPO2814

Related information

Gene_locus yerpe-BIOH    yerpe-dlhh    yerpe-IRP1    yerpe-PIP    yerpe-PLDB    yerpe-PTRB    yerpe-Y0507    yerpe-Y0644    yerpe-y1616    yerpe-y3224    yerpe-YBTT    yerpe-YPLA    yerpe-YPO0180    yerpe-YPO0667    yerpe-YPO0773    yerpe-YPO0776    yerpe-YPO0986    yerpe-YPO1501    yerpe-YPO1997    yerpe-YPO2002    yerpe-YPO2336    yerpe-YPO2526    yerpe-YPO2638    yerpe-YPO2814

Citations formats

Chain PS, Carniel E, Larimer FW, Lamerdin J, Stoutland PO, Regala WM, Georgescu AM, Vergez LM, Land ML, Motin VL, Brubaker RR, Fowler J, Hinnebusch J, Marceau M, Medigue C, Simonet M, Chenal-Francisque V, Souza B, Dacheux D, Elliott JM, Derbise A, Hauser LJ, Garcia E (2004)
Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis
Proc Natl Acad Sci U S A 101 :13826

Chain PS, Carniel E, Larimer FW, Lamerdin J, Stoutland PO, Regala WM, Georgescu AM, Vergez LM, Land ML, Motin VL, Brubaker RR, Fowler J, Hinnebusch J, Marceau M, Medigue C, Simonet M, Chenal-Francisque V, Souza B, Dacheux D, Elliott JM, Derbise A, Hauser LJ, Garcia E (2004)
Proc Natl Acad Sci U S A 101 :13826