Carniel E

References (5)

Title : Parallel independent evolution of pathogenicity within the genus Yersinia - Reuter_2014_Proc.Natl.Acad.Sci.U.S.A_111_6768
Author(s) : Reuter S , Connor TR , Barquist L , Walker D , Feltwell T , Harris SR , Fookes M , Hall ME , Petty NK , Fuchs TM , Corander J , Dufour M , Ringwood T , Savin C , Bouchier C , Martin L , Miettinen M , Shubin M , Riehm JM , Laukkanen-Ninios R , Sihvonen LM , Siitonen A , Skurnik M , Falcao JP , Fukushima H , Scholz HC , Prentice MB , Wren BW , Parkhill J , Carniel E , Achtman M , McNally A , Thomson NR
Ref : Proc Natl Acad Sci U S A , 111 :6768 , 2014
Abstract : The genus Yersinia has been used as a model system to study pathogen evolution. Using whole-genome sequencing of all Yersinia species, we delineate the gene complement of the whole genus and define patterns of virulence evolution. Multiple distinct ecological specializations appear to have split pathogenic strains from environmental, nonpathogenic lineages. This split demonstrates that contrary to hypotheses that all pathogenic Yersinia species share a recent common pathogenic ancestor, they have evolved independently but followed parallel evolutionary paths in acquiring the same virulence determinants as well as becoming progressively more limited metabolically. Shared virulence determinants are limited to the virulence plasmid pYV and the attachment invasion locus ail. These acquisitions, together with genomic variations in metabolic pathways, have resulted in the parallel emergence of related pathogens displaying an increasingly specialized lifestyle with a spectrum of virulence potential, an emerging theme in the evolution of other important human pathogens.
ESTHER : Reuter_2014_Proc.Natl.Acad.Sci.U.S.A_111_6768
PubMedSearch : Reuter_2014_Proc.Natl.Acad.Sci.U.S.A_111_6768
PubMedID: 24753568
Gene_locus related to this paper: yeren-k1bwy7

Title : Draft Genome Sequence of a Clinical Strain of Yersinia enterocolitica (IP10393) of Bioserotype 4\/O:3 from France - Savin_2013_Genome.Announc_1_e00150
Author(s) : Savin C , Frangeul L , Ma L , Bouchier C , Moszer I , Carniel E
Ref : Genome Announc , 1 :e00150 , 2013
Abstract : We sequenced the genome of a clinical isolate of Yersinia enterocolitica (IP10393) from France. This strain belongs to bioserotype 4/O:3, which is the most common pathogenic subgroup worldwide. The draft genome has a size of 4,463,212 bp and a G+C content of 47.0%, and it is predicted to contain 4,181 coding sequences.
ESTHER : Savin_2013_Genome.Announc_1_e00150
PubMedSearch : Savin_2013_Genome.Announc_1_e00150
PubMedID: 23469338
Gene_locus related to this paper: yerbe-c4rym7 , yeren-k1bwy7

Title : The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever - Eppinger_2007_PLoS.Genet_3_e142
Author(s) : Eppinger M , Rosovitz MJ , Fricke WF , Rasko DA , Kokorina G , Fayolle C , Lindler LE , Carniel E , Ravel J
Ref : PLoS Genet , 3 :e142 , 2007
Abstract : The first reported Far East scarlet-like fever (FESLF) epidemic swept the Pacific coastal region of Russia in the late 1950s. Symptoms of the severe infection included erythematous skin rash and desquamation, exanthema, hyperhemic tongue, and a toxic shock syndrome. The term FESLF was coined for the infection because it shares clinical presentations with scarlet fever caused by group A streptococci. The causative agent was later identified as Yersinia pseudotuberculosis, although the range of morbidities was vastly different from classical pseudotuberculosis symptoms. To understand the origin and emergence of the peculiar clinical features of FESLF, we have sequenced the genome of the FESLF-causing strain Y. pseudotuberculosis IP31758 and compared it with that of another Y. pseudotuberculosis strain, IP32953, which causes classical gastrointestinal symptoms. The unique gene pool of Y pseudotuberculosis IP31758 accounts for more than 260 strain-specific genes and introduces individual physiological capabilities and virulence determinants, with a significant proportion horizontally acquired that likely originated from Enterobacteriaceae and other soil-dwelling bacteria that persist in the same ecological niche. The mobile genome pool includes two novel plasmids phylogenetically unrelated to all currently reported Yersinia plasmids. An icm/dot type IVB secretion system, shared only with the intracellular persisting pathogens of the order Legionellales, was found on the larger plasmid and could contribute to scarlatinoid fever symptoms in patients due to the introduction of immunomodulatory and immunosuppressive capabilities. We determined the common and unique traits resulting from genome evolution and speciation within the genus Yersinia and drew a more accurate species border between Y. pseudotuberculosis and Y. pestis. In contrast to the lack of genetic diversity observed in the evolutionary young descending Y. pestis lineage, the population genetics of Y. pseudotuberculosis is more heterogenous. Both Y. pseudotuberculosis strains IP31758 and the previously sequenced Y. pseudotuberculosis strain IP32953 have evolved by the acquisition of specific plasmids and by the horizontal acquisition and incorporation of different genetic information into the chromosome, which all together or independently seems to potentially impact the phenotypic adaptation of these two strains.
ESTHER : Eppinger_2007_PLoS.Genet_3_e142
PubMedSearch : Eppinger_2007_PLoS.Genet_3_e142
PubMedID: 17784789
Gene_locus related to this paper: yerpe-BIOH , yerpe-dlhh , yerpe-PIP , yerpe-PTRB , yerpe-Y0507 , yerpe-y1616 , yerpe-y3224 , yerpe-YPLA , yerpe-YPO0180 , yerpe-YPO0667 , yerpe-YPO0773 , yerpe-YPO0986 , yerpe-YPO1501 , yerpe-YPO1997 , yerpe-YPO2526 , yerpe-YPO2814

Title : Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536 - Hochhut_2006_Mol.Microbiol_61_584
Author(s) : Hochhut B , Wilde C , Balling G , Middendorf B , Dobrindt U , Brzuszkiewicz E , Gottschalk G , Carniel E , Hacker J
Ref : Molecular Microbiology , 61 :584 , 2006
Abstract : The genome of uropathogenic Escherichia coli isolate 536 contains five well-characterized pathogenicity islands (PAIs) encoding key virulence factors of this strain. Except PAI IV(536), the four other PAIs of strain 536 are flanked by direct repeats (DRs), carry intact integrase genes and are able to excise site-specifically from the chromosome. Genome screening of strain 536 identified a sixth putative asnW-associated PAI. Despite the presence of DRs and an intact integrase gene, excision of this island was not detected. To investigate the role of PAI-encoded integrases for the recombination process the int genes of each unstable island of strain 536 were inactivated. For PAI I(536) and PAI II(536), their respective P4-like integrase was required for their excision. PAI III(536) carries two integrase genes, intA, encoding an SfX-like integrase, and intB, coding for an integrase with weak similarity to P4-like integrases. Only intB was required for site-specific excision of this island. For PAI V(536), excision could not be abolished after deleting its P4-like integrase gene but additional deletion of the PAI II(536)-specific integrase gene was required. Therefore, although all mediated by P4-like integrases, the activity of the PAI excision machinery is most often restricted to its cognate island. This work also demonstrates for the first time the existence of a cross-talk between integrases of different PAIs and shows that this cross-talk is unidirectional.
ESTHER : Hochhut_2006_Mol.Microbiol_61_584
PubMedSearch : Hochhut_2006_Mol.Microbiol_61_584
PubMedID: 16879640
Gene_locus related to this paper: ecoli-Aes , ecoli-rutD , ecoli-bioh , ecoli-C0410 , ecoli-C2429 , ecoli-C2451 , ecoli-C4836 , ecoli-dlhh , ecoli-entf , ecoli-fes , ecoli-IROD , ecoli-IROE , ecoli-pldb , ecoli-ptrb , ecoli-yafa , ecoli-yaim , ecoli-ybff , ecoli-ycfp , ecoli-ycjy , ecoli-yeiG , ecoli-YFBB , ecoli-yghX , ecoli-yhet , ecoli-yiel , ecoli-yjfp , ecoli-YNBC , ecoli-ypfh , ecoli-yqia , ecoli-YfhR , ecolx-q707d7 , yerpe-YBTT

Title : Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis - Chain_2004_Proc.Natl.Acad.Sci.U.S.A_101_13826
Author(s) : Chain PS , Carniel E , Larimer FW , Lamerdin J , Stoutland PO , Regala WM , Georgescu AM , Vergez LM , Land ML , Motin VL , Brubaker RR , Fowler J , Hinnebusch J , Marceau M , Medigue C , Simonet M , Chenal-Francisque V , Souza B , Dacheux D , Elliott JM , Derbise A , Hauser LJ , Garcia E
Ref : Proc Natl Acad Sci U S A , 101 :13826 , 2004
Abstract : Yersinia pestis, the causative agent of plague, is a highly uniform clone that diverged recently from the enteric pathogen Yersinia pseudotuberculosis. Despite their close genetic relationship, they differ radically in their pathogenicity and transmission. Here, we report the complete genomic sequence of Y. pseudotuberculosis IP32953 and its use for detailed genome comparisons with available Y. pestis sequences. Analyses of identified differences across a panel of Yersinia isolates from around the world reveal 32 Y. pestis chromosomal genes that, together with the two Y. pestis-specific plasmids, to our knowledge, represent the only new genetic material in Y. pestis acquired since the the divergence from Y. pseudotuberculosis. In contrast, 149 other pseudogenes (doubling the previous estimate) and 317 genes absent from Y. pestis were detected, indicating that as many as 13% of Y. pseudotuberculosis genes no longer function in Y. pestis. Extensive insertion sequence-mediated genome rearrangements and reductive evolution through massive gene loss, resulting in elimination and modification of preexisting gene expression pathways, appear to be more important than acquisition of genes in the evolution of Y. pestis. These results provide a sobering example of how a highly virulent epidemic clone can suddenly emerge from a less virulent, closely related progenitor.
ESTHER : Chain_2004_Proc.Natl.Acad.Sci.U.S.A_101_13826
PubMedSearch : Chain_2004_Proc.Natl.Acad.Sci.U.S.A_101_13826
PubMedID: 15358858
Gene_locus related to this paper: yerpe-BIOH , yerpe-dlhh , yerpe-IRP1 , yerpe-PIP , yerpe-PLDB , yerpe-PTRB , yerpe-Y0507 , yerpe-Y0644 , yerpe-y1616 , yerpe-y3224 , yerpe-YBTT , yerpe-YPLA , yerpe-YPO0180 , yerpe-YPO0667 , yerpe-YPO0773 , yerpe-YPO0776 , yerpe-YPO0986 , yerpe-YPO1501 , yerpe-YPO1997 , yerpe-YPO2002 , yerpe-YPO2336 , yerpe-YPO2526 , yerpe-YPO2638 , yerpe-YPO2814