DelVecchio_2002_Proc.Natl.Acad.Sci.U.S.A_99_443

Reference

Title : The genome sequence of the facultative intracellular pathogen Brucella melitensis - DelVecchio_2002_Proc.Natl.Acad.Sci.U.S.A_99_443
Author(s) : DelVecchio VG , Kapatral V , Redkar RJ , Patra G , Mujer C , Los T , Ivanova N , Anderson I , Bhattacharyya A , Lykidis A , Reznik G , Jablonski L , Larsen N , D'Souza M , Bernal A , Mazur M , Goltsman E , Selkov E , Elzer PH , Hagius S , O'Callaghan D , Letesson JJ , Haselkorn R , Kyrpides N , Overbeek R
Ref : Proc Natl Acad Sci U S A , 99 :443 , 2002
Abstract :

Brucella melitensis is a facultative intracellular bacterial pathogen that causes abortion in goats and sheep and Malta fever in humans. The genome of B. melitensis strain 16M was sequenced and found to contain 3,294,935 bp distributed over two circular chromosomes of 2,117,144 bp and 1,177,787 bp encoding 3,197 ORFs. By using the bioinformatics suite ERGO, 2,487 (78%) ORFs were assigned functions. The origins of replication of the two chromosomes are similar to those of other alpha-proteobacteria. Housekeeping genes, including those involved in DNA replication, transcription, translation, core metabolism, and cell wall biosynthesis, are distributed on both chromosomes. Type I, II, and III secretion systems are absent, but genes encoding sec-dependent, sec-independent, and flagella-specific type III, type IV, and type V secretion systems as well as adhesins, invasins, and hemolysins were identified. Several features of the B. melitensis genome are similar to those of the symbiotic Sinorhizobium meliloti.

PubMedSearch : DelVecchio_2002_Proc.Natl.Acad.Sci.U.S.A_99_443
PubMedID: 11756688
Gene_locus related to this paper: brume-BMEI0552 , brume-BMEI0733 , brume-BMEI1044 , brume-BMEI1119 , brume-BMEI1365 , brume-BMEI1594 , brume-BMEI1608 , brume-BMEI1822 , brume-BMEI1884 , brume-BMEI1951 , brume-BMEI2011 , brume-BMEII0047 , brume-BMEII0306 , brume-BMEII0681 , brume-BMEII0989 , brume-dhE2 , brume-PCAD , brusu-BR0288 , brusu-BR1291 , brusu-BR1327

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Citations formats

DelVecchio VG, Kapatral V, Redkar RJ, Patra G, Mujer C, Los T, Ivanova N, Anderson I, Bhattacharyya A, Lykidis A, Reznik G, Jablonski L, Larsen N, D'Souza M, Bernal A, Mazur M, Goltsman E, Selkov E, Elzer PH, Hagius S, O'Callaghan D, Letesson JJ, Haselkorn R, Kyrpides N, Overbeek R (2002)
The genome sequence of the facultative intracellular pathogen Brucella melitensis
Proc Natl Acad Sci U S A 99 :443

DelVecchio VG, Kapatral V, Redkar RJ, Patra G, Mujer C, Los T, Ivanova N, Anderson I, Bhattacharyya A, Lykidis A, Reznik G, Jablonski L, Larsen N, D'Souza M, Bernal A, Mazur M, Goltsman E, Selkov E, Elzer PH, Hagius S, O'Callaghan D, Letesson JJ, Haselkorn R, Kyrpides N, Overbeek R (2002)
Proc Natl Acad Sci U S A 99 :443