| Title : Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors - Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097 |
| Author(s) : Edmondson SD , Mastracchio A , Cox JM , Eiermann GJ , He H , Lyons KA , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Xu S , Zhu B , Thornberry NA , Roy RS , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 19 :4097 , 2009 |
|
Abstract :
A new series of DPP-4 inhibitors derived from piperidine-fused benzimidazoles and imidazopyridines is described. Optimization of this class of DPP-4 inhibitors led to the discovery of imidazopyridine 34. The potency, selectivity, cross-species DMPK profiles, and in vivo efficacy of 34 is reported. |
| PubMedSearch : Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097 |
| PubMedID: 19539471 |
| Gene_locus related to this paper: human-DPP4 |
| Inhibitor | Piperidine-fused-benzimidazole-25 Piperidine-fused-benzimidazole-34 |
| Gene_locus | human-DPP4 |
| Structure | 3HAB 3HAC |
Edmondson SD, Mastracchio A, Cox JM, Eiermann GJ, He H, Lyons KA, Patel RA, Patel SB, Petrov A, Scapin G, Wu JK, Xu S, Zhu B, Thornberry NA, Roy RS, Weber AE (2009)
Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors
Bioorganic & Medicinal Chemistry Lett
19 :4097
Edmondson SD, Mastracchio A, Cox JM, Eiermann GJ, He H, Lyons KA, Patel RA, Patel SB, Petrov A, Scapin G, Wu JK, Xu S, Zhu B, Thornberry NA, Roy RS, Weber AE (2009)
Bioorganic & Medicinal Chemistry Lett
19 :4097