| Title : Transforming an esterase into an enantioselective catecholase through bioconjugation of a versatile metal-chelating inhibitor - Fernandez-Lopez_2023_Chem.Commun.(Camb)__ |
| Author(s) : Fernandez-Lopez L , Cea-Rama I , Alvarez-Malmagro J , Ressmann AK , Gonzalez-Alfonso JL , Coscolin C , Shahgaldian P , Plou FJ , Modregger J , Pita M , Sanz-Aparicio J , Ferrer M |
| Ref : Chem Commun (Camb) , : , 2023 |
|
Abstract :
Metal complexes introduced into protein scaffolds can generate versatile biomimetic catalysts endowed with a variety of catalytic properties. Here, we synthesized and covalently bound a bipyridinyl derivative to the active centre of an esterase to generate a biomimetic catalyst that shows catecholase activity and enantioselective catalytic oxidation of (+)-catechin. |
| PubMedSearch : Fernandez-Lopez_2023_Chem.Commun.(Camb)__ |
| PubMedID: 37376994 |
| Gene_locus related to this paper: 9zzzz-a0a2k8jn75 |
| Inhibitor | 6RKY-K7K-phosphodiester ZK8 |
| Substrate | 3,5-Di-tert-butylcatechol |
| Gene_locus | 9zzzz-a0a2k8jn75 |
| Structure | 8PC7 |
Fernandez-Lopez L, Cea-Rama I, Alvarez-Malmagro J, Ressmann AK, Gonzalez-Alfonso JL, Coscolin C, Shahgaldian P, Plou FJ, Modregger J, Pita M, Sanz-Aparicio J, Ferrer M (2023)
Transforming an esterase into an enantioselective catecholase through bioconjugation of a versatile metal-chelating inhibitor
Chem Commun (Camb)
:
Fernandez-Lopez L, Cea-Rama I, Alvarez-Malmagro J, Ressmann AK, Gonzalez-Alfonso JL, Coscolin C, Shahgaldian P, Plou FJ, Modregger J, Pita M, Sanz-Aparicio J, Ferrer M (2023)
Chem Commun (Camb)
: