Glaser_2002_Mol.Microbiol_45_1499

Reference

Title : Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease - Glaser_2002_Mol.Microbiol_45_1499
Author(s) : Glaser P , Rusniok C , Buchrieser C , Chevalier F , Frangeul L , Msadek T , Zouine M , Couve E , Lalioui L , Poyart C , Trieu-Cuot P , Kunst F
Ref : Molecular Microbiology , 45 :1499 , 2002
Abstract :

Streptococcus agalactiae is a commensal bacterium colonizing the intestinal tract of a significant proportion of the human population. However, it is also a pathogen which is the leading cause of invasive infections in neonates and causes septicaemia, meningitis and pneumonia. We sequenced the genome of the serogroup III strain NEM316, responsible for a fatal case of septicaemia. The genome is 2 211 485 base pairs long and contains 2118 protein coding genes. Fifty-five per cent of the predicted genes have an ortholog in the Streptococcus pyogenes genome, representing a conserved backbone between these two streptococci. Among the genes in S. agalactiae that lack an ortholog in S. pyogenes, 50% are clustered within 14 islands. These islands contain known and putative virulence genes, mostly encoding surface proteins as well as a number of genes related to mobile elements. Some of these islands could therefore be considered as pathogenicity islands. Compared with other pathogenic streptococci, S. agalactiae shows the unique feature that pathogenicity islands may have an important role in virulence acquisition and in genetic diversity.

PubMedSearch : Glaser_2002_Mol.Microbiol_45_1499
PubMedID: 12354221
Gene_locus related to this paper: strag-ESTA , strag-GBS0040 , strag-GBS0107 , strag-GBS0567 , strag-GBS1828 , strag-GBS1967 , strag-pepx , strag-SAG0383 , strag-SAG0785 , strag-SAG0912 , strag-SAG1040 , strag-SAG1562 , strag-SAG2132

Related information

Gene_locus strag-ESTA    strag-GBS0040    strag-GBS0107    strag-GBS0567    strag-GBS1828    strag-GBS1967    strag-pepx    strag-SAG0383    strag-SAG0785    strag-SAG0912    strag-SAG1040    strag-SAG1562    strag-SAG2132
Gene_locus_frgt strag-ESTA    strag-GBS0040    strag-GBS0107    strag-GBS0567    strag-GBS1828    strag-GBS1967    strag-pepx    strag-SAG0383    strag-SAG0785    strag-SAG0912    strag-SAG1040    strag-SAG1562    strag-SAG2132    strag-SAG1022

Citations formats

Glaser P, Rusniok C, Buchrieser C, Chevalier F, Frangeul L, Msadek T, Zouine M, Couve E, Lalioui L, Poyart C, Trieu-Cuot P, Kunst F (2002)
Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease
Molecular Microbiology 45 :1499

Glaser P, Rusniok C, Buchrieser C, Chevalier F, Frangeul L, Msadek T, Zouine M, Couve E, Lalioui L, Poyart C, Trieu-Cuot P, Kunst F (2002)
Molecular Microbiology 45 :1499