Galanthamine
In 1951, the Russian pharmacologist Mikhail Mashkovsky discovered that local villagers from the Urals used the wild snowdrop (Galanthus spp., most notably Galanthus woronowii Losinsk.) to stave off paralysis in children suffering from poliomyelitis. The ethnobotanical use of the snowdrop in the Urals led to the isolation of galanthamine for the first time in 1952, an alkaloid with AChE-inhibiting propertiesAlkaloid from caucasian snow-drop Galenthus woronowii, the common snowdrop Galanthus nivalis Ungernia genus, Amaryllidaceae, from Narcissus spp. Selectivity for AChE. The CAS number of Galanthamine Hydrobromide is 1953-04-4. || Nivalin Reminyl trademark approved for treatment of Alzheimer disease in Austria. || Galantamine is a specific competitive and reversible aceylcholinesterase inhibitor. It is also an allosteric modulator at nicotinic cholinergic receptor sites potentiating cholinergic nicotinic neurotransmission at the ganglionic and the neuromuscular junctions.
General
Type : Derivative of Galanthamine, Natural, Alkaloid, Drug, Benzazepin, Azepane, Multitarget, Nicotinic agonist
Chemical_Nomenclature : 1,2,3,4,6,7,7a,11c-octahydro-9-methoxy-2methylbenzofuro[4,3,2-efg][2]benzazocin-6-ol
Canonical SMILES : CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)OC)O
InChI : InChI=1S\/C17H21NO3\/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17\/h3-6,12,14,19H,7-10H2,1-2H3\/t12-,14-,17-\/m0\/s1
InChIKey : ASUTZQLVASHGKV-JDFRZJQESA-N
Other name(s) : Galantamine || Lycoremine || Jilkon || Nivalin || Reminyl || Razadyne
MW : 287.35
Formula : C17H21NO3
CAS_number : 357-70-0
PubChem : 9651
UniChem : ASUTZQLVASHGKV-JDFRZJQESA-N
IUPHAR : 6693
Wikipedia : Galanthamine
Target
Families : Galanthamine ligand of proteins in family
ACHE
Structure :
1DX6
1QTI
1W6R
1W76
4EY6
Protein :
torca-ACHE
human-ACHE
References (89)
| Title : Galantamine for dementia due to Alzheimer's disease and mild cognitive impairment - Lim_2024_Cochrane.Database.Syst.Rev_11_Cd001747 |
| Author(s) : Lim AWY , Schneider L , Loy C |
| Ref : Cochrane Database Syst Rev , 11 :Cd001747 , 2024 |
| Abstract : |
| PubMedSearch : Lim_2024_Cochrane.Database.Syst.Rev_11_Cd001747 |
| PubMedID: 39498781 |
| Title : The Effect of Galantamine on Lipopolysaccharide-induced Acute Lung Injury During Neutropenia Recovery in Mice - Kwon_2024_In.Vivo_38_606 |
| Author(s) : Kwon OB , Seo W , Kim KY , Joo H , Yeo CD , Kim JW |
| Ref : In Vivo , 38 :606 , 2024 |
| Abstract : |
| PubMedSearch : Kwon_2024_In.Vivo_38_606 |
| PubMedID: 38418160 |
| Title : Cholinergic Crisis with Normal Serum Cholinesterase Levels due to Excessive Galantamine Ingestion: A Case Report - Suzuki_2024_Jma.j_7_292 |
| Author(s) : Suzuki A , Mayahara T , Katayama T , Arai H , Matsuura K , Nagata K , Maruo E |
| Ref : Jma j , 7 :292 , 2024 |
| Abstract : |
| PubMedSearch : Suzuki_2024_Jma.j_7_292 |
| PubMedID: 38721068 |
| Title : Evaluating the Efficacy of Chronic Galantamine on Sustained Attention and Cholinergic Neurotransmission in A Pre-Clinical Model of Traumatic Brain Injury - Moschonas_2024_J.Neurotrauma__ |
| Author(s) : Moschonas EH , Capeci HE , Annas EM , Domyslawski VB , Steber JA , Donald HM , Genkinger NR , Rennerfeldt PL , Bittner RA , Vozzella VJ , Cheng JP , Kline AE , Bondi CO |
| Ref : Journal of Neurotrauma , : , 2024 |
| Abstract : |
| PubMedSearch : Moschonas_2024_J.Neurotrauma__ |
| PubMedID: 38994598 |
| Title : A Comprehensive Analysis on Galantamine Based Hybrids for the Management of Alzheimer's Disease - Singh_2024_Chem.Biol.Drug.Des_104_e70004 |
| Author(s) : Singh YP , Prasad S , Kumar H |
| Ref : Chemical Biology Drug Des , 104 :e70004 , 2024 |
| Abstract : |
| PubMedSearch : Singh_2024_Chem.Biol.Drug.Des_104_e70004 |
| PubMedID: 39494477 |
| Title : Functionalized Graphene Quantum Dots as an Eco-Friendly Fluorescent Probe for Galantamine Analysis: Greenness Evaluation With Application to Pharmacokinetics Monitoring - Alosaimi_2024_Luminescence_39_e70060 |
| Author(s) : Alosaimi ME , Almalki AH , Abduljabbar MH , Alnemari RM , Alaqel SI , Serag A |
| Ref : Luminescence , 39 :e70060 , 2024 |
| Abstract : |
| PubMedSearch : Alosaimi_2024_Luminescence_39_e70060 |
| PubMedID: 39702891 |
| Title : A Comparative Study between Lycorine and Galantamine Abilities to Interact with AMYLOID beta and Reduce In Vitro Neurotoxicity - Kola_2023_Int.J.Mol.Sci_24_ |
| Author(s) : Kola A , Lamponi S , Curro F , Valensin D |
| Ref : Int J Mol Sci , 24 : , 2023 |
| Abstract : |
| PubMedSearch : Kola_2023_Int.J.Mol.Sci_24_ |
| PubMedID: 36768823 |
| Title : Static Binding and Dynamic Transporting-Based Design of Specific Ring-Chain-Ring Acetylcholinesterase Inhibitor: From Galantamine to Natural Product - Zhang_2023_Chemistry__e202203363 |
| Author(s) : Zhang Z , Lv J , Wang Y , Yu H , Guo B , Zhai J , Wang C , Zhao Y , Fan F , Luo W |
| Ref : Chemistry , :e202203363 , 2023 |
| Abstract : |
| PubMedSearch : Zhang_2023_Chemistry__e202203363 |
| PubMedID: 36826395 |
| Title : Protective Effect of Galantamine against Doxorubicin-Induced Neurotoxicity - Alsikhan_2023_Brain.Sci_13_ |
| Author(s) : Alsikhan RS , Aldubayan MA , Almami IS , Alhowail AH |
| Ref : Brain Sci , 13 : , 2023 |
| Abstract : |
| PubMedSearch : Alsikhan_2023_Brain.Sci_13_ |
| PubMedID: 37371449 |
| Title : Therapeutic and medicinal effects of snowdrop (Galanthus spp.) in Alzheimer's disease: A review - Babashpour-Asl_2023_J.Educ.Health.Promot_12_128 |
| Author(s) : Babashpour-Asl M , Kaboudi PS , Barez SR |
| Ref : J Educ Health Promot , 12 :128 , 2023 |
| Abstract : |
| PubMedSearch : Babashpour-Asl_2023_J.Educ.Health.Promot_12_128 |
| PubMedID: 37397105 |
| Title : Galantamine improves glycemic control and diabetic nephropathy in Lepr(db\/db) mice - Meng_2023_Sci.Rep_13_15544 |
| Author(s) : Meng Q , Ma J , Suo L , Pruekprasert N , Chakrapani P , Cooney RN |
| Ref : Sci Rep , 13 :15544 , 2023 |
| Abstract : |
| PubMedSearch : Meng_2023_Sci.Rep_13_15544 |
| PubMedID: 37731032 |
| Title : A Cobalt-Containing Compound as a Stronger Inhibitor than Galantamine to Inhibit Acetylcholinesterase Activity: A New Drug Candidate for Alzheimer's Disease Treatment - Kalari_2022_J.Alzheimers.Dis__ |
| Author(s) : Kalari M , Abbasi Z , Shasaltaneh MD , Khaleghian A , Moosavi-Nejad Z |
| Ref : J Alzheimers Dis , : , 2022 |
| Abstract : |
| PubMedSearch : Kalari_2022_J.Alzheimers.Dis__ |
| PubMedID: 35527546 |
| Title : Chemical Survey of Three Species of the Genus Rauhia Traub (Amaryllidaceae) - Tallini_2022_Plants.(Basel)_11_ |
| Author(s) : Tallini LR , Osorio EH , Berkov S , Torras-Claveria L , Rodriguez-Escobar ML , Viladomat F , Meerow AW , Bastida J |
| Ref : Plants (Basel) , 11 : , 2022 |
| Abstract : |
| PubMedSearch : Tallini_2022_Plants.(Basel)_11_ |
| PubMedID: 36559661 |
| Title : The Cholinergic Drug Galantamine Alleviates Oxidative Stress Alongside Anti-inflammatory and Cardio-Metabolic Effects in Subjects With the Metabolic Syndrome in a Randomized Trial - Sangaleti_2021_Front.Immunol_12_613979 |
| Author(s) : Sangaleti CT , Katayama KY , De Angelis K , Lemos de Moraes T , Araujo AA , Lopes HF , Camacho C , Bortolotto LA , Michelini LC , Irigoyen MC , Olofsson PS , Barnaby DP , Tracey KJ , Pavlov VA , Consolim Colombo FM |
| Ref : Front Immunol , 12 :613979 , 2021 |
| Abstract : |
| PubMedSearch : Sangaleti_2021_Front.Immunol_12_613979 |
| PubMedID: 33776997 |
| Title : Dextran Sodium Sulphate-Induced Gastrointestinal Injury Further Aggravates the Impact of Galantamine on the Gastric Myoelectric Activity in Experimental Pigs - Bures_2021_Pharmaceuticals.(Basel)_14_ |
| Author(s) : Bures J , Tacheci I , Kvetina J , Radochova V , Kohoutova D , Valis M , Rejchrt S , Knoblochova V , Karasova JZ |
| Ref : Pharmaceuticals (Basel) , 14 : , 2021 |
| Abstract : |
| PubMedSearch : Bures_2021_Pharmaceuticals.(Basel)_14_ |
| PubMedID: 34207410 |
| Title : Loss of Basal Forebrain Cholinergic Neurons Following Adolescent Binge Ethanol Exposure: Recovery With the Cholinesterase Inhibitor Galantamine - Crews_2021_Front.Behav.Neurosci_15_652494 |
| Author(s) : Crews FT , Fisher R , Deason C , Vetreno RP |
| Ref : Front Behavioral Neuroscience , 15 :652494 , 2021 |
| Abstract : |
| PubMedSearch : Crews_2021_Front.Behav.Neurosci_15_652494 |
| PubMedID: 33716687 |
| Title : Oral Pretreatment with Galantamine Effectively Mitigates the Acute Toxicity of a Supralethal Dose of Soman in Cynomolgus Monkeys Posttreated with Conventional Antidotes - Lane_2020_J.Pharmacol.Exp.Ther_375_115 |
| Author(s) : Lane M , Carter D , Pescrille JD , Aracava Y , Fawcett WP , Basinger GW , Pereira EFR , Albuquerque EX |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 375 :115 , 2020 |
| Abstract : |
| PubMedSearch : Lane_2020_J.Pharmacol.Exp.Ther_375_115 |
| PubMedID: 32759369 |
| Title : Gigantelline, gigantellinine and gigancrinine, cherylline- and crinine-type alkaloids isolated from Crinum jagus with anti-acetylcholinesterase activity - Ka_2020_Phytochemistry_175_112390 |
| Author(s) : Ka S , Masi M , Merindol N , Di Lecce R , Plourde MB , Seck M , Gorecki M , Pescitelli G , Desgagne-Penix I , Evidente A |
| Ref : Phytochemistry , 175 :112390 , 2020 |
| Abstract : |
| PubMedSearch : Ka_2020_Phytochemistry_175_112390 |
| PubMedID: 32335411 |
| Title : Galanthamine improves myocardial ischemia-reperfusion-induced cardiac dysfunction, endoplasmic reticulum stress-related apoptosis, and myocardial fibrosis by suppressing AMPK\/Nrf2 pathway in rats - Hou_2019_Ann.Transl.Med_7_634 |
| Author(s) : Hou X , Fu M , Cheng B , Kang Y , Xie D |
| Ref : Ann Transl Med , 7 :634 , 2019 |
| Abstract : |
| PubMedSearch : Hou_2019_Ann.Transl.Med_7_634 |
| PubMedID: 31930035 |
| Title : Nose to Brain Delivery of Galantamine Loaded Nanoparticles: In-vivo Pharmacodynamic and Biochemical Study in Mice - Sunena_2019_Curr.Drug.Deliv_16_51 |
| Author(s) : Sunena , Singh SK , Mishra DN |
| Ref : Curr Drug Deliv , 16 :51 , 2019 |
| Abstract : |
| PubMedSearch : Sunena_2019_Curr.Drug.Deliv_16_51 |
| PubMedID: 30289074 |
| Title : Double-Blind Placebo-Controlled Trial of Galantamine for Methadone-Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use - Carroll_2019_Am.J.Addict_28_238 |
| Author(s) : Carroll KM , DeVito EE , Yip SW , Nich C , Sofuoglu M |
| Ref : Am J Addict , 28 :238 , 2019 |
| Abstract : |
| PubMedSearch : Carroll_2019_Am.J.Addict_28_238 |
| PubMedID: 31165574 |
| Title : Post-Injury Administration of Galantamine Reduces Traumatic Brain Injury Pathology and Improves Outcome - Zhao_2018_J.Neurotrauma_35_362 |
| Author(s) : Zhao J , Hylin MJ , Kobori N , Hood KN , Moore AN , Dash PK |
| Ref : Journal of Neurotrauma , 35 :362 , 2018 |
| Abstract : |
| PubMedSearch : Zhao_2018_J.Neurotrauma_35_362 |
| PubMedID: 29088998 |
| Title : Neuroprotective Effects of Galantamine on Nerve Agent-Induced Neuroglial and Biochemical Changes - Golime_2018_Neurotox.Res_33_738 |
| Author(s) : Golime R , Palit M , Acharya J , Dubey DK |
| Ref : Neurotox Res , 33 :738 , 2018 |
| Abstract : |
| PubMedSearch : Golime_2018_Neurotox.Res_33_738 |
| PubMedID: 28929435 |
| Title : Cholinesterase-inhibitory effect and in silico analysis of alkaloids from bulbs of Hieronymiella species - Ortiz_2018_Phytomedicine_39_66 |
| Author(s) : Ortiz JE , Garro A , Pigni NB , Aguero MB , Roitman G , Slanis A , Enriz RD , Feresin GE , Bastida J , Tapia A |
| Ref : Phytomedicine , 39 :66 , 2018 |
| Abstract : |
| PubMedSearch : Ortiz_2018_Phytomedicine_39_66 |
| PubMedID: 29433685 |
| Title : Cooperative hydrogen bonds and mobility of the non-aromatic ring as selectivity determinants for human acetylcholinesterase to similar anti-Alzheimer's galantaminics: a computational study - Rocha_2018_J.Biomol.Struct.Dyn__1 |
| Author(s) : Rocha REO , Lima LHF |
| Ref : J Biomol Struct Dyn , :1 , 2018 |
| Abstract : |
| PubMedSearch : Rocha_2018_J.Biomol.Struct.Dyn__1 |
| PubMedID: 29697300 |
| Title : The Synthesis of Certain Derivatives and Analogues of (-)- and (+)-Galanthamine and an Assessment of their Capacities to Inhibit Acetylcholine Esterase - Buckler_2017_J.Org.Chem_82_7869 |
| Author(s) : Buckler JN , Taher ES , Fraser NJ , Willis AC , Carr PD , Jackson CJ , Banwell MG |
| Ref : J Org Chem , 82 :7869 , 2017 |
| Abstract : |
| PubMedSearch : Buckler_2017_J.Org.Chem_82_7869 |
| PubMedID: 28671462 |
| Title : Effects of Risperidone and Galantamine Treatment on Alzheimer's Disease Biomarker Levels in Cerebrospinal Fluid - Bloniecki_2017_J.Alzheimers.Dis_57_387 |
| Author(s) : Bloniecki V , Aarsland D , Blennow K , Cummings J , Falahati F , Winblad B , Freund-Levi Y |
| Ref : J Alzheimers Dis , 57 :387 , 2017 |
| Abstract : |
| PubMedSearch : Bloniecki_2017_J.Alzheimers.Dis_57_387 |
| PubMedID: 28269767 |
| Title : Advanced Structure-activity Relationships Applied to Mentha spicata L. Subsp. spicata Essential Oil Compounds as AChE and NMDA Ligands, in Comparison with Donepezil, Galantamine and Memantine - New Approach in Brain Disorders Pharmacology - Avram_2017_CNS.Neurol.Disord.Drug.Targets_16_800 |
| Author(s) : Avram S , Mernea M , Bagci E , Hritcu L , Borcan LC , Mihailescu DF |
| Ref : CNS Neurol Disord Drug Targets , 16 :800 , 2017 |
| Abstract : |
| PubMedSearch : Avram_2017_CNS.Neurol.Disord.Drug.Targets_16_800 |
| PubMedID: 28088901 |
| Title : Galanthamine, Plicamine, and Secoplicamine Alkaloids from Zephyranthes candida and Their Anti-acetylcholinesterase and Anti-inflammatory Activities - Zhan_2016_J.Nat.Prod_79_760 |
| Author(s) : Zhan G , Zhou J , Liu R , Liu T , Guo G , Wang J , Xiang M , Xue Y , Luo Z , Zhang Y , Yao G |
| Ref : Journal of Natural Products , 79 :760 , 2016 |
| Abstract : |
| PubMedSearch : Zhan_2016_J.Nat.Prod_79_760 |
| PubMedID: 26913788 |
| Title : Galanthamine decreases genotoxicity and cell death induced by beta-amyloid peptide in SH-SY5Y cell line - Castillo_2016_Neurotoxicol_57_291 |
| Author(s) : Castillo WO , Aristizabal-Pachon AF , de Lima Montaldi AP , Sakamoto-Hojo ET , Takahashi CS |
| Ref : Neurotoxicology , 57 :291 , 2016 |
| Abstract : |
| PubMedSearch : Castillo_2016_Neurotoxicol_57_291 |
| PubMedID: 27793617 |
| Title : Effect of Donepezil, Tacrine, Galantamine and Rivastigmine on Acetylcholinesterase Inhibition in Dugesia tigrina - Bezerra_2016_Molecules_21_ |
| Author(s) : Bezerra da Silva C , Pott A , Elifio-Esposito S , Dalarmi L , Fialho do Nascimento K , Moura Burci L , de Oliveira M , de Fatima Gaspari Dias J , Maria Warumby Zanin S , Gomes Miguel O , Dallarmi Miguel M |
| Ref : Molecules , 21 : , 2016 |
| Abstract : |
| PubMedSearch : Bezerra_2016_Molecules_21_ |
| PubMedID: 26760993 |
| Title : Efficacy of Galantamine on Cognition in Mild-to-Moderate Alzheimer's Dementia after Failure to Respond to Donepezil - Hwang_2016_Psychiatry.Investig_13_341 |
| Author(s) : Hwang TY , Ahn IS , Kim S , Kim DK |
| Ref : Psychiatry Investig , 13 :341 , 2016 |
| Abstract : |
| PubMedSearch : Hwang_2016_Psychiatry.Investig_13_341 |
| PubMedID: 27247602 |
| Title : Subthreshold Concentrations of Melatonin and Galantamine Improves Pathological AD-Hallmarks in Hippocampal Organotypic Cultures - Buendia_2016_Mol.Neurobiol_53_3338 |
| Author(s) : Buendia I , Parada E , Navarro E , Leon R , Negredo P , Egea J , Lopez MG |
| Ref : Molecular Neurobiology , 53 :3338 , 2016 |
| Abstract : |
| PubMedSearch : Buendia_2016_Mol.Neurobiol_53_3338 |
| PubMedID: 26081146 |
| Title : Docking-based Design of Galantamine Derivatives with Dual-site Binding to Acetylcholinesterase - Stavrakov_2016_Mol.Inform_35_278 |
| Author(s) : Stavrakov G , Philipova I , Zheleva D , Atanasova M , Konstantinov S , Doytchinova I |
| Ref : Mol Inform , 35 :278 , 2016 |
| Abstract : |
| PubMedSearch : Stavrakov_2016_Mol.Inform_35_278 |
| PubMedID: 27492242 |
| Title : Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment - Shao_2014_Brain.Res_1589_105 |
| Author(s) : Shao S , Li M , Du W , Shao F , Wang W |
| Ref : Brain Research , 1589 :105 , 2014 |
| Abstract : |
| PubMedSearch : Shao_2014_Brain.Res_1589_105 |
| PubMedID: 25281804 |
| Title : Galanthamine, an anti-cholinesterase drug, effects plant growth and development in Artemisia tridentata Nutt. via modulation of auxin and neurotransmitter signaling - Turi_2014_Plant.Signal.Behav_9_e28645 |
| Author(s) : Turi CE , Axwik KE , Smith A , Jones AM , Saxena PK , Murch SJ |
| Ref : Plant Signal Behav , 9 :e28645 , 2014 |
| Abstract : |
| PubMedSearch : Turi_2014_Plant.Signal.Behav_9_e28645 |
| PubMedID: 24690897 |
| Title : The prediction of response to Galantamine treatment in Patients with mild to moderate Alzheimer's Disease - Ohnishi_2014_Curr.Alzheimer.Res_11_110 |
| Author(s) : Ohnishi T , Sakiyama Y , Okuri Y , Kimura Y , Sugiyama N , Saito T , Takahashi M , Kobayashi T |
| Ref : Curr Alzheimer Res , 11 :110 , 2014 |
| Abstract : |
| PubMedSearch : Ohnishi_2014_Curr.Alzheimer.Res_11_110 |
| PubMedID: 24156269 |
| Title : Alkaloids from Habranthus tubispathus and H. jamesonii, two amaryllidaceae with acetyl- and butyrylcholinesterase inhibition activity - Cavallaro_2014_Nat.Prod.Commun_9_159 |
| Author(s) : Cavallaro V , Alza NP , Murray MG , Murray AP |
| Ref : Nat Prod Commun , 9 :159 , 2014 |
| Abstract : |
| PubMedSearch : Cavallaro_2014_Nat.Prod.Commun_9_159 |
| PubMedID: 24689279 |
| Title : Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity - Lopes_2013_Brain.Behav_3_67 |
| Author(s) : Lopes JP , Tarozzo G , Reggiani A , Piomelli D , Cavalli A |
| Ref : Brain Behav , 3 :67 , 2013 |
| Abstract : |
| PubMedSearch : Lopes_2013_Brain.Behav_3_67 |
| PubMedID: 23532860 |
| Title : Structures of human acetylcholinesterase in complex with pharmacologically important ligands - Cheung_2012_J.Med.Chem_55_10282 |
| Author(s) : Cheung J , Rudolph MJ , Burshteyn F , Cassidy MS , Gary EN , Love J , Franklin MC , Height JJ |
| Ref : Journal of Medicinal Chemistry , 55 :10282 , 2012 |
| Abstract : |
| PubMedSearch : Cheung_2012_J.Med.Chem_55_10282 |
| PubMedID: 23035744 |
| Gene_locus related to this paper: human-ACHE |
| Title : Wild Argentinian Amaryllidaceae, a New Renewable Source of the Acetylcholinesterase Inhibitor Galanthamine and Other Alkaloids - Ortiz_2012_Molecules_17_13473 |
| Author(s) : Ortiz JE , Berkov S , Pigni NB , Theoduloz C , Roitman G , Tapia A , Bastida J , Feresin GE |
| Ref : Molecules , 17 :13473 , 2012 |
| Abstract : |
| PubMedSearch : Ortiz_2012_Molecules_17_13473 |
| PubMedID: 23149565 |
| Title : GC-MS of amaryllidaceous galanthamine-type alkaloids - Berkov_2012_J.Mass.Spectrom_47_1065 |
| Author(s) : Berkov S , Viladomat F , Codina C , Suarez S , Ravelo A , Bastida J |
| Ref : J Mass Spectrom , 47 :1065 , 2012 |
| Abstract : |
| PubMedSearch : Berkov_2012_J.Mass.Spectrom_47_1065 |
| PubMedID: 22899516 |
| Title : Galanthamine plus estradiol treatment enhances cognitive performance in aged ovariectomized rats - Gibbs_2011_Horm.Behav_60_607 |
| Author(s) : Gibbs RB , Chipman AM , Hammond R , Nelson D |
| Ref : Horm Behav , 60 :607 , 2011 |
| Abstract : |
| PubMedSearch : Gibbs_2011_Horm.Behav_60_607 |
| PubMedID: 21889940 |
| Title : The dramatic effects of Galantamine in a patient with early-onset Alzheimer's disease - Dev_2010_Psychiatr.Danub_22_367 |
| Author(s) : Dev H , Agius M , Zaman R |
| Ref : Psychiatr Danub , 22 :367 , 2010 |
| Abstract : |
| PubMedSearch : Dev_2010_Psychiatr.Danub_22_367 |
| PubMedID: 20562785 |
| Title : Rapid TLC\/GC-MS identification of acetylcholinesterase inhibitors in alkaloid extracts - Berkov_2008_Phytochem.Anal_19_411 |
| Author(s) : Berkov S , Bastida J , Nikolova M , Viladomat F , Codina C |
| Ref : Phytochem Anal , 19 :411 , 2008 |
| Abstract : |
| PubMedSearch : Berkov_2008_Phytochem.Anal_19_411 |
| PubMedID: 18446766 |
| Title : Galanthamine, a natural product for the treatment of Alzheimer's disease - Marco_2006_Recent.Pat.CNS.Drug.Discov_1_105 |
| Author(s) : Marco L , do Carmo Carreiras M |
| Ref : Recent Pat CNS Drug Discov , 1 :105 , 2006 |
| Abstract : |
| PubMedSearch : Marco_2006_Recent.Pat.CNS.Drug.Discov_1_105 |
| PubMedID: 18221196 |
| Title : Choline pivaloyl ester strengthened the benefit effects of Tacrine and Galantamine on electroencephalographic and cognitive performances in nucleus basalis magnocellularis-lesioned and aged rats - Rispoli_2006_Pharmacol.Biochem.Behav_84_453 |
| Author(s) : Rispoli V , Marra R , Costa N , Scipione L , Rotiroti D , De Vita D , Liberatore F , Carelli V |
| Ref : Pharmacol Biochem Behav , 84 :453 , 2006 |
| Abstract : |
| PubMedSearch : Rispoli_2006_Pharmacol.Biochem.Behav_84_453 |
| PubMedID: 16859739 |
| Title : The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design - Greenblatt_2004_J.Am.Chem.Soc_126_15405 |
| Author(s) : Greenblatt HM , Guillou C , Guenard D , Argaman A , Botti SA , Badet B , Thal C , Silman I , Sussman JL |
| Ref : Journal of the American Chemical Society , 126 :15405 , 2004 |
| Abstract : |
| PubMedSearch : Greenblatt_2004_J.Am.Chem.Soc_126_15405 |
| PubMedID: 15563167 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Poster (77) Galanthamine inhibits the aggregation of the amyloid-beta-peptide stimulated by acetylcholinesterase in vitro. - |
| Author(s) : Dinamarca MC , Campos EO , Hancke JL , Rakonczay Z , Inestrosa NC |
| Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :361 , 2004 |
| PubMedID: |
| Title : Galanthamine from snowdrop--the development of a modern drug against Alzheimer's disease from local Caucasian knowledge - Heinrich_2004_J.Ethnopharmacol_92_147 |
| Author(s) : Heinrich M , Lee Teoh H |
| Ref : J Ethnopharmacol , 92 :147 , 2004 |
| Abstract : |
| PubMedSearch : Heinrich_2004_J.Ethnopharmacol_92_147 |
| PubMedID: 15137996 |
| Title : Galanthamine pattern in Narcissus confusus plants - Lopez_2003_Planta.Med_69_1166 |
| Author(s) : Lopez S , Bastida J , Viladomat F , Codina C |
| Ref : Planta Med , 69 :1166 , 2003 |
| Abstract : |
| PubMedSearch : Lopez_2003_Planta.Med_69_1166 |
| PubMedID: 14750039 |
| Title : Assessment of Health Economics in Alzheimer's Disease (AHEAD): Treatment with Galantamine in Sweden - Garfield_2002_Pharmacoeconomics_20_629 |
| Author(s) : Garfield FB , Getsios D , Caro JJ , Wimo A , Winblad B |
| Ref : Pharmacoeconomics , 20 :629 , 2002 |
| Abstract : |
| PubMedSearch : Garfield_2002_Pharmacoeconomics_20_629 |
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| Title : Acetylcholinesterase inhibitory activity of some Amaryllidaceae alkaloids and Narcissus extracts - Lopez_2002_Life.Sci_71_2521 |
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| Title : Three-dimensional structure of a complex of galanthamine (Nivalin) with acetylcholinesterase from Torpedo californica: implications for the design of new anti-Alzheimer drugs - Bartolucci_2001_Proteins_42_182 |
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| Gene_locus related to this paper: torca-ACHE |
| Title : Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning - Woodruff-Pak_2001_Proc.Natl.Acad.Sci.U.S.A_98_2089 |
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| Abstract : |
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| Title : Galantamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors: effects on the course of Alzheimer's disease - Coyle_2001_Biol.Psychiatry_49_289 |
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| Title : Galantamine: additional benefits to patients with Alzheimer's disease - Lilienfeld_2000_Dement.Geriatr.Cogn.Disord_11 Suppl 1_19 |
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| Title : Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension. The Galantamine USA-1 Study Group - Raskind_2000_Neurology_54_2261 |
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| Title : A 5-month, randomized, placebo-controlled trial of galantamine in AD. The Galantamine USA-10 Study Group - Tariot_2000_Neurology_54_2269 |
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| Title : Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts - Guillou_2000_Bioorg.Med.Chem.Lett_10_637 |
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| Ref : Bioorganic & Medicinal Chemistry Lett , 10 :637 , 2000 |
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| Title : Capillary zone electrophoresis determination of galanthamine in biological fluids and pharmaceutical preparatives: experimental design and artificial neural network optimization - Pokorna_1999_Electrophoresis_20_1993 |
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| Title : The O-demethylation of the antidementia drug galanthamine is catalysed by cytochrome P450 2D6 - Bachus_1999_Pharmacogenet_9_661 |
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| Title : Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution - Greenblatt_1999_FEBS.Lett_463_321 |
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| Gene_locus related to this paper: torca-ACHE |
| Title : Alzheimer's disease: seeking new ways to preserve brain function. Interview by Alice V. Luddington - Davis_1999_Geriatrics_54_42 |
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| Title : Effect of the acetylcholinesterase inhibitor galanthamine on learning and memory in prolonged alcohol intake rat model of acetylcholine deficit - Iliev_1999_Methods.Find.Exp.Clin.Pharmacol_21_297 |
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| Title : Potent acetylcholinesterase inhibitors: design, synthesis, and structure-activity relationships of bis-interacting ligands in the galanthamine series - Mary_1998_Bioorg.Med.Chem_6_1835 |
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| Title : Evaluation of four Narcissus cultivars as potential sources for galanthamine production [letter] - Moraes-Cerdeira_1997_Planta.Med_63_472 |
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| Title : Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine - Bores_1996_J.Pharmacol.Exp.Ther_277_728 |
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| Title : Galanthamine. [Review] [23 refs] - Fulton_1996_Drugs.Aging_9_60 |
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| Title : Effect of the cholinesterase-inhibiting substance galanthamine on evoked visual potentials in rats - Lewandowski_1995_Acta.Neurobiol.Experiment_55_141 |
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| Title : Physostigmine, galanthamine and codeine act as 'noncompetitive nicotinic receptor agonists' on clonal rat pheochromocytoma cells - Storch_1995_Eur.J.Pharmacol_290_207 |
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| Title : Homer's moly identified as Galanthus nivalis L.: physiologic antidote to stramonium poisoning - Plaitakis_1983_Clin.Neuropharmacol_6_1 |
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| Title : Studies on the synthesis of heterocyclic compounds. CCCXV. Modified total synthesis of (plus or minus)-galanthamine through phenol oxidation - |
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