| Title : Perfluorododecanoic acid exposure induced developmental neurotoxicity in zebrafish embryos - Guo_2018_Environ.Pollut_241_1018 |
| Author(s) : Guo X , Zhang S , Lu S , Zheng B , Xie P , Chen J , Li G , Liu C , Wu Q , Cheng H , Sang N |
| Ref : Environ Pollut , 241 :1018 , 2018 |
| Abstract : Perfluorododecanoic acid (PFDoA), an artificial perfluorochemical, has been widely distributed in different ambient media and has been reported to have the potential to cause developmental neurotoxicity. However, the specific mechanism is largely unknown. In the current study, zebrafish embryos were treated with 0, 0.24, 1.2, and 6mg/L PFDoA for 120h. Exposure to PFDoA causes serious decreases in hatching delay, body length, as well as decreased locomotor speed in zebrafish larvae. Additionally, the acetylcholine (ACh) content as well as acetylcholinesterase (AChE) activity were determined to be significantly downregulated in PFDoA treatment groups. The level of dopamine was upregulated significantly after treating with 1.2 and 6mg/L of PFDoA. Gene expressions related to the nervous system development were also analyzed, with the exception of the gene mesencephalic astrocyte-derived neurotrophic factor (manf), which is upregulated in the 6mg/L treatment group. All other genes were significantly downregulated in larvae in the PFDoA group in different degrees. In general, the results demonstrated that PFDoA exposure could result in the disruption of the cholinergic system, dopaminergic signaling, and the central nervous system. |
| ESTHER : Guo_2018_Environ.Pollut_241_1018 |
| PubMedSearch : Guo_2018_Environ.Pollut_241_1018 |
| PubMedID: 30029309 |
Guo X, Zhang S, Lu S, Zheng B, Xie P, Chen J, Li G, Liu C, Wu Q, Cheng H, Sang N (2018)
Perfluorododecanoic acid exposure induced developmental neurotoxicity in zebrafish embryos
Environ Pollut
241 :1018
Guo X, Zhang S, Lu S, Zheng B, Xie P, Chen J, Li G, Liu C, Wu Q, Cheng H, Sang N (2018)
Environ Pollut
241 :1018