Title : Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's beta-Amyloid Neurotoxicity Via the Inhibition of Abeta Fibrils Formation and Disaggregation of Preformed Fibrils - Hu_2015_CNS.Neurosci.Ther_21_953 |
Author(s) : Hu SQ , Wang R , Cui W , Mak SH , Li G , Hu YJ , Lee MY , Pang YP , Han YF |
Ref : CNS Neurosci Ther , 21 :953 , 2015 |
Abstract :
AIMS: Fibrillar aggregates of beta-amyloid protein (Abeta) are the main constituent of senile plaques and considered to be one of the causative events in the pathogenesis of Alzheimer's disease (AD). Compounds that could inhibit Abeta fibrils formation, disaggregate preformed Abeta fibrils as well as reduce their associated neurotoxicity might have therapeutic values for treating AD. In this study, the inhibitory effects of bis (heptyl)-cognitin (B7C), a multifunctional dimer derived from tacrine, on aggregation and neurotoxicity of Abeta1-40 were evaluated both in vitro and in vivo. |
PubMedSearch : Hu_2015_CNS.Neurosci.Ther_21_953 |
PubMedID: 26507365 |
Hu SQ, Wang R, Cui W, Mak SH, Li G, Hu YJ, Lee MY, Pang YP, Han YF (2015)
Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's beta-Amyloid Neurotoxicity Via the Inhibition of Abeta Fibrils Formation and Disaggregation of Preformed Fibrils
CNS Neurosci Ther
21 :953
Hu SQ, Wang R, Cui W, Mak SH, Li G, Hu YJ, Lee MY, Pang YP, Han YF (2015)
CNS Neurosci Ther
21 :953