Jackson_2009_Genome.Res_19_2231

Reference

Title : Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans - Jackson_2009_Genome.Res_19_2231
Author(s) : Jackson AP , Gamble JA , Yeomans T , Moran GP , Saunders D , Harris D , Aslett M , Barrell JF , Butler G , Citiulo F , Coleman DC , de Groot PW , Goodwin TJ , Quail MA , McQuillan J , Munro CA , Pain A , Poulter RT , Rajandream MA , Renauld H , Spiering MJ , Tivey A , Gow NA , Barrell B , Sullivan DJ , Berriman M
Ref : Genome Res , 19 :2231 , 2009
Abstract :

Candida dubliniensis is the closest known relative of Candida albicans, the most pathogenic yeast species in humans. However, despite both species sharing many phenotypic characteristics, including the ability to form true hyphae, C. dubliniensis is a significantly less virulent and less versatile pathogen. Therefore, to identify C. albicans-specific genes that may be responsible for an increased capacity to cause disease, we have sequenced the C. dubliniensis genome and compared it with the known C. albicans genome sequence. Although the two genome sequences are highly similar and synteny is conserved throughout, 168 species-specific genes are identified, including some encoding known hyphal-specific virulence factors, such as the aspartyl proteinases Sap4 and Sap5 and the proposed invasin Als3. Among the 115 pseudogenes confirmed in C. dubliniensis are orthologs of several filamentous growth regulator (FGR) genes that also have suspected roles in pathogenesis. However, the principal differences in genomic repertoire concern expansion of the TLO gene family of putative transcription factors and the IFA family of putative transmembrane proteins in C. albicans, which represent novel candidate virulence-associated factors. The results suggest that the recent evolutionary histories of C. albicans and C. dubliniensis are quite different. While gene families instrumental in pathogenesis have been elaborated in C. albicans, C. dubliniensis has lost genomic capacity and key pathogenic functions. This could explain why C. albicans is a more potent pathogen in humans than C. dubliniensis.

PubMedSearch : Jackson_2009_Genome.Res_19_2231
PubMedID: 19745113
Gene_locus related to this paper: canal-ATG15 , canal-c4yl13 , canal-ppme1 , canal-q5a0c9 , canal-q5ad17 , canal-q5ady2 , canal-q5ag57 , canal-q5ai12 , canal-q5akz5 , canal-q5apu4 , canal-q59m48 , canal-q59nw6 , candc-b9w8x6 , candc-b9w8x7 , candc-b9w905 , candc-b9wa64 , candc-b9wc27 , candc-b9wc30 , candc-b9wc93 , candc-b9wce3 , candc-b9wdh9 , candc-b9wds3 , candc-b9whs3 , candc-b9whs6 , candc-b9whv2 , candc-b9wi60 , candc-b9wid3 , candc-b9wje5 , candc-b9wk97 , candc-CduLAc , candc-b9wkf5 , candc-b9wkj1 , candc-b9wlf0 , candc-b9wmt8 , candc-b9wmx4 , candc-b9wc51 , candc-b9wa43 , candc-b9wl19 , candc-kex1

Related information

Gene_locus canal-ATG15    canal-c4yl13    canal-ppme1    canal-q5a0c9    canal-q5ad17    canal-q5ady2    canal-q5ag57    canal-q5ai12    canal-q5akz5    canal-q5apu4    canal-q59m48    canal-q59nw6    candc-b9w8x6    candc-b9w8x7    candc-b9w905    candc-b9wa64    candc-b9wc27    candc-b9wc30    candc-b9wc93    candc-b9wce3    candc-b9wdh9    candc-b9wds3    candc-b9whs3    candc-b9whs6    candc-b9whv2    candc-b9wi60    candc-b9wid3    candc-b9wje5    candc-b9wk97    candc-CduLAc    candc-b9wkf5    candc-b9wkj1    candc-b9wlf0    candc-b9wmt8    candc-b9wmx4    candc-b9wc51    candc-b9wa43    candc-b9wl19    candc-kex1

Citations formats

Jackson AP, Gamble JA, Yeomans T, Moran GP, Saunders D, Harris D, Aslett M, Barrell JF, Butler G, Citiulo F, Coleman DC, de Groot PW, Goodwin TJ, Quail MA, McQuillan J, Munro CA, Pain A, Poulter RT, Rajandream MA, Renauld H, Spiering MJ, Tivey A, Gow NA, Barrell B, Sullivan DJ, Berriman M (2009)
Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans
Genome Res 19 :2231

Jackson AP, Gamble JA, Yeomans T, Moran GP, Saunders D, Harris D, Aslett M, Barrell JF, Butler G, Citiulo F, Coleman DC, de Groot PW, Goodwin TJ, Quail MA, McQuillan J, Munro CA, Pain A, Poulter RT, Rajandream MA, Renauld H, Spiering MJ, Tivey A, Gow NA, Barrell B, Sullivan DJ, Berriman M (2009)
Genome Res 19 :2231