| Title : Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX - Karasova_2009_Neurotox.Res_16_356 |
| Author(s) : Karasova JZ , Bajgar J , Jun D , Pavlikova R , Kuca K |
| Ref : Neurotox Res , 16 :356 , 2009 |
| Abstract : The toxic effect of organophosphates is attributed to irreversible inhibition of acetylcholinesterase (AChE; EC 3.1.1.7), the enzyme that hydrolyses the neurotransmitter acetylcholine. Inhibition potency in vivo of one of the most toxic nerve agents--Russian VX (RVX;N,N-diethyl-2-[methyl-(2-methylpropoxy)phosphoryl]sulfanylethanamine) (1 x LD(50) dose administered intramuscularly, i.m.) was studied in rats. AChE in blood was inhibited by 50%, 3 min after i.m. RVX. Butylcholinesterase (BChE; EC 3.1.1.8) in plasma was inhibited less rapidly and only by 10-20%, 20 min after RVX. AChE and BChE activities in diaphragm were reduced only 35% and 15% at 30 min. While AChE and BChE activities were reduced only about 20% and 15%, respectively, the decline in activity was rapid, occurring within 3 min. These findings indicate that RVX most potently inhibits ChE outside the central nervous system. |
| ESTHER : Karasova_2009_Neurotox.Res_16_356 |
| PubMedSearch : Karasova_2009_Neurotox.Res_16_356 |
| PubMedID: 19728005 |
Karasova JZ, Bajgar J, Jun D, Pavlikova R, Kuca K (2009)
Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX
Neurotox Res
16 :356
Karasova JZ, Bajgar J, Jun D, Pavlikova R, Kuca K (2009)
Neurotox Res
16 :356