| Title : Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor - Kozlowski_2000_Bioorg.Med.Chem.Lett_10_2255 |
| Author(s) : Kozlowski JA , Lowe DB , Guzik HS , Zhou G , Ruperto VB , Duffy RA , McQuade R , Crosby G , Taylor LA , Billard W , Binch H , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 10 :2255 , 2000 |
|
Abstract :
Structure activity studies on [4-(phenylsulfonyl)phenyl]methylpiperazine led to the discovery of 4-cyclohexyl-alpha-[4-[[4-methoxyphenyl(S)-sufinyl]phenyl]-1-pi perazineacetonitrile, 1, an M2 selective muscarinic antagonist. Affinity at the cloned human M2 receptor was 2.7 nM; the M1/M2 selectivity is 40-fold. |
| PubMedSearch : Kozlowski_2000_Bioorg.Med.Chem.Lett_10_2255 |
| PubMedID: 11055332 |
Kozlowski JA, Lowe DB, Guzik HS, Zhou G, Ruperto VB, Duffy RA, McQuade R, Crosby G, Taylor LA, Billard W, Binch H, Lachowicz JE (2000)
Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor
Bioorganic & Medicinal Chemistry Lett
10 :2255
Kozlowski JA, Lowe DB, Guzik HS, Zhou G, Ruperto VB, Duffy RA, McQuade R, Crosby G, Taylor LA, Billard W, Binch H, Lachowicz JE (2000)
Bioorganic & Medicinal Chemistry Lett
10 :2255