| Title : Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity - Clader_2004_Bioorg.Med.Chem_12_319 |
| Author(s) : Clader JW , Billard W , Binch H, 3rd , Chen LY , Crosby G, Jr. , Duffy RA , Ford J , Kozlowski JA , Lachowicz JE , Li S , Liu C , McCombie SW , Vice S , Zhou G , Greenlee WJ |
| Ref : Bioorganic & Medicinal Chemistry , 12 :319 , 2004 |
| Abstract : |
| PubMedSearch : Clader_2004_Bioorg.Med.Chem_12_319 |
| PubMedID: 14723952 |
| Title : Improving the oral efficacy of CNS drug candidates: discovery of highly orally efficacious piperidinyl piperidine M2 muscarinic receptor antagonists - Wang_2002_J.Med.Chem_45_5415 |
| Author(s) : Wang Y , Chackalamannil S , Hu Z , Greenlee WJ , Clader J , Boyle CD , Kaminski JJ , Billard W , Binch H, 3rd , Crosby G , Ruperto V , Duffy RA , Cohen-Williams M , Coffin VL , Cox KA , Grotz DE , Lachowicz JE |
| Ref : Journal of Medicinal Chemistry , 45 :5415 , 2002 |
| Abstract : |
| PubMedSearch : Wang_2002_J.Med.Chem_45_5415 |
| PubMedID: 12459007 |
| Title : Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification - Boyle_2002_Bioorg.Med.Chem.Lett_12_3479 |
| Author(s) : Boyle CD , Vice SF , Campion J , Chackalamannil S , Lankin CM , McCombie SW , Billard W , Binch H, 3rd , Crosby G , Williams MC , Coffin VL , Cox KA , Grotz DE , Duffy RA , Ruperto V , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 12 :3479 , 2002 |
| Abstract : |
| PubMedSearch : Boyle_2002_Bioorg.Med.Chem.Lett_12_3479 |
| PubMedID: 12419388 |
| Title : Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands - Kozlowski_2002_Bioorg.Med.Chem.Lett_12_791 |
| Author(s) : Kozlowski JA , Zhou G , Tagat JR , Lin SI , McCombie SW , Ruperto VB , Duffy RA , McQuade RA , Crosby G , Taylor LA , Billard W , Binch H , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 12 :791 , 2002 |
| Abstract : |
| PubMedSearch : Kozlowski_2002_Bioorg.Med.Chem.Lett_12_791 |
| PubMedID: 11859004 |
| Title : Metabolic stabilization of benzylidene ketal M(2) muscarinic receptor antagonists via halonaphthoic acid substitution - Boyle_2001_Bioorg.Med.Chem.Lett_11_2311 |
| Author(s) : Boyle CD , Chackalamannil S , Clader JW , Greenlee WJ , Josien HB , Kaminski JJ , Kozlowski JA , McCombie SW , Nazareno DV , Tagat JR , Wang Y , Zhou G , Billard W , Binch H , Crosby G , Cohen-Williams M , Coffin VL , Cox KA , Grotz DE , Duffy RA , Ruperto V , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 11 :2311 , 2001 |
| Abstract : |
| PubMedSearch : Boyle_2001_Bioorg.Med.Chem.Lett_11_2311 |
| PubMedID: 11527721 |
| Title : Muscarinic agonists and antagonists in the treatment of Alzheimer's disease - Greenlee_2001_Farmaco_56_247 |
| Author(s) : Greenlee W , Clader J , Asberom T , McCombie S , Ford J , Guzik H , Kozlowski J , Li S , Liu C , Lowe D , Vice S , Zhao H , Zhou G , Billard W , Binch H , Crosby R , Duffy R , Lachowicz J , Coffin V , Watkins R , Ruperto V , Strader C , Taylor L , Cox K |
| Ref : Farmaco , 56 :247 , 2001 |
| Abstract : |
| PubMedSearch : Greenlee_2001_Farmaco_56_247 |
| PubMedID: 11421251 |
| Title : Facilitation of acetylcholine release and improvement in cognition by a selective M2 muscarinic antagonist, SCH 72788 - Lachowicz_2001_Life.Sci_68(22-23)_2585 |
| Author(s) : Lachowicz JE , Duffy RA , Ruperto V , Kozlowski J , Zhou G , Clader J , Billard W , Binch H, 3rd , Crosby G , Cohen-Williams M , Strader CD , Coffin V |
| Ref : Life Sciences , 68 :2585 , 2001 |
| Abstract : |
| PubMedSearch : Lachowicz_2001_Life.Sci_68(22-23)_2585 |
| PubMedID: 11392630 |
| Title : SCH 57790, a selective muscarinic M(2) receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals - Carey_2001_Eur.J.Pharmacol_431_189 |
| Author(s) : Carey GJ , Billard W , Binch H , Cohen-Williams M , Crosby G , Grzelak M , Guzik H , Kozlowski JA , Lowe DB , Pond AJ , Tedesco RP , Watkins RW , Coffin VL |
| Ref : European Journal of Pharmacology , 431 :189 , 2001 |
| Abstract : |
| PubMedSearch : Carey_2001_Eur.J.Pharmacol_431_189 |
| PubMedID: 11728425 |
| Title : Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists - Wang_2000_Bioorg.Med.Chem.Lett_10_2247 |
| Author(s) : Wang Y , Chackalamannil S , Hu Z , Clader JW , Greenlee W , Billard W , Binch H , Crosby G , Ruperto V , Duffy RA , McQuade R , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 10 :2247 , 2000 |
| Abstract : |
| PubMedSearch : Wang_2000_Bioorg.Med.Chem.Lett_10_2247 |
| PubMedID: 11055330 |
| Title : Benzylidene ketal derivatives as M2 muscarinic receptor antagonists - Boyle_2000_Bioorg.Med.Chem.Lett_10_2727 |
| Author(s) : Boyle CD , Chackalamannil S , Chen LY , Dugar S , Pushpavanam P , Billard W , Binch H, 3rd , Crosby G , Cohen-Williams M , Coffin VL , Duffy RA , Ruperto V , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 10 :2727 , 2000 |
| Abstract : |
| PubMedSearch : Boyle_2000_Bioorg.Med.Chem.Lett_10_2727 |
| PubMedID: 11133078 |
| Title : Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor - Kozlowski_2000_Bioorg.Med.Chem.Lett_10_2255 |
| Author(s) : Kozlowski JA , Lowe DB , Guzik HS , Zhou G , Ruperto VB , Duffy RA , McQuade R , Crosby G , Taylor LA , Billard W , Binch H , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 10 :2255 , 2000 |
| Abstract : |
| PubMedSearch : Kozlowski_2000_Bioorg.Med.Chem.Lett_10_2255 |
| PubMedID: 11055332 |