| Title : Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands - Kozlowski_2002_Bioorg.Med.Chem.Lett_12_791 |
| Author(s) : Kozlowski JA , Zhou G , Tagat JR , Lin SI , McCombie SW , Ruperto VB , Duffy RA , McQuade RA , Crosby G , Taylor LA , Billard W , Binch H , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 12 :791 , 2002 |
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Abstract :
A novel series of 2-(R)-methyl-substituted piperazines (e.g., 2) is described. They are potent M(2) selective ligands that have >100-fold selectivity versus the M(1) receptor. In the rat microdialysis assay, compound 14 showed significantly enchanced levels of acetylcholine after oral administration. |
| PubMedSearch : Kozlowski_2002_Bioorg.Med.Chem.Lett_12_791 |
| PubMedID: 11859004 |
Kozlowski JA, Zhou G, Tagat JR, Lin SI, McCombie SW, Ruperto VB, Duffy RA, McQuade RA, Crosby G, Taylor LA, Billard W, Binch H, Lachowicz JE (2002)
Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands
Bioorganic & Medicinal Chemistry Lett
12 :791
Kozlowski JA, Zhou G, Tagat JR, Lin SI, McCombie SW, Ruperto VB, Duffy RA, McQuade RA, Crosby G, Taylor LA, Billard W, Binch H, Lachowicz JE (2002)
Bioorganic & Medicinal Chemistry Lett
12 :791