| Title : On the universality of oxime Hl-7 - antidote for case of the nerve agent poisoning - Kuca_2011_Mil.Med.Sci.Lett_80_80 |
| Author(s) : Kuca K , Musilek K , Karasova J , Jun D , Soukup O , Pohanka M , Ghosh KK , Hrabinova M |
| Ref : Military Medical Science Letters , 80 :80 , 2011 |
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Abstract :
Searching for the universal oxime, which could be able to reactivate acetylcholinesterase inhibited by various nerve agents is still topic of high interest. In this contribution, oxime HL-7, that was thoroughly discussed in the last decade, is evaluated . Its universality was tested in vitro using the rat brain homogenate as a source of the cholinesterases. The main members of the nerve agent family (tabun, sarin, soman, cyclosarin and VX) were used for this purpose. As shown, oxime HL-7 was able to reactivate cholinesterases inhibited by all tested nerve agents with the exception of tabun. Hence, it could not be designated as the broad-spectrum reactivator. |
| PubMedSearch : Kuca_2011_Mil.Med.Sci.Lett_80_80 |
| PubMedID: |
| Reactivator | HLo-7 |
Kuca K, Musilek K, Karasova J, Jun D, Soukup O, Pohanka M, Ghosh KK, Hrabinova M (2011)
On the universality of oxime Hl-7 - antidote for case of the nerve agent poisoning
Military Medical Science Letters
80 :80
Kuca K, Musilek K, Karasova J, Jun D, Soukup O, Pohanka M, Ghosh KK, Hrabinova M (2011)
Military Medical Science Letters
80 :80