Musilek K

General

Full name : Musilek Kamil

First name : Kamil

Mail : Department of Toxicology\; Faculty of Military Health Sciences\; University of Defence\; Trebesska 1575\; 50001 Hradec Kralove

Zip Code :

City :

Country : Czech Republic

Email : kamil.musilek@uhk.cz

Phone : +420973251523

Fax :

Website : \/\/www.uhk.cz\/en\/person\/4327\/kamil-musilek

Directory :

References (145)

Title : BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS - Prchalova_2023_Biomed.Pharmacother_167_115490
Author(s) : Prchalova E , Sukupova M , Malinak D , Andrys R , Sivak L , Pekarik V , Skarka A , Svobodova J , Prchal L , Fresser L , Heger Z , Musilek K
Ref : Biomed Pharmacother , 167 :115490 , 2023
PubMedID: 37722189

Title : Strategies for enhanced bioavailability of oxime reactivators in the central nervous system - Prchalova_2023_Arch.Toxicol__
Author(s) : Prchalova E , Kohoutova Z , Knittelova K , Malinak D , Musilek K
Ref : Archives of Toxicology , : , 2023
PubMedID: 37642747

Title : Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents - Zorbaz_2022_Eur.J.Med.Chem_238_114377
Author(s) : Zorbaz T , Malinak D , Hofmanova T , Marakovic N , Zunec S , Hrvat NM , Andrys R , Psotka M , Zandona A , Svobodova J , Prchal L , Fingler S , Katalinic M , Kovarik Z , Musilek K
Ref : Eur Journal of Medicinal Chemistry , 238 :114377 , 2022
PubMedID: 35526478

Title : Toxicity, pharmacokinetics, and effectiveness of the ortho-chlorinated bispyridinium oxime, K870 - Karasova_2022_Food.Chem.Toxicol__113236
Author(s) : Karasova JZ , Kassa J , Hepnarova V , Pejchal J , Junova L , Andrys R , Malinak D , Bzonek P , Kohoutova Z , Musilek K
Ref : Food & Chemical Toxicology , :113236 , 2022
PubMedID: 35738326

Title : Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides - Kohoutova_2022_J.Enzyme.Inhib.Med.Chem_37_760
Author(s) : Kohoutova Z , Malinak D , Andrys R , Svobodova J , Psotka M , Schmidt M , Prchal L , Musilek K
Ref : J Enzyme Inhib Med Chem , 37 :760 , 2022
PubMedID: 35193448

Title : Effects of Charged Oxime Reactivators on the HK-2 Cell Line in Renal Toxicity Screening - Handl_2021_Chem.Res.Toxicol__
Author(s) : Handl J , Malinak D , Capek J , Andrys R , Rousarova E , Hauschke M , Bruckova L , Cesla P , Rousar T , Musilek K
Ref : Chemical Research in Toxicology , : , 2021
PubMedID: 33566584

Title : (+\/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease - Ismaili_2021_ACS.Chem.Neurosci__
Author(s) : Ismaili L , Monnin J , Etievant A , Arribas RL , Viejo L , Refouvelet B , Soukup O , Janockova J , Hepnarova V , Korabecny J , Kucera T , Jun D , Andrys R , Musilek K , Baguet A , Garcia-Frutos EM , De Simone A , Andrisano V , Bartolini M , de los Rios C , Marco-Contelles J , Haffen E
Ref : ACS Chem Neurosci , : , 2021
PubMedID: 33797877

Title : Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase - Jonczyk_2021_Biomolecules_11_
Author(s) : Jonczyk J , Kukulowicz J , Aatka K , Malawska B , Jung YS , Musilek K , Bajda M
Ref : Biomolecules , 11 : , 2021
PubMedID: 33513955

Title : Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates - Lee_2021_J.Enzyme.Inhib.Med.Chem_36_437
Author(s) : Lee HM , Andrys R , Jonczyk J , Kim K , Vishakantegowda AG , Malinak D , Skarka A , Schmidt M , Vaskova M , Latka K , Bajda M , Jung YS , Malawska B , Musilek K
Ref : J Enzyme Inhib Med Chem , 36 :437 , 2021
PubMedID: 33467931

Title : Determination of K869, a novel oxime reactivator of acetylcholinesterase, in rat body fluids and tissues by liquid-chromatography methods: Pharmacokinetic study - Vanova_2021_J.Pharm.Sci__
Author(s) : Vanova N , Hojna A , Pejchal J , Herman D , Malinak D , Prchalova E , Musilek K , Karasova JZ
Ref : J Pharm Sci , : , 2021
PubMedID: 33545185

Title : Development of versatile and potent monoquaternary reactivators of acetylcholinesterase - Gorecki_2021_Arch.Toxicol__
Author(s) : Gorecki L , Hepnarova V , Karasova JZ , Hrabinova M , Courageux C , Dias J , Kucera T , Kobrlova T , Muckova L , Prchal L , Malinak D , Jun D , Musilek K , Worek F , Nachon F , Soukup O , Korabecny J
Ref : Archives of Toxicology , : , 2021
PubMedID: 33517499

Title : Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy - Bautista-Aguilera_2020_Int.J.Mol.Sci_21_
Author(s) : Bautista-Aguilera OM , Ismaili L , Chioua M , Andrys R , Schmidt M , Bzonek P , Martinez-Grau MA , Beadle CD , Vetman T , Lopez-Munoz F , Iriepa I , Refouvelet B , Musilek K , Marco-Contelles J
Ref : Int J Mol Sci , 21 : , 2020
PubMedID: 32486316

Title : Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors - Gorecki_2020_ACS.Med.Chem.Lett_11_65
Author(s) : Gorecki L , Andrys R , Schmidt M , Kucera T , Psotka M , Svobodova B , Hrabcova V , Hepnarova V , Bzonek P , Jun D , Kuca K , Korabecny J , Musilek K
Ref : ACS Med Chem Lett , 11 :65 , 2020
PubMedID: 31938465

Title : Glycosylated-Imidazole Aldoximes as Reactivators of Pesticides Inhibited AChE: Synthesis and In-vitro Reactivation Study - Sharma_2020_Environ.Toxicol.Pharmacol__103454
Author(s) : Sharma R , Upadhyaya K , Gupta B , Ghosh KK , Tripathi RP , Musilek K , Kuca K
Ref : Environ Toxicol Pharmacol , :103454 , 2020
PubMedID: 32645360

Title : Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators - Malinak_2020_J.Enzyme.Inhib.Med.Chem_35_478
Author(s) : Malinak D , Dolezal R , Hepnarova V , Hozova M , Andrys R , Bzonek P , Racakova V , Korabecny J , Gorecki L , Mezeiova E , Psotka M , Jun D , Kuca K , Musilek K
Ref : J Enzyme Inhib Med Chem , 35 :478 , 2020
PubMedID: 31910701

Title : 1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy - Kapron_2020_J.Enzyme.Inhib.Med.Chem_35_993
Author(s) : Kapron B , Czarnomysy R , Wysokinski M , Andrys R , Musilek K , Angeli A , Supuran CT , Plech T
Ref : J Enzyme Inhib Med Chem , 35 :993 , 2020
PubMedID: 32253957

Title : An update on T-2 toxin and its modified forms: metabolism, immunotoxicity mechanism, and human exposure assessment - Wu_2020_Arch.Toxicol_94_3645
Author(s) : Wu Q , Qin Z , Kuca K , You L , Zhao Y , Liu A , Musilek K , Chrienova Z , Nepovimova E , Oleksak P , Wu W , Wang X
Ref : Archives of Toxicology , 94 :3645 , 2020
PubMedID: 32910237

Title : Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimes drugs dealing with cholinergic, amyloid and mitochondrial systems - Nepovimova_2020_Bioorg.Chem_107_104596
Author(s) : Nepovimova E , Svobodova L , Dolezal R , Hepnarova V , Junova L , Jun D , Korabecny J , Kucera T , Gazova Z , Motykova K , Kubackova J , Bednarikova Z , Janockova J , Jesus C , Cortes L , Pina J , Rostohar D , Serpa C , Soukup O , Aitken L , Hughes RE , Musilek K , Muckova L , Jost P , Chvojkova M , Vales K , Valis M , Chrienova Z , Chalupova K , Kuca K
Ref : Bioorg Chem , 107 :104596 , 2020
PubMedID: 33421953

Title : Reactivation potency of two novel oximes (K456 and K733) against paraoxon-inhibited acetyl and butyrylcholinesterase: In silico and in vitro models - Iqbal_2019_Chem.Biol.Interact_13ChEPon_310_108735
Author(s) : Iqbal A , Malik S , Nurulain SM , Musilek K , Kuca K , Kalasz H , Fatmi MQ
Ref : Chemico-Biological Interactions , 310 :108735 , 2019
PubMedID: 31276662

Title : Synthesis and Biological Evaluation of Novel Chromone+Donepezil Hybrids for Alzheimer's Disease Therapy - Malek_2019_Curr.Alzheimer.Res_16_815
Author(s) : Malek R , Refouvelet B , Benchekroun M , Iriepa I , Moraleda I , Andrys R , Musilek K , Marco-Contelles J , Ismaili L
Ref : Curr Alzheimer Res , 16 :815 , 2019
PubMedID: 31660831

Title : Pharmacokinetics of K117 and K127, two novel antidote candidates to treat Tabun poisoning - Tekes_2019_Chem.Biol.Interact_13ChEPon_310_108737
Author(s) : Tekes K , Karvaly G , Nurulain S , Kuca K , Musilek K , Adeghate E , Jung YS , Kalasz H
Ref : Chemico-Biological Interactions , 310 :108737 , 2019
PubMedID: 31279792

Title : Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation - Antonijevic_2019_Chem.Biol.Interact_13ChEPon_308_385
Author(s) : Antonijevic E , Musilek K , Kuca K , Djukic-Cosic D , Andjelkovic M , Djordjevic AB , Antonijevic B
Ref : Chemico-Biological Interactions , 308 :385 , 2019
PubMedID: 31141677

Title : Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes - Zorbaz_2019_Chem.Biol.Interact_13ChEPon_307_16
Author(s) : Zorbaz T , Malinak D , Kuca K , Musilek K , Kovarik Z
Ref : Chemico-Biological Interactions , 307 :16 , 2019
PubMedID: 31004594

Title : Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy - Pachon-Angona_2019_J.Enzyme.Inhib.Med.Chem_34_479
Author(s) : Pachon-Angona I , Refouvelet B , Andrys R , Martin H , Luzet V , Iriepa I , Moraleda I , Diez-Iriepa D , Oset-Gasque MJ , Marco-Contelles J , Musilek K , Ismaili L
Ref : J Enzyme Inhib Med Chem , 34 :479 , 2019
PubMedID: 30712420

Title : Oxime K203: a drug candidate for the treatment of tabun intoxication - Gorecki_2019_Arch.Toxicol_93_673
Author(s) : Gorecki L , Soukup O , Kucera T , Malinak D , Jun D , Kuca K , Musilek K , Korabecny J
Ref : Archives of Toxicology , 93 :673 , 2019
PubMedID: 30564897

Title : Some Possibilities to Study New Prophylactics against Nerve Agents - Bajgar_2019_Mini.Rev.Med.Chem_19_970
Author(s) : Bajgar J , Kassa J , Kucera T , Musilek K , Jun D , Kuca K
Ref : Mini Rev Med Chem , 19 :970 , 2019
PubMedID: 30827238

Title : Surface screening, molecular modeling and in vitro studies on the interactions of aflatoxin M1 and human enzymes acetyl- and butyrylcholinesterase - de Almeida_2019_Chem.Biol.Interact_13ChEPon_308_113
Author(s) : de Almeida JSFD , Cavalcante SFA , Dolezal R , Kuca K , Musilek K , Jun D , Franca TCC
Ref : Chemico-Biological Interactions , 308 :113 , 2019
PubMedID: 31100275

Title : Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain - Antonijevic_2018_Arch.Toxicol_92_745
Author(s) : Antonijevic E , Kotur-Stevuljevic J , Musilek K , Kosvancova A , Kuca K , Djukic-Cosic D , Spasojevic-Kalimanovska V , Antonijevic B
Ref : Archives of Toxicology , 92 :745 , 2018
PubMedID: 29098328

Title : A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase - Kuca_2018_BMC.Pharmacol.Toxicol_19_8
Author(s) : Kuca K , Musilek K , Jun D , Karasova JZ , Nepovimova E , Soukup O , Hrabinova M , Mikler J , Franca TCC , da Cunha EFF , de Castro AA , Valis M , Ramalho TC
Ref : BMC Pharmacol Toxicol , 19 :8 , 2018
PubMedID: 29467029

Title : Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings - Kuca_2018_Drug.Des.Devel.Ther_12_505
Author(s) : Kuca K , Karasova JZ , Soukup O , Kassa J , Novotna E , Sepsova V , Horova A , Pejchal J , Hrabinova M , Vodakova E , Jun D , Nepovimova E , Valis M , Musilek K
Ref : Drug Des Devel Ther , 12 :505 , 2018
PubMedID: 29563775

Title : Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon - Kuca_2018_Molecules_23_
Author(s) : Kuca K , Jun D , Junova L , Musilek K , Hrabinova M , da Silva JAV , Ramalho TC , Valko M , Wu Q , Nepovimova E , Franca TCC
Ref : Molecules , 23 : , 2018
PubMedID: 29735900

Title : In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley? - Soukup_2018_Med.Chem_14_281
Author(s) : Soukup O , Korabecny J , Malinak D , Nepovimova E , Pham NL , Musilek K , Hrabinova M , Hepnarova V , Dolezal R , Pavek P , Jost P , Kobrlova T , Jankockova J , Gorecki L , Psotka M , Nguyen TD , Box K , Outhwaite B , Ceckova M , Sorf A , Jun D , Kuca K
Ref : Med Chem , 14 :281 , 2018
PubMedID: 29332594

Title : Novel Group of AChE Reactivators-Synthesis, In Vitro Reactivation and Molecular Docking Study - Malinak_2018_Molecules_23_
Author(s) : Malinak D , Nepovimova E , Jun D , Musilek K , Kuca K
Ref : Molecules , 23 : , 2018
PubMedID: 30205495

Title : Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents - Zorbaz_2018_J.Med.Chem_61_10753
Author(s) : Zorbaz T , Malinak D , Marakovic N , Macek Hrvat N , Zandona A , Novotny M , Skarka A , Andrys R , Benkova M , Soukup O , Katalinic M , Kuca K , Kovarik Z , Musilek K
Ref : Journal of Medicinal Chemistry , 61 :10753 , 2018
PubMedID: 30383374

Title : A Review of the Synthesis of Quaternary Acetylcholinesterase Reactivators - Tsai_2021_J.Food.Drug.Anal_29_153
Author(s) : Malinak D , Korabecny J , Soukup O , Gorecki L , Nepovimova E , Psotka M , Dolezal R , Nguyen TD , Mezeiova E , Musilek K , Kuca K
Ref : Current Organic Chemistry , 22\ :1619 , 2018
PubMedID:

Title : In silico and in vitro evaluation of two novel oximes (K378 and K727) in comparison to K-27 and pralidoxime against paraoxon-ethyl intoxication - Arshad_2018_Toxicol.Mech.Methods_28_62
Author(s) : Arshad M , Fatmi MQ , Musilek K , Hussain A , Kuca K , Petroianu G , Kalasz H , Nurulain SM
Ref : Toxicol Mech Methods , 28 :62 , 2018
PubMedID: 28722512

Title : Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes - Antonijevic_2018_Food.Chem.Toxicol_121_224
Author(s) : Antonijevic E , Musilek K , Kuca K , Djukic-Cosic D , Curcic M , Miladinovic DC , Bulat Z , Antonijevic B
Ref : Food & Chemical Toxicology , 121 :224 , 2018
PubMedID: 30176309

Title : Molecular modeling studies on the interactions of aflatoxin B1 and its metabolites with the peripheral anionic site (PAS) of human acetylcholinesterase - de Almeida_2018_J.Biomol.Struct.Dyn__1
Author(s) : de Almeida JSFD , Cavalcante SFA , Dolezal R , Kuca K , Musilek K , Jun D , Franca TCC
Ref : J Biomol Struct Dyn , :1 , 2018
PubMedID: 29749305

Title : Molecular Modeling Studies on the Interactions of Aflatoxin B1 and Its Metabolites with Human Acetylcholinesterase. Part II: Interactions with the Catalytic Anionic Site (CAS) - de Almeida_2018_Toxins.(Basel)_10_
Author(s) : de Almeida JSFD , Dolezal R , Krejcar O , Kuca K , Musilek K , Jun D , Franca TCC
Ref : Toxins (Basel) , 10 : , 2018
PubMedID: 30257474

Title : Quantification through TLC-densitometric analysis, repellency and anticholinesterase activity of the homemade extract of Indian cloves - Affonso_2018_Biomed.Chromatogr_32_
Author(s) : Affonso RS , Lima JA , Lessa BM , Caetano JVO , Obara MT , Nobrega AB , Nepovimova E , Musilek K , Kuca K , Slana G , Franca TCC
Ref : Biomedical Chromatography , 32 : , 2018
PubMedID: 28913959

Title : HLo-7 - A review of acetylcholinesterase reactivator against organophosphorus intoxication - Psotka_2017_Mil.Med.Sci.Lett_86_70
Author(s) : Psotka M , Malinak D , Gorecki L , Nguyen TD , Soukup O , Jun D , Kuca K , Musilek K , Korabecny J
Ref : Military Medical Science Letters , 86 :70 , 2017
PubMedID:

Title : Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016) - Gorecki_2017_Expert.Opin.Ther.Pat_27_971
Author(s) : Gorecki L , Korabecny J , Musilek K , Nepovimova E , Malinak D , Kucera T , Dolezal R , Jun D , Soukup O , Kuca K
Ref : Expert Opin Ther Pat , 27 :971 , 2017
PubMedID: 28569609

Title : Pharmacokinetic profile of promising acetylcholinesterase reactivators K027 and K203 in experimental pigs - Karasova_2017_Toxicol.Lett_273_20
Author(s) : Karasova JZ , Kvetina J , Tacheci I , Radochova V , Musilek K , Kuca K , Bures J
Ref : Toxicol Lett , 273 :20 , 2017
PubMedID: 28343895

Title : Small Quaternary Inhibitors K298 and K524: Cholinesterases Inhibition, Absorption, Brain Distribution, and Toxicity - Karasova_2016_Neurotox.Res_29_267
Author(s) : Karasova JZ , Hroch M , Musilek K , Kuca K
Ref : Neurotox Res , 29 :267 , 2016
PubMedID: 26646154

Title : Oxime-mediated in vitro reactivation kinetic analysis of organophosphates-inhibited human and electric eel acetylcholinesterase - Sahu_2016_Toxicol.Mech.Methods__1
Author(s) : Sahu AK , Sharma R , Gupta B , Musilek K , Kuca K , Acharya J , Ghosh KK
Ref : Toxicol Mech Methods , :1 , 2016
PubMedID: 27101948

Title : Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase - Winter_2016_Toxicol.Lett_244_136
Author(s) : Winter M , Wille T , Musilek K , Kuca K , Thiermann H , Worek F
Ref : Toxicol Lett , 244 :136 , 2016
PubMedID: 26210933

Title : SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides - Gorecki_2016_Arch.Toxicol_90_2831
Author(s) : Gorecki L , Korabecny J , Musilek K , Malinak D , Nepovimova E , Dolezal R , Jun D , Soukup O , Kuca K
Ref : Archives of Toxicology , 90 :2831 , 2016
PubMedID: 27582056

Title : Monooxime Bispyridinium Reactivators Bearing Xylene Linker Synthesis and In Vitro Evaluation on Model of Organophosphate-Inhibited Acetylcholinesterase - Musilek_2016_Med.Chem_12_362
Author(s) : Musilek K , Hambalek J , Holas O , Dohnal V , Kuca K
Ref : Med Chem , 12 :362 , 2016
PubMedID: 26427931

Title : Therapeutic and reactivating efficacy of oximes K027 and K203 against a direct acetylcholinesterase inhibitor - Antonijevic_2016_Neurotoxicol_55_33
Author(s) : Antonijevic E , Musilek K , Kuca K , Djukic-Cosic D , Vucinic S , Antonijevic B
Ref : Neurotoxicology , 55 :33 , 2016
PubMedID: 27177985

Title : Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease - Benek_2016_ChemMedChem_11_1264
Author(s) : Benek O , Soukup O , Pasdiorova M , Hroch L , Sepsova V , Jost P , Hrabinova M , Jun D , Kuca K , Zala D , Ramsay RR , Marco-Contelles J , Musilek K
Ref : ChemMedChem , 11 :1264 , 2016
PubMedID: 26427608

Title : A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication - Nepovimova_2016_Toxicol.Res.(Camb)_5_1012
Author(s) : Nepovimova E , Korabecny J , Dolezal R , Nguyen TD , Jun D , Soukup O , Pasdiorova M , Jost P , Muckova L , Malinak D , Gorecki L , Musilek K , Kuca K
Ref : Toxicol Res (Camb) , 5 :1012 , 2016
PubMedID: 30090408

Title : Catalytic Soman Scavenging by the Y337A\/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes - Kovarik_2015_Chem.Res.Toxicol_28_1036
Author(s) : Kovarik Z , Macek Hrvat N , Katalinic M , Sit RK , Paradyse A , Zunec S , Musilek K , Fokin VV , Taylor P , Radic Z
Ref : Chemical Research in Toxicology , 28 :1036 , 2015
PubMedID: 25835984

Title : Development and validation of a FIA\/UV-vis method for pK determination of oxime based acetylcholinesterase reactivators - Musil_2015_J.Pharm.Biomed.Anal_117_240
Author(s) : Musil K , Florianova V , Bucek P , Dohnal V , Kuca K , Musilek K
Ref : J Pharm Biomed Anal , 117 :240 , 2015
PubMedID: 26386953

Title : Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE - Kuca_2015_Med.Chem_11_683
Author(s) : Kuca K , Hrabinova M , Jun D , Musilek K , Penhaker M , Krejcar O , Soukup O
Ref : Med Chem , 11 :683 , 2015
PubMedID: 25845909

Title : A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice - Kassa_2015_Toxicol.Mech.Methods_25_229
Author(s) : Kassa J , Sepsova V , Matouskova L , Horova A , Musilek K
Ref : Toxicol Mech Methods , 25 :229 , 2015
PubMedID: 25894563

Title : Ligand-based 3D QSAR analysis of reactivation potency of mono- and bis-pyridinium aldoximes toward VX-inhibited rat acetylcholinesterase - Dolezal_2015_J.Mol.Graph.Model_56_113
Author(s) : Dolezal R , Korabecny J , Malinak D , Honegr J , Musilek K , Kuca K
Ref : J Mol Graph Model , 56 :113 , 2015
PubMedID: 25588616

Title : Development and Structural Modifications of Cholinesterase Reactivators against Chemical Warfare Agents in Last Decade: A Review - Sharma_2015_Mini.Rev.Med.Chem_15_58
Author(s) : Sharma R , Gupta B , Singh N , Acharya JR , Musilek K , Kuca K , Ghosh KK
Ref : Mini Rev Med Chem , 15 :58 , 2015
PubMedID: 25441834

Title : Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase - Horn_2015_Arch.Toxicol_89_405
Author(s) : Horn G , Wille T , Musilek K , Kuca K , Thiermann H , Worek F
Ref : Archives of Toxicology , 89 :405 , 2015
PubMedID: 24912784

Title : A comparison of the reactivating and therapeutic efficacy of two newly developed oximes (K727 and K733) with oxime k203 and trimedoxime in tabun-poisoned rats and mice - Kassa_2015_Basic.Clin.Pharmacol.Toxicol_116_367
Author(s) : Kassa J , Sepsova V , Tumova M , Horova A , Musilek K
Ref : Basic Clin Pharmacol Toxicol , 116 :367 , 2015
PubMedID: 25225130

Title : The evaluation of the reactivating and therapeutic efficacy of two novel oximes (K361 and K378) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice - Kassa_2014_Toxicol.Mech.Methods_24_173
Author(s) : Kassa J , Sepsova V , Tumova M , Musilek K , Horova A
Ref : Toxicol Mech Methods , 24 :173 , 2014
PubMedID: 24295433

Title : From Pyridinium-based to Centrally Active Acetylcholinesterase Reactivators - Korabecny_2014_Mini.Rev.Med.Chem_14_215
Author(s) : Korabecny J , Soukup O , Dolezal R , Spilovska K , Nepovimova E , Andrs M , Nguyen TD , Jun D , Musilek K , Kucerova-Chlupacova M , Kuca K
Ref : Mini Rev Med Chem , 14 :215 , 2014
PubMedID: 24552265

Title : Preparation, in vitro screening and molecular modelling of monoquaternary compounds related to the selective acetylcholinesterase inhibitor BW284c51 - Benek_2014_Med.Chem_11_21
Author(s) : Benek O , Musilek K , Horova A , Dohnal V , Dolezal R , Kuca K
Ref : Med Chem , 11 :21 , 2014
PubMedID: 24773345

Title : The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinic receptor - Sepsova_2014_Physiol.Res_63_771
Author(s) : Sepsova V , Krusek J , Karasova JZ , Zemek F , Musilek K , Kuca K , Soukup O
Ref : Physiol Res , 63 :771 , 2014
PubMedID: 25157661

Title : Structural modifications of dicationic acetylcholinesterase reactivators studied under ion-pairing mechanism in reversed-phase liquid chromatography - Radulescu_2014_J.Sep.Sci_37_3024
Author(s) : Radulescu M , Kuca K , Musilek K , David V
Ref : J Sep Sci , 37 :3024 , 2014
PubMedID: 25141798

Title : Assessment of antidotal efficacy of cholinesterase reactivators against paraoxon: In vitro reactivation kinetics and physicochemical properties - Gupta_2014_Bioorg.Med.Chem.Lett_24_4743
Author(s) : Gupta B , Singh N , Sharma R , Foretic B , Musilek K , Kuca K , Acharya J , Satnami ML , Ghosh KK
Ref : Bioorganic & Medicinal Chemistry Lett , 24 :4743 , 2014
PubMedID: 25190468

Title : In vivo evaluation of cholinesterase activity, oxidative stress markers, cyto- and genotoxicity of K048 oxime-a promising antidote against organophosphate poisoning - Zunec_2014_Basic.Clin.Pharmacol.Toxicol_114_344
Author(s) : Zunec S , Kopjar N , Zeljezic D , Kuca K , Musilek K , Lucic Vrdoljak A
Ref : Basic Clin Pharmacol Toxicol , 114 :344 , 2014
PubMedID: 24741714

Title : 7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies - Korabecny_2014_Eur.J.Med.Chem_82C_426
Author(s) : Korabecny J , Dolezal R , Cabelova P , Horova A , Hruba E , Ricny J , Sedlacek L , Nepovimova E , Spilovska K , Andrs M , Musilek K , Opletalova V , Sepsova V , Ripova D , Kuca K
Ref : Eur Journal of Medicinal Chemistry , 82C :426 , 2014
PubMedID: 24929293

Title : HI-6 oxime (an acetylcholinesterase reactivator): blood plasma pharmacokinetics and organ distribution in experimental pigs - Kunes_2014_Neuro.Endocrinol.Lett_35_186
Author(s) : Kunes M , Kvetina J , Bures J , Karasova JZ , Pavlik M , Tacheci I , Musilek K , Kuca K
Ref : Neuro Endocrinol Lett , 35 :186 , 2014
PubMedID: 25638385

Title : Novel cholinesterase modulators and their ability to interact with DNA - Janockova_2013_Spectrochim.Acta.A.Mol.Biomol.Spectrosc_115C_364
Author(s) : Janockova J , Gulasova Z , Musilek K , Kuca K , Kozurkova M
Ref : Spectrochim Acta A Mol Biomol Spectrosc , 115C :364 , 2013
PubMedID: 23851179

Title : Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX - Kuca_2013_Med.Chem_9_689
Author(s) : Kuca K , Musilek K , Jun D , Karasova J , Soukup O , Pejchal J , Hrabinova M
Ref : Med Chem , 9 :689 , 2013
PubMedID: 22779796

Title : In silico pharmacophore modeling on known pyridinium oxime reactivators of cyclosarin (GF) inhibited AChE to Aid discovery of potential, more efficacious novel non-oxime reactivators - Bhattacharjee_2013_Curr.Comput.Aided.Drug.Des_9_402
Author(s) : Bhattacharjee AK , Musilek K , Kuca K
Ref : Curr Comput Aided Drug Des , 9 :402 , 2013
PubMedID: 23789829

Title : Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium\/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors - Komloova_2013_Bioorg.Med.Chem.Lett_23_6663
Author(s) : Komloova M , Horova A , Hrabinova M , Jun D , Dolezal M , Vinsova J , Kuca K , Musilek K
Ref : Bioorganic & Medicinal Chemistry Lett , 23 :6663 , 2013
PubMedID: 24220173

Title : The evaluation of the reactivating and therapeutic efficacy of three novel bispyridinium oximes (K454, K456, K458) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice - Kassa_2013_Toxicol.Mech.Methods_23_94
Author(s) : Kassa J , Sepsova V , Musilek K , Horova A
Ref : Toxicol Mech Methods , 23 :94 , 2013
PubMedID: 22901042

Title : Interaction of cholinesterase modulators with DNA and their cytotoxic activity - Janockova_2013_Int.J.Biol.Macromol_64C_53
Author(s) : Janockova J , Gulasova Z , Plsikova J , Musilek K , Kuca K , Mikes J , Culka L , Fedorocko P , Kozurkova M
Ref : Int J Biol Macromol , 64C :53 , 2013
PubMedID: 24296409

Title : 7-methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in alzheimer's disease treatment, synthesis, biological evaluation and molecular modeling studies - Spilovska_2013_Molecules_18_2397
Author(s) : Spilovska K , Korabecny J , Kral J , Horova A , Musilek K , Soukup O , Drtinova L , Gazova Z , Siposova K , Kuca K
Ref : Molecules , 18 :2397 , 2013
PubMedID: 23429378

Title : Prophylaxis and Post-exposure Treatment of Intoxications Caused by Nerve Agents and Organophosphorus Pesticides - Kuca_2013_Mini.Rev.Med.Chem_13_2102
Author(s) : Kuca K , Jun D , Musilek K , Pohanka M , Karasova JZ , Soukup O
Ref : Mini Rev Med Chem , 13 :2102 , 2013
PubMedID: 24195661

Title : A Resurrection of 7-MEOTA: A Comparison with Tacrine - Soukup_2013_Curr.Alzheimer.Res_10_893
Author(s) : Soukup O , Jun D , Karasova JZ , Patocka J , Musilek K , Korabecny J , Krusek J , Kaniakova M , Sepsova V , Mandikova J , Trejtnar F , Pohanka M , Drtinova L , Pavlik M , Tobin G , Kuca K
Ref : Curr Alzheimer Res , 10 :893 , 2013
PubMedID: 24093535

Title : Two possibilities how to increase the efficacy of antidotal treatment of nerve agent poisonings - Kassa_2012_Mini.Rev.Med.Chem_12_24
Author(s) : Kassa J , Musilek K , Karasova JZ , Kuca K , Bajgar J
Ref : Mini Rev Med Chem , 12 :24 , 2012
PubMedID: 22360668

Title : An in silico stereo-electronic comparison of conventional pyridinium oximes and K-oximes for organophosphate (OP) poisoning - Bhattacharjee_2012_Med.Chem_8_230
Author(s) : Bhattacharjee AK , Kuca K , Musilek K , Gordon RK
Ref : Med Chem , 8 :230 , 2012
PubMedID: 22385173

Title : Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase - Worek_2012_Arch.Toxicol_86_1379
Author(s) : Worek F , von der Wellen J , Musilek K , Kuca K , Thiermann H
Ref : Archives of Toxicology , 86 :1379 , 2012
PubMedID: 22437842

Title : The progress in the cholinesterase quantification methods - Holas_2012_Expert.Opin.Drug.Discov_7_1207
Author(s) : Holas O , Musilek K , Pohanka M , Kuca K
Ref : Expert Opin Drug Discov , 7 :1207 , 2012
PubMedID: 23013366

Title : A comparison of the efficacy of newly developed reversible inhibitors of acetylcholinesterase with commonly used pyridostigmine as pharmacological pre-treatment of soman-poisoned mice - Kassa_2012_Basic.Clin.Pharmacol.Toxicol_110_322
Author(s) : Kassa J , Musilek K , Koomlova M , Bajgar J
Ref : Basic Clin Pharmacol Toxicol , 110 :322 , 2012
PubMedID: 21981462

Title : [Tacrine and its derivatives in the therapy of Alzheimers disease] - Korabecny_2012_Ceska.Slov.Farm_61_210
Author(s) : Korabecny J , Spilovska K , Benek O , Musilek K , Soukup O , Kuca K
Ref : Ceska a Slovenska Farmacie , 61 :210 , 2012
PubMedID: 23256654

Title : Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128 - Musilek_2011_Bioorg.Med.Chem.Lett_21_150
Author(s) : Musilek K , Roder J , Komloova M , Holas O , Hrabinova M , Pohanka M , Dohnal V , Opletalova V , Kuca K , Jung YS
Ref : Bioorganic & Medicinal Chemistry Lett , 21 :150 , 2011
PubMedID: 21144749

Title : Method optimization for acetylcholinesterase modulators-albumin interactions - Zemek_2011_Mil.Med.Sci.Lett_80_58
Author(s) : Zemek F , Karasova JZ , Musilek K , Kuca K
Ref : Military Medical Science Letters , 80 :58 , 2011
PubMedID:

Title : On the universality of oxime Hl-7 - antidote for case of the nerve agent poisoning - Kuca_2011_Mil.Med.Sci.Lett_80_80
Author(s) : Kuca K , Musilek K , Karasova J , Jun D , Soukup O , Pohanka M , Ghosh KK , Hrabinova M
Ref : Military Medical Science Letters , 80 :80 , 2011
PubMedID:

Title : Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment - Komloova_2011_Bioorg.Med.Chem.Lett_21_2505
Author(s) : Komloova M , Musilek K , Horova A , Holas O , Dohnal V , Gunn-Moore F , Kuca K
Ref : Bioorganic & Medicinal Chemistry Lett , 21 :2505 , 2011
PubMedID: 21397501

Title : In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase - Jun_2011_Int.J.Mol.Sci_12_2077
Author(s) : Jun D , Musilova L , Musilek K , Kuca K
Ref : Int J Mol Sci , 12 :2077 , 2011
PubMedID: 21673941

Title : Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking - Musilek_2011_Bioorg.Med.Chem_19_754
Author(s) : Musilek K , Komloova M , Holas O , Horova A , Pohanka M , Gunn-Moore F , Dohnal V , Dolezal M , Kuca K
Ref : Bioorganic & Medicinal Chemistry , 19 :754 , 2011
PubMedID: 21215642

Title : Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment - Musilek_2011_Eur.J.Med.Chem_46_811
Author(s) : Musilek K , Komloova M , Holas O , Hrabinova M , Pohanka M , Dohnal V , Nachon F , Dolezal M , Kuca K
Ref : Eur Journal of Medicinal Chemistry , 46 :811 , 2011
PubMedID: 21236521

Title : The preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage - Musilek_2011_J.Enzyme.Inhib.Med.Chem_26_245
Author(s) : Musilek K , Pavlikova R , Marek J , Komloova M , Holas O , Hrabinova M , Pohanka M , Dohnal V , Dolezal M , Gunn-Moore F , Kuca K
Ref : J Enzyme Inhib Med Chem , 26 :245 , 2011
PubMedID: 21406034

Title : Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides - Musilek_2011_Med.Res.Rev_31_548
Author(s) : Musilek K , Dolezal M , Gunn-Moore F , Kuca K
Ref : Med Res Rev , 31 :548 , 2011
PubMedID: 20027669

Title : Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties - Korabecny_2011_Bioorg.Med.Chem.Lett_21_6563
Author(s) : Korabecny J , Musilek K , Zemek F , Horova A , Holas O , Nepovimova E , Opletalova V , Hroudova J , Fisar Z , Jung YS , Kuca K
Ref : Bioorganic & Medicinal Chemistry Lett , 21 :6563 , 2011
PubMedID: 21920739

Title : Monooxime-monocarbamoyl Bispyridinium Xylene-Linked Reactivators of Acetylcholinesterase-Synthesis, In vitro and Toxicity Evaluation, and Docking Studies - Musilek_2010_ChemMedChem_5_247
Author(s) : Musilek K , Holas O , Misik J , Pohanka M , Novotny L , Dohnal V , Opletalova V , Kuca K
Ref : ChemMedChem , 5 :247 , 2010
PubMedID: 20058292

Title : Is Oxime Fluorination the Proper Way to Increase Penetration of These Compounds in the Central Nervous System? - Karasova_2010_Mil.Med.Sci.Lett_79_23
Author(s) : Karasova JZ , Kassa J , Musilek K , Jung Y , Kuca K
Ref : Military Medical Science Letters , 79 :23 , 2010
PubMedID:

Title : Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications - Musilek_2010_Bioorg.Med.Chem.Lett_20_1763
Author(s) : Musilek K , Komloova M , Zavadova V , Holas O , Hrabinova M , Pohanka M , Dohnal V , Nachon F , Dolezal M , Kuca K , Jung YS
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :1763 , 2010
PubMedID: 20138518

Title : Passive diffusion of acetylcholinesterase oxime reactivators through the blood-brain barrier: influence of molecular structure - Karasova_2010_Toxicol.In.Vitro_24_1838
Author(s) : Karasova JZ , Pohanka M , Musilek K , Zemek F , Kuca K
Ref : Toxicol In Vitro , 24 :1838 , 2010
PubMedID: 20546883

Title : Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment - Korabecny_2010_Molecules_15_8804
Author(s) : Korabecny J , Musilek K , Holas O , Nepovimova E , Jun D , Zemek F , Opletalova V , Patocka J , Dohnal V , Nachon F , Hroudova J , Fisar Z , Kuca K
Ref : Molecules , 15 :8804 , 2010
PubMedID: 21127466

Title : A comparison of the reactivating and therapeutic efficacy of newly developed oximes (K347, K628) with commonly used oximes (obidoxime, HI-6) against tabun in rats and mice - Kassa_2010_Drug.Chem.Toxicol_33_227
Author(s) : Kassa J , Karasova JZ , Kuca K , Musilek K
Ref : Drug & Chemical Toxicology , 33 :227 , 2010
PubMedID: 20429807

Title : Structure-activity relationship of quaternary acetylcholinesterase inhibitors - outlook for early myasthenia gravis treatment - Komloova_2010_Curr.Med.Chem_17_1810
Author(s) : Komloova M , Musilek K , Dolezal M , Gunn-Moore F , Kuca K
Ref : Curr Med Chem , 17 :1810 , 2010
PubMedID: 20345342

Title : In silico pharmacophore model for tabun-inhibited acetylcholinesterase reactivators: a study of their stereoelectronic properties - Bhattacharjee_2010_Chem.Res.Toxicol_23_26
Author(s) : Bhattacharjee AK , Kuca K , Musilek K , Gordon RK
Ref : Chemical Research in Toxicology , 23 :26 , 2010
PubMedID: 20028185

Title : Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease - Korabecny_2010_Bioorg.Med.Chem.Lett_20_6093
Author(s) : Korabecny J , Musilek K , Holas O , Binder J , Zemek F , Marek J , Pohanka M , Opletalova V , Dohnal V , Kuca K
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :6093 , 2010
PubMedID: 20817518

Title : Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase - Kuca_2010_J.Enzyme.Inhib.Med.Chem_25_509
Author(s) : Kuca K , Musilek K , Jun D , Pohanka M , Ghosh KK , Hrabinova M
Ref : J Enzyme Inhib Med Chem , 25 :509 , 2010
PubMedID: 20192902

Title : Evaluation of aflatoxin B1--acetylcholinesterase dissociation kinetic using the amperometric biosensor technology: prospect for toxicity mechanism - Pohanka_2010_Protein.Pept.Lett_17_340
Author(s) : Pohanka M , Musilek K , Kuca K
Ref : Protein Pept Lett , 17 :340 , 2010
PubMedID: 19508188

Title : New Bisquaternary Inhibitors of Acetylcholinesterase Used as a Prophylactics in Organophosphorus Poisoning - Pavlikova_2010_Mil.Med.Sci.Lett_79_46
Author(s) : Pavlikova R , Marek J , Musilek K , Fusek J , Kuca K , Karasova JZ
Ref : Military Medical Science Letters , 79 :46 , 2010
PubMedID:

Title : A Comparison of Neuroprotective Efficacy of the Oxime K203 and its Fluorinated Analogue (KR-22836) with Obidoxime in Tabun-Poisoned Rats - Kassa_2010_Basic.Clin.Pharmacol.Toxicol_107_861
Author(s) : Kassa J , Karasova JZ , Tesarova S , Musilek K , Kuca K , Jung YS
Ref : Basic Clin Pharmacol Toxicol , 107 :861 , 2010
PubMedID: 22545968

Title : A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice - Kassa_2010_J.Enzyme.Inhib.Med.Chem_25_480
Author(s) : Kassa J , Karasova JZ , Caisberger F , Musilek K , Kuca K , Jung YS
Ref : J Enzyme Inhib Med Chem , 25 :480 , 2010
PubMedID: 20233085

Title : Evaluation of oxime k203 as antidote in tabun poisoning - Kovarik_2009_Arh.Hig.Rada.Toksikol_60_19
Author(s) : Kovarik Z , Vrdoljak AL , Zunec S , Katalinic M , Kuc K , Musilek K , Radic B
Ref : Arh Hig Rada Toksikol , 60 :19 , 2009
PubMedID: 19329372

Title : Effect of five acetylcholinesterase reactivators on tabun-intoxicated rats: induction of oxidative stress versus reactivation efficacy - Pohanka_2009_J.Appl.Toxicol_29_483
Author(s) : Pohanka M , Karasova JZ , Musilek K , Kuca K , Kassa J
Ref : J Appl Toxicol , 29 :483 , 2009
PubMedID: 19338015

Title : Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats - Karasova_2009_Int.J.Mol.Sci_10_3065
Author(s) : Karasova JZ , Kassa J , Musilek K , Pohanka M , Novotny L , Kuca K
Ref : Int J Mol Sci , 10 :3065 , 2009
PubMedID: 19742125

Title : Progress of biosensors based on cholinesterase inhibition - Pohanka_2009_Curr.Med.Chem_16_1790
Author(s) : Pohanka M , Musilek K , Kuca K
Ref : Curr Med Chem , 16 :1790 , 2009
PubMedID: 19442145

Title : A comparison of the neuroprotective efficacy of newly developed oximes (K117, K127) and currently available oxime (obidoxime) in tabun-poisoned rats - Kassa_2009_Toxicol.Mech.Methods_19_232
Author(s) : Kassa J , Karasova JZ , Musilek K , Kuca K , Jung AY
Ref : Toxicol Mech Methods , 19 :232 , 2009
PubMedID: 19730756

Title : Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127 - Kuca_2009_Basic.Clin.Pharmacol.Toxicol_105_207
Author(s) : Kuca K , Cabal J , Jung YS , Musilek K , Soukup O , Jun D , Pohanka M , Musilova L , Karasova J , Novotny L , Hrabinova M
Ref : Basic Clin Pharmacol Toxicol , 105 :207 , 2009
PubMedID: 19473310

Title : An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice - Kassa_2009_Clin.Toxicol.(Phila)_47_72
Author(s) : Kassa J , Karasova J , Musilek K , Kuca K , Bajgar J
Ref : Clinical Toxicology (Phila) , 47 :72 , 2009
PubMedID: 18686075

Title : Novel bisquaternary oximes--reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon - Kuca_2009_Molecules_14_4915
Author(s) : Kuca K , Musilova L , Palecek J , Cirkva V , Paar M , Musilek K , Hrabinova M , Pohanka M , Karasova JZ , Jun D
Ref : Molecules , 14 :4915 , 2009
PubMedID: 20032868

Title : Efficacy of eight experimental bispyridinium oximes against paraoxon-induced mortality: comparison with the conventional oximes pralidoxime and obidoxime - Nurulain_2009_Neurotox.Res_16_60
Author(s) : Nurulain SM , Lorke DE , Hasan MY , Shafiullah M , Kuca K , Musilek K , Petroianu GA
Ref : Neurotox Res , 16 :60 , 2009
PubMedID: 19526299

Title : Fluorinated pyridinium oximes as potential reactivators for acetylcholinesterases inhibited by paraoxon organophosphorus agent - Jeong_2009_Bioorg.Med.Chem_17_6213
Author(s) : Jeong HC , Park NJ , Chae CH , Musilek K , Kassa J , Kuca K , Jung YS
Ref : Bioorganic & Medicinal Chemistry , 17 :6213 , 2009
PubMedID: 19665386

Title : A comparison of reactivating and therapeutic efficacy of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice - Kassa_2009_Toxicol.Mech.Methods_19_346
Author(s) : Kassa J , Karasova JZ , Musilek K , Kuca K
Ref : Toxicol Mech Methods , 19 :346 , 2009
PubMedID: 19778210

Title : The development of new oximes and the evaluation of their reactivating, therapeutic and neuroprotective efficacy against tabun - Kassa_2008_Mini.Rev.Med.Chem_8_1134
Author(s) : Kassa J , Kuca K , Karasova J , Musilek K
Ref : Mini Rev Med Chem , 8 :1134 , 2008
PubMedID: 18855728

Title : A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice - Kassa_2008_Drug.Chem.Toxicol_31_371
Author(s) : Kassa J , Karasova J , Musilek K , Kuca K , Jung YS
Ref : Drug & Chemical Toxicology , 31 :371 , 2008
PubMedID: 18622871

Title : In vitro oxime protection of human red blood cell acetylcholinesterase inhibited by diisopropyl-fluorophosphate - Lorke_2008_J.Appl.Toxicol_28_422
Author(s) : Lorke DE , Hasan MY , Arafat K , Kuca K , Musilek K , Schmitt A , Petroianu GA
Ref : J Appl Toxicol , 28 :422 , 2008
PubMedID: 18344198

Title : Eight new bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime: in vivo efficacy to protect from diisopropylfluorophosphate toxicity - Lorke_2008_J.Appl.Toxicol_28_920
Author(s) : Lorke DE , Nurulain SM , Hasan MY , Kuca K , Musilek K , Petroianu GA
Ref : J Appl Toxicol , 28 :920 , 2008
PubMedID: 18548743

Title : RP-HPLC determination of the lipophilicity of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker - Musilek_2008_Anal.Bioanal.Chem_391_367
Author(s) : Musilek K , Jampilek J , Dohnal J , Jun D , Gunn-Moore F , Dolezal M , Kuca K
Ref : Anal Bioanal Chem , 391 :367 , 2008
PubMedID: 18369602

Title : Monoquaternary pyridinium salts with modified side chain-synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase - Musilek_2008_Bioorg.Med.Chem_16_8218
Author(s) : Musilek K , Kucera J , Jun D , Dohnal V , Opletalova V , Kuca K
Ref : Bioorganic & Medicinal Chemistry , 16 :8218 , 2008
PubMedID: 18676153

Title : Effect of several new and currently available oxime cholinesterase reactivators on tabun-intoxicated rats - Karasova_2008_Int.J.Mol.Sci_9_2243
Author(s) : Karasova JZ , Kassa J , Jung YS , Musilek K , Pohanka M , Kuca K
Ref : Int J Mol Sci , 9 :2243 , 2008
PubMedID: 19330072

Title : A comparison of the therapeutic and reactivating efficacy of newly developed bispyridinium compounds (K206, K269) with currently available oximes against tabun in rats and mice - Kassa_2008_J.Enzyme.Inhib.Med.Chem_23_776
Author(s) : Kassa J , Karasova J , Bajgar J , Kuca K , Musilek K
Ref : J Enzyme Inhib Med Chem , 23 :776 , 2008
PubMedID: 18608751

Title : The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder - Soukup_2008_Neuro.Endocrinol.Lett_29_759
Author(s) : Soukup O , Pohanka M , Tobin G , Jun D , Fusek J , Musilek K , Marek J , Kassa J , Kuca K
Ref : Neuro Endocrinol Lett , 29 :759 , 2008
PubMedID: 18987577

Title : Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase - Musilek_2008_J.Enzyme.Inhib.Med.Chem_23_70
Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Opletalova V , Dolezal M
Ref : J Enzyme Inhib Med Chem , 23 :70 , 2008
PubMedID: 18341256

Title : An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice - Kassa_2008_Toxicology_243_311
Author(s) : Kassa J , Karasova J , Musilek K , Kuca K
Ref : Toxicology , 243 :311 , 2008
PubMedID: 18054821

Title : Targeted synthesis of 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane dibromide--a new nerve agent reactivator - Kuca_2007_Molecules_12_1964
Author(s) : Kuca K , Musilek K , Paar M , Jun D , Stodulka P , Hrabinova M , Marek J
Ref : Molecules , 12 :1964 , 2007
PubMedID: 17960099

Title : Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203) - Musilek_2007_J.Med.Chem_50_5514
Author(s) : Musilek K , Jun D , Cabal J , Kassa J , Gunn-Moore F , Kuca K
Ref : Journal of Medicinal Chemistry , 50 :5514 , 2007
PubMedID: 17924614

Title : Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase - Musilek_2007_Bioorg.Med.Chem_15_6733
Author(s) : Musilek K , Holas O , Jun D , Dohnal V , Gunn-Moore F , Opletalova V , Dolezal M , Kuca K
Ref : Bioorganic & Medicinal Chemistry , 15 :6733 , 2007
PubMedID: 17764957

Title : Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX) - Musilek_2007_Acta.Medica.(Hradec.Kralove)_50_203
Author(s) : Musilek K , Kuca K , Jun D
Ref : Acta Medica (Hradec Kralove) , 50 :203 , 2007
PubMedID: 18254274

Title : In vitro reactivation potency of acetylcholinesterase reactivators--K074 and K075--to reactivate tabun-inhibited human brain cholinesterases - Kuca_2007_Neurotox.Res_11_101
Author(s) : Kuca K , Cabal J , Jun D , Musilek K
Ref : Neurotox Res , 11 :101 , 2007
PubMedID: 17449453

Title : Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker--synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase - Musilek_2007_Bioorg.Med.Chem.Lett_17_3172
Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Opletalova V , Dolezal M
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :3172 , 2007
PubMedID: 17383875

Title : Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase - Musilek_2007_J.Enzyme.Inhib.Med.Chem_22_425
Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Dolezal M
Ref : J Enzyme Inhib Med Chem , 22 :425 , 2007
PubMedID: 17847708

Title : Two step synthesis of a non-symmetric acetylcholinesterase reactivator - Musilek_2007_Molecules_12_1755
Author(s) : Musilek K , Kuca K , Dohnal V , Jun D , Marek J , Koleckar V
Ref : Molecules , 12 :1755 , 2007
PubMedID: 17960085

Title : Structural requirements of acetylcholinesterase reactivators - Kuca_2006_Mini.Rev.Med.Chem_6_269
Author(s) : Kuca K , Jun D , Musilek K
Ref : Mini Rev Med Chem , 6 :269 , 2006
PubMedID: 16515465

Title : New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin - Hrabinova_2006_J.Enzyme.Inhib.Med.Chem_21_515
Author(s) : Hrabinova M , Musilek K , Jun D , Kuca K
Ref : J Enzyme Inhib Med Chem , 21 :515 , 2006
PubMedID: 17194020

Title : Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase - Musilek_2006_Bioorg.Med.Chem.Lett_16_5673
Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Dolezal M
Ref : Bioorganic & Medicinal Chemistry Lett , 16 :5673 , 2006
PubMedID: 16934462

Title : Influence of Length and Shape of the Connecting Chain of Bisquaternary Acetylcholinesterase Reactivators on Their Potency to Reactivate Enzyme Inhibited by Sarin - Kuca_2006_Mil.Med.Sci.Lett_75_37
Author(s) : Kuca K , Jun D , Musilek K
Ref : Military Medical Science Letters , 75 :37 , 2006
PubMedID:

Title : Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase - Musilek_2006_Bioorg.Med.Chem.Lett_16_622
Author(s) : Musilek K , Kuca K , Jun D , Dohnal V , Dolezal M
Ref : Bioorganic & Medicinal Chemistry Lett , 16 :622 , 2006
PubMedID: 16288867

Title : [Synthesis of reactivators of phosphorylated acetylcholinesterase of bis-pyridiniumdialdoxime type with a 3-oxapentane connecting chain and their testing in vitro on a model of the enzyme inhibited by chlorpyrifos and methylchlorpyrifos] - Musilek_2006_Ceska.Slov.Farm_55_115
Author(s) : Musilek K , Kuca K , Jun D , Dohnal V , Kim TH , Jung YS , Dolezal M
Ref : Ceska a Slovenska Farmacie , 55 :115 , 2006
PubMedID: 16838488

Title : Effective bisquaternary reactivators of tabun-inhibited AChE - Kuca_2005_J.Appl.Toxicol_25_491
Author(s) : Kuca K , Cabal J , Musilek K , Jun D , Bajgar J
Ref : J Appl Toxicol , 25 :491 , 2005
PubMedID: 16092078

Title : Synthesis of a novel series of bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase - Musilek_2005_J.Enzyme.Inhib.Med.Chem_20_409
Author(s) : Musilek K , Kuca K , Jun D , Dohnal V , Dolezal M
Ref : J Enzyme Inhib Med Chem , 20 :409 , 2005
PubMedID: 16335048