Liu_2016_J.Med.Chem_59_5115

Reference

Title : Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors - Liu_2016_J.Med.Chem_59_5115
Author(s) : Liu Q , Chen X , Chen W , Yuan X , Su H , Shen J , Xu Y
Ref : Journal of Medicinal Chemistry , 59 :5115 , 2016
Abstract :

Lipoprotein-associated phospholipase A2 (Lp-PLA2) represents a promising therapeutic target for atherosclerosis and Alzheimer's disease. Here we reported the first crystal structures of Lp-PLA2 bound with reversible inhibitors and the thermodynamic characterization of complexes. High rigidity of Lp-PLA2 structure and similar binding modes of inhibitors with completely different scaffolds are revealed. It not only provides the molecular basis for inhibitory activity but also sheds light on the essential features of Lp-PLA2 recognition with reversible inhibitors.

PubMedSearch : Liu_2016_J.Med.Chem_59_5115
PubMedID: 27078579
Gene_locus related to this paper: human-PLA2G7

Related information

Inhibitor CHEMBL3792924
Gene_locus CHEMBL3792924    human-PLA2G7
Family CHEMBL3792924    human-PLA2G7    PAF-Acetylhydrolase
Structure CHEMBL3792924    human-PLA2G7    PAF-Acetylhydrolase    5I8P    5I9I

Citations formats

Liu Q, Chen X, Chen W, Yuan X, Su H, Shen J, Xu Y (2016)
Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors
Journal of Medicinal Chemistry 59 :5115

Liu Q, Chen X, Chen W, Yuan X, Su H, Shen J, Xu Y (2016)
Journal of Medicinal Chemistry 59 :5115