Title : Synthesis and Preliminary Evaluation of Phenyl 4-123I-Iodophenylcarbamate for Visualization of Cholinesterases Associated with Alzheimer Disease Pathology - Macdonald_2016_J.Nucl.Med_57_297 |
Author(s) : Macdonald IR , Reid GA , Pottie IR , Martin E , Darvesh S |
Ref : J Nucl Med , 57 :297 , 2016 |
Abstract :
Acetylcholinesterase and butyrylcholinesterase accumulate with brain beta-amyloid (Abeta) plaques in Alzheimer disease (AD). The overall activity of acetylcholinesterase is found to decline in AD, whereas butyrylcholinesterase has been found to either increase or remain the same. Although some cognitively normal older adults also have Abeta plaques within the brain, cholinesterase-associated plaques are generally less abundant in such individuals. Thus, brain imaging of cholinesterase activity associated with Abeta plaques has the potential to distinguish AD from cognitively normal older adults, with or without Abeta accumulation, during life. Current Abeta imaging agents are not able to provide this distinction. To address this unmet need, synthesis and evaluation of a cholinesterase-binding ligand, phenyl 4-(123)I-iodophenylcarbamate ((123)I-PIP), is described. |
PubMedSearch : Macdonald_2016_J.Nucl.Med_57_297 |
PubMedID: 26541777 |
Inhibitor | 123I-PIP |
Macdonald IR, Reid GA, Pottie IR, Martin E, Darvesh S (2016)
Synthesis and Preliminary Evaluation of Phenyl 4-123I-Iodophenylcarbamate for Visualization of Cholinesterases Associated with Alzheimer Disease Pathology
J Nucl Med
57 :297
Macdonald IR, Reid GA, Pottie IR, Martin E, Darvesh S (2016)
J Nucl Med
57 :297