1. Home
  2. Inhibitor
  3. 123I-PIP

123I-PIP

General

Type : Carbamate,PET probe

Chemical_Nomenclature : phenyl N-(4-iodophenyl)carbamate

Canonical SMILES : C1=CC=C(C=C1)OC(=O)NC2=CC=C(C=C2)I

InChI : InChI=1S\/C13H10INO2\/c14-10-6-8-11(9-7-10)15-13(16)17-12-4-2-1-3-5-12\/h1-9H,(H,15,16)

InChIKey : MWVJDZJEEOVQID-UHFFFAOYSA-N

Other name(s) : phenyl 4-(123)I-iodophenylcarbamate',((123)I-PIP)',Phenyl N-(4-iodophenyl)carbamate,phenyl 4-iodophenylcarbamate,SCHEMBL1171803,ZINC223932,AKOS008920262

MW : 339.13

Formula : C13H10INO2

CAS_number :

PubChem : 3634731

UniChem : MWVJDZJEEOVQID-UHFFFAOYSA-N

Target

Families : 123I-PIP ligand of proteins in family
BCHE

Protein :
human-BCHE

References (2)

Title : Imaging Butyrylcholinesterase in Multiple Sclerosis - Thorne_2021_Mol.Imaging.Biol_23_127
Author(s) : Thorne MWD , Cash MK , Reid GA , Burley DE , Luke D , Pottie IR , Darvesh S
Ref : Mol Imaging Biol , 23 :127 , 2021
Abstract : Thorne_2021_Mol.Imaging.Biol_23_127
ESTHER : Thorne_2021_Mol.Imaging.Biol_23_127
PubMedSearch : Thorne_2021_Mol.Imaging.Biol_23_127
PubMedID: 32926288

Title : Synthesis and Preliminary Evaluation of Phenyl 4-123I-Iodophenylcarbamate for Visualization of Cholinesterases Associated with Alzheimer Disease Pathology - Macdonald_2016_J.Nucl.Med_57_297
Author(s) : Macdonald IR , Reid GA , Pottie IR , Martin E , Darvesh S
Ref : J Nucl Med , 57 :297 , 2016
Abstract : Macdonald_2016_J.Nucl.Med_57_297
ESTHER : Macdonald_2016_J.Nucl.Med_57_297
PubMedSearch : Macdonald_2016_J.Nucl.Med_57_297
PubMedID: 26541777 
Array
(
    [id] => 1512
    [inhibitor] => 123I-PIP
    [type] => Array
        (
            [0] => Carbamate
            [1] => PET probe
        )

    [other_name] => Array
        (
            [0] => phenyl 4-(123)I-iodophenylcarbamate'
            [1] => ((123)I-PIP)'
            [2] => Phenyl N-(4-iodophenyl)carbamate
            [3] => phenyl 4-iodophenylcarbamate
            [4] => SCHEMBL1171803
            [5] => ZINC223932
            [6] => AKOS008920262
        )

    [chemical_nomenclature] => phenyl N-(4-iodophenyl)carbamate
    [formula] => C13H10INO2
    [cas_number] => 
    [mw] => 339.13
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Macdonald_2016_J.Nucl.Med_57_297 || Thorne_2021_Mol.Imaging.Biol_23_127
    [comment] => 
    [gene_locus] => human-BCHE
    [kin_inhibitor] => 
    [cid] => 3634731
    [family] => BCHE
    [inchikey] => MWVJDZJEEOVQID-UHFFFAOYSA-N
    [canonicalsmiles] => C1=CC=C(C=C1)OC(=O)NC2=CC=C(C=C2)I
    [inchi] => InChI=1S\/C13H10INO2\/c14-10-6-8-11(9-7-10)15-13(16)17-12-4-2-1-3-5-12\/h1-9H,(H,15,16)
    [wikipedia] => 
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)