| Title : Synthesis of organophosphates with fluorine-containing leaving groups as serine esterase inhibitors with potential for Alzheimer disease therapeutics - Makhaeva_2009_Bioorg.Med.Chem.Lett_19_5528 |
| Author(s) : Makhaeva GF , Aksinenko AY , Sokolov VB , Serebryakova OG , Richardson RJ |
| Ref : Bioorganic & Medicinal Chemistry Lett , 19 :5528 , 2009 |
| Abstract : Acetylcholinesterase and butyrylcholinesterase inhibitors are potential cognition enhancers in Alzheimer disease. O,O-Dialkylphosphate inhibitors with 1-substituted 2,2,2-trifluoroethoxy leaving groups were synthesized by phosphonate-phosphate rearrangement. Substituents in the 1-position of the leaving group along with the O-alkyl groups modulated potency and selectivity against acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. |
| ESTHER : Makhaeva_2009_Bioorg.Med.Chem.Lett_19_5528 |
| PubMedSearch : Makhaeva_2009_Bioorg.Med.Chem.Lett_19_5528 |
| PubMedID: 19717305 |
Makhaeva GF, Aksinenko AY, Sokolov VB, Serebryakova OG, Richardson RJ (2009)
Synthesis of organophosphates with fluorine-containing leaving groups as serine esterase inhibitors with potential for Alzheimer disease therapeutics
Bioorganic & Medicinal Chemistry Lett
19 :5528
Makhaeva GF, Aksinenko AY, Sokolov VB, Serebryakova OG, Richardson RJ (2009)
Bioorganic & Medicinal Chemistry Lett
19 :5528