| Title : Cholinergic agents: effect of methyl substitution in a series of arecoline derivatives on binding to muscarinic acetylcholine receptors - Moos_1992_J.Pharm.Sci_81_1015 |
| Author(s) : Moos WH , Bergmeier SC , Coughenour LL , Davis RE , Hershenson FM , Kester JA , McKee JS , Marriott JG , Schwarz RD , Tecle H , Thomas AJ |
| Ref : J Pharm Sci , 81 :1015 , 1992 |
| Abstract : Arecoline, arecaidine, and a series of derivatives, differing by the presence or absence of methyl groups at positions on the periphery of the molecule, were prepared, and their binding to muscarinic acetylcholine receptors was tested. On the basis of this study, muscarinic agonism for arecoline series is governed by strict structure-activity relationships, as previously observed for other agonist series. Only minor changes in nitrogen substitution were tolerated in the present series of arecoline derivatives. |
| ESTHER : Moos_1992_J.Pharm.Sci_81_1015 |
| PubMedSearch : Moos_1992_J.Pharm.Sci_81_1015 |
| PubMedID: 1432612 |
Moos WH, Bergmeier SC, Coughenour LL, Davis RE, Hershenson FM, Kester JA, McKee JS, Marriott JG, Schwarz RD, Tecle H, Thomas AJ (1992)
Cholinergic agents: effect of methyl substitution in a series of arecoline derivatives on binding to muscarinic acetylcholine receptors
J Pharm Sci
81 :1015
Moos WH, Bergmeier SC, Coughenour LL, Davis RE, Hershenson FM, Kester JA, McKee JS, Marriott JG, Schwarz RD, Tecle H, Thomas AJ (1992)
J Pharm Sci
81 :1015