Schwarz RD

General

Full name : Schwarz Roy D

First name : Roy D

Mail : Pfizer, Res Div, 2800 Plymouth Road, Ann Arbor. Michigan 48105

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Country : USA

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References (32)

Title : Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors - Bohme_2002_J.Med.Chem_45_3094
Author(s) : Bohme TM , Augelli-Szafran CE , Hallak H , Pugsley T , Serpa K , Schwarz RD
Ref : Journal of Medicinal Chemistry , 45 :3094 , 2002
PubMedID: 12086495

Title : Poster: Benzoxazine isoquinolines as M4 selective muscarinic receptor antagonists -
Author(s) : Schwarz RD , Bohme TM , Augelli-Szafran CE , Moreland DW
Ref : Life Sciences , 68 :2626 , 2001
PubMedID:

Title : Poster: Chronic administration of the M1 muscarinic agonist CI-1017 facilitates trace eyeblink conditioning in aging rabbits -
Author(s) : Weiss C , Schwarz RD , Disterhoft JF
Ref : Life Sciences , 68 :2641 , 2001
PubMedID:

Title : CI-1017, a functionally M1-selective muscarinic agonist: design, synthesis, and preclinical pharmacology - Tecle_2000_Pharm.Acta.Helv_74_141
Author(s) : Tecle H , Schwarz RD , Barrett SD , Callahan MJ , Caprathe BW , Davis RE , Doyle P , Emmerling M , Lauffer DJ , Mirzadegan T , Moreland DW , Lipiniski W , Nelson C , Raby C , Spencer C , Spiegel K , Thomas AJ , Jaen JC
Ref : Pharm Acta Helv , 74 :141 , 2000
PubMedID: 10812951

Title : Milameline (CI-979\/RU35926): a muscarinic receptor agonist with cognition-activating properties: biochemical and in vivo characterization - Schwarz_1999_J.Pharmacol.Exp.Ther_291_812
Author(s) : Schwarz RD , Callahan MJ , Coughenour LL , Dickerson MR , Kinsora JJ , Lipinski WJ , Raby CA , Spencer CJ , Tecle H
Ref : Journal of Pharmacology & Experimental Therapeutics , 291 :812 , 1999
PubMedID: 10525104

Title : Identification and characterization of m1 selective muscarinic receptor antagonists1 - Augelli-Szafran_1999_J.Med.Chem_42_356
Author(s) : Augelli-Szafran CE , Blankley CJ , Jaen JC , Moreland DW , Nelson CB , Penvose-Yi JR , Schwarz RD , Thomas AJ
Ref : Journal of Medicinal Chemistry , 42 :356 , 1999
PubMedID: 9986705

Title : Identification and characterization of m4 selective muscarinic antagonists - Augelli-Szafran_1998_Bioorg.Med.Chem.Lett_8_1991
Author(s) : Augelli-Szafran CE , Jaen JC , Moreland DW , Nelson CB , Penvose-Yi JR , Schwarz RD
Ref : Bioorganic & Medicinal Chemistry Lett , 8 :1991 , 1998
PubMedID: 9873472

Title : Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist - Tecle_1998_J.Med.Chem_41_2524
Author(s) : Tecle H , Barrett SD , Lauffer DJ , Augelli-Szafran C , Brann MR , Callahan MJ , Caprathe BW , Davis RE , Doyle PD , Eubanks D , Lipiniski W , Mirzadegan T , Moos WH , Moreland DW , Nelson CB , Pavia MR , Raby C , Schwarz RD , Spencer CJ , Thomas AJ , Jaen JC
Ref : Journal of Medicinal Chemistry , 41 :2524 , 1998
PubMedID: 9651157

Title : Poster: Pharmacological characterization of PD102807: An m4 subtype selective muscarinic antagonist -
Author(s) : Schwarz RD , Nelson CB , Augelli-Szafran CE , Penvose-Yi JR , Jaen JC , Wiley J , Frey KA
Ref : Life Sciences , 60 :1167 , 1997
PubMedID:

Title : Poster: Functional characterisation of PD102807: A novel M4-selective muscarinic antagonist -
Author(s) : Gross J , Augelli-Szafran CE , Czeche S , Friebe T , Jaen JC , Penvose-Yi JR , Schwarz RD , Mutschler E , Lambrecht G
Ref : Life Sciences , 60 :1168 , 1997
PubMedID:

Title : Poster: Identification and characterization of m4 selective muscarinic antagonists -
Author(s) : Augelli-Szafran CE , Moreland DW , Nelson CB , Penvose-Yi JR , Schwarz RD , Jaen JC
Ref : Life Sciences , 60 :1168 , 1997
PubMedID:

Title : Mutations of aspartate 103 in the Hm2 receptor and alterations in receptor binding properties of muscarinic agonists - Schwarz_1995_Life.Sci_56(11-12)_923
Author(s) : Schwarz RD , Spencer CJ , Jaen JC , Mirzadegan T , Moreland DW , Tecle H , Thomas AJ
Ref : Life Sciences , 56(11-12) :923 , 1995
PubMedID: 10188794

Title : Preclinical and phase 1 clinical characterization of CI-979\/RU35926, a novel muscarinic agonist for the treatment of Alzheimer's disease - Sedman_1995_Life.Sci_56(11-12)_877
Author(s) : Sedman AJ , Bockbrader H , Schwarz RD
Ref : Life Sciences , 56(11-12) :877 , 1995
PubMedID: 10188788

Title : Poster: Aryleneyne 1-azabicyclo[2.2.1]heptan-3-one oximes: Potent muscarinic agonists -
Author(s) : Tecle H , Lauffer DJ , Davis RE , Mirzadegan T , Moreland DW , Schwarz RD , Thomas AJ , Raby C , Jaen JC
Ref : Life Sciences , 56(11-12) :1003 , 1995
PubMedID:

Title : Poster: Identification and characterization of m1 selective muscarinic antagonists -
Author(s) : Augelli-Szafran CE , Blankley CJ , Jaen JC , Moreland DW , Nelson CB , Penvose JR , Schwarz RD , Thomas AJ
Ref : Life Sciences , 56(11-12) :1017 , 1995
PubMedID:

Title : Poster: Pharmacological characterization of PD150714: An m1 selective muscarinic antagonist -
Author(s) : Nelson CB , Augelli-Szafran CE , Callahan MJ , Christoffersen C , Jaen JC , Meltzer LT , Penvose JR , Schwarz RD , Thomas AJ , Wiley J
Ref : Life Sciences , 56(11-12) :1017 , 1995
PubMedID:

Title : Poster: Effect of mutating aspart ate 103 to glutamate or asparagine in the Hm2 subtype on binding of agonists and antagonists of varied pKa and subtype selectivity -
Author(s) : Spencer CJ , Schwarz RD , Moreland DW , Thomas AJ , Tecle H
Ref : Life Sciences , 56(11-12) :1020 , 1995
PubMedID:

Title : In vitro and in vivo evaluation of the subtype-selective muscarinic agonist PD 151832 - Jaen_1995_Life.Sci_56(11-12)_845
Author(s) : Jaen JC , Barrett S , Brann M , Callahan M , Davis R , Doyle P , Eubanks D , Lauffer DJ , Lauffer L , Lipinski W , Moreland DW , Nelson C , Raby C , Schwarz RD , Spencer CJ , Tecle H
Ref : Life Sciences , 56(11-12) :845 , 1995
PubMedID: 10188784

Title : Poster: Autoradiographic distinction of high and low affinity muscarinic receptors by the m1-selective ligand PD150714 -
Author(s) : Frey KA , Desmond T , Augelli-Szafran CE , Jaen JC , Schwarz RD
Ref : Life Sciences , 56(11-12) :1036 , 1995
PubMedID:

Title : PD 142676 (CI 1002), a novel anticholinesterase and muscarinic antagonist - Emmerling_1994_Mol.Neurobiol_9_93
Author(s) : Emmerling MR , Gregor VE , Schwarz RD , Scholten JD , Callahan MJ , Lee C , Moore CJ , Raby C , Lipinski WJ , Davis RE
Ref : Molecular Neurobiology , 9 :93 , 1994
PubMedID: 7888109

Title : Synthesis and SAR of bulky 1-azabicyclo[2.2.1]-3-one oximes as muscarinic receptor subtype selective agonists - Tecle_1993_Life.Sci_52(5-6)_505
Author(s) : Tecle H , Lauffer DJ , Mirzadegan T , Moos WH , Moreland DW , Pavia MR , Schwarz RD , Davis RE
Ref : Life Sciences , 52 :505 , 1993
PubMedID: 8382765

Title : Subtype selective muscarinic agonists: potential therapeutic agents for Alzheimer's disease -
Author(s) : Davis RD , Raby C , Callahan MJ , Lipinski W , Schwarz RD , Dudley DT , Lauffer DJ , Reece P , Jaen JC , Tecle H
Ref : Prog Brain Res , 98 :439 , 1993
PubMedID: 8248534

Title : Poster: Comparisons between human muscarinic receptor subtypes coupled to phospholipase C and those coupled to adenylyl cyclase: Effect of receptor reserve -
Author(s) : Lauffer L , Schwarz RD , Spencer CJ
Ref : Life Sciences , 52(5-6) :563 , 1993
PubMedID:

Title : Poster: Mutations of aspartate 103 in human muscarinic receptor subtype m2 expressed in cos-7 cells: Effects on receptor binding and signal transduction -
Author(s) : Spencer CJ , Schwarz RD , Lauffer L
Ref : Life Sciences , 52(5-6) :562 , 1993
PubMedID:

Title : Characterization of muscarinic agonists in recombinant cell lines - Schwarz_1993_Life.Sci_52(5-6)_465
Author(s) : Schwarz RD , Davis RE , Jaen JC , Spencer CJ , Tecle H , Thomas AJ
Ref : Life Sciences , 52 :465 , 1993
PubMedID: 8382764

Title : Cholinergic agents: effect of methyl substitution in a series of arecoline derivatives on binding to muscarinic acetylcholine receptors - Moos_1992_J.Pharm.Sci_81_1015
Author(s) : Moos WH , Bergmeier SC , Coughenour LL , Davis RE , Hershenson FM , Kester JA , McKee JS , Marriott JG , Schwarz RD , Tecle H , Thomas AJ
Ref : J Pharm Sci , 81 :1015 , 1992
PubMedID: 1432612

Title : Poster: Pharmacology of tacrine: comparisons with other cholinesterase inhibitors -
Author(s) : Davis RE , Coughenour LL , Dudley DT , Pugsley TA , Schwarz RD , Moos WH
Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :346 , 1991
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Title : Poster: Inhibition of rat acetyl- and butyrylcholinesterase activity by tacrine and related aminoacridines -
Author(s) : Schwarz RD , Spencer CJ , Davis RE , Moos WH , Pavia MR , Thomas AJ
Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :343 , 1991
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Title : A silica gel plate-based qualitative assay for acetylcholinesterase activity: a mass method to screen for potential inhibitors - Kiely_1991_Anal.Biochem_196_439
Author(s) : Kiely JS , Moos WH , Pavia MR , Schwarz RD , Woodard GL
Ref : Analytical Biochemistry , 196 :439 , 1991
PubMedID: 1663710

Title : Next generation tacrine -
Author(s) : Schwarz RD , Davis RE , Gracon S , Hoover T , Moos WH , Pavia MR
Ref : Neurobiology of Aging , 12 :185 , 1991
PubMedID: 2052133

Title : Poster: Muscarinic receptor binding, phosphatidylinositol (PI) turnover and Ca2+ mobilization in cells transformed to selectiveIy express rat m1 muscarinic receptors -
Author(s) : Schwarz RD , Coughenour LL , Dudley DT , Boyd DK , Fergus JH , Myers SL , Spencer CJ , Clark CR
Ref : Trends in Pharmacological Sciences , Suppl :116 , 1989
PubMedID:

Title : Control of the Release of [3H]-Acetylcholine from Rat Hippocampal Slices by Aminopyridines and Phencyclidine -
Author(s) : Schwarz RD , Spencer CJ , Bernabei AA , Pugsley TA
Ref : Advances in Behavioral Biology , 30 :653 , 1986
PubMedID: