| Title : CI-1017, a functionally M1-selective muscarinic agonist: design, synthesis, and preclinical pharmacology - Tecle_2000_Pharm.Acta.Helv_74_141 |
| Author(s) : Tecle H , Schwarz RD , Barrett SD , Callahan MJ , Caprathe BW , Davis RE , Doyle P , Emmerling M , Lauffer DJ , Mirzadegan T , Moreland DW , Lipiniski W , Nelson C , Raby C , Spencer C , Spiegel K , Thomas AJ , Jaen JC |
| Ref : Pharm Acta Helv , 74 :141 , 2000 |
| Abstract : |
| PubMedSearch : Tecle_2000_Pharm.Acta.Helv_74_141 |
| PubMedID: 10812951 |
| Title : Milameline (CI-979\/RU35926): a muscarinic receptor agonist with cognition-activating properties: biochemical and in vivo characterization - Schwarz_1999_J.Pharmacol.Exp.Ther_291_812 |
| Author(s) : Schwarz RD , Callahan MJ , Coughenour LL , Dickerson MR , Kinsora JJ , Lipinski WJ , Raby CA , Spencer CJ , Tecle H |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 291 :812 , 1999 |
| Abstract : |
| PubMedSearch : Schwarz_1999_J.Pharmacol.Exp.Ther_291_812 |
| PubMedID: 10525104 |
| Title : Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist - Tecle_1998_J.Med.Chem_41_2524 |
| Author(s) : Tecle H , Barrett SD , Lauffer DJ , Augelli-Szafran C , Brann MR , Callahan MJ , Caprathe BW , Davis RE , Doyle PD , Eubanks D , Lipiniski W , Mirzadegan T , Moos WH , Moreland DW , Nelson CB , Pavia MR , Raby C , Schwarz RD , Spencer CJ , Thomas AJ , Jaen JC |
| Ref : Journal of Medicinal Chemistry , 41 :2524 , 1998 |
| Abstract : |
| PubMedSearch : Tecle_1998_J.Med.Chem_41_2524 |
| PubMedID: 9651157 |
| Title : In vitro and in vivo evaluation of the subtype-selective muscarinic agonist PD 151832 - Jaen_1995_Life.Sci_56(11-12)_845 |
| Author(s) : Jaen JC , Barrett S , Brann M , Callahan M , Davis R , Doyle P , Eubanks D , Lauffer DJ , Lauffer L , Lipinski W , Moreland DW , Nelson C , Raby C , Schwarz RD , Spencer CJ , Tecle H |
| Ref : Life Sciences , 56(11-12) :845 , 1995 |
| Abstract : |
| PubMedSearch : Jaen_1995_Life.Sci_56(11-12)_845 |
| PubMedID: 10188784 |
| Title : Mutations of aspartate 103 in the Hm2 receptor and alterations in receptor binding properties of muscarinic agonists - Schwarz_1995_Life.Sci_56(11-12)_923 |
| Author(s) : Schwarz RD , Spencer CJ , Jaen JC , Mirzadegan T , Moreland DW , Tecle H , Thomas AJ |
| Ref : Life Sciences , 56(11-12) :923 , 1995 |
| Abstract : |
| PubMedSearch : Schwarz_1995_Life.Sci_56(11-12)_923 |
| PubMedID: 10188794 |
| Title : Poster: Aryleneyne 1-azabicyclo[2.2.1]heptan-3-one oximes: Potent muscarinic agonists - |
| Author(s) : Tecle H , Lauffer DJ , Davis RE , Mirzadegan T , Moreland DW , Schwarz RD , Thomas AJ , Raby C , Jaen JC |
| Ref : Life Sciences , 56(11-12) :1003 , 1995 |
| PubMedID: |
| Title : Poster: Effect of mutating aspart ate 103 to glutamate or asparagine in the Hm2 subtype on binding of agonists and antagonists of varied pKa and subtype selectivity - |
| Author(s) : Spencer CJ , Schwarz RD , Moreland DW , Thomas AJ , Tecle H |
| Ref : Life Sciences , 56(11-12) :1020 , 1995 |
| PubMedID: |
| Title : Characterization of muscarinic agonists in recombinant cell lines - Schwarz_1993_Life.Sci_52(5-6)_465 |
| Author(s) : Schwarz RD , Davis RE , Jaen JC , Spencer CJ , Tecle H , Thomas AJ |
| Ref : Life Sciences , 52 :465 , 1993 |
| Abstract : |
| PubMedSearch : Schwarz_1993_Life.Sci_52(5-6)_465 |
| PubMedID: 8382764 |
| Title : Synthesis and SAR of bulky 1-azabicyclo[2.2.1]-3-one oximes as muscarinic receptor subtype selective agonists - Tecle_1993_Life.Sci_52(5-6)_505 |
| Author(s) : Tecle H , Lauffer DJ , Mirzadegan T , Moos WH , Moreland DW , Pavia MR , Schwarz RD , Davis RE |
| Ref : Life Sciences , 52 :505 , 1993 |
| Abstract : |
| PubMedSearch : Tecle_1993_Life.Sci_52(5-6)_505 |
| PubMedID: 8382765 |
| Title : Poster: Molecular modeling studies of the m1 and m2 muscarinic receptors leading to the design of selective m1 agonists - |
| Author(s) : Mirzadegan T , Tecle H , Lauffer DJ , Humblet C |
| Ref : Life Sciences , 52(5-6) :561 , 1993 |
| PubMedID: |
| Title : Subtype selective muscarinic agonists: potential therapeutic agents for Alzheimer's disease - |
| Author(s) : Davis RD , Raby C , Callahan MJ , Lipinski W , Schwarz RD , Dudley DT , Lauffer DJ , Reece P , Jaen JC , Tecle H |
| Ref : Prog Brain Res , 98 :439 , 1993 |
| PubMedID: 8248534 |
| Title : Cholinergic agents: effect of methyl substitution in a series of arecoline derivatives on binding to muscarinic acetylcholine receptors - Moos_1992_J.Pharm.Sci_81_1015 |
| Author(s) : Moos WH , Bergmeier SC , Coughenour LL , Davis RE , Hershenson FM , Kester JA , McKee JS , Marriott JG , Schwarz RD , Tecle H , Thomas AJ |
| Ref : J Pharm Sci , 81 :1015 , 1992 |
| Abstract : |
| PubMedSearch : Moos_1992_J.Pharm.Sci_81_1015 |
| PubMedID: 1432612 |
| Title : Poster: CI-969: An orally active muscarinic receptor agonist related to arecoline - |
| Author(s) : Pavia MR , Schwarz AD , Coughenour LL , Davis RE , Dudley DT , Moos WH , Pugsley TA , Tecle H , Clark CA |
| Ref : Trends in Pharmacological Sciences , Suppl :100 , 1989 |
| PubMedID: |
| Title : Examination of a series of 8-[3-[bis(4-fluorophenyl)amino]propyl]-1-aryl-1,3,8- triazaspiro[4.5]decan-4-ones as potential antipsychotic agents - Wise_1985_J.Med.Chem_28_1811 |
| Author(s) : Wise LD , Pattison IC , Butler DE , DeWald HA , Lewis EP , Lobbestael SJ , Tecle H , Coughenour LL , Downs DA , Poschel BP |
| Ref : Journal of Medicinal Chemistry , 28 :1811 , 1985 |
| Abstract : |
| PubMedSearch : Wise_1985_J.Med.Chem_28_1811 |
| PubMedID: 2866248 |