Mushtaq_2014_Cell.Biochem.Funct_32_287

Reference

Title : Rosmarinic acid prevents lipid peroxidation and increase in acetylcholinesterase activity in brain of streptozotocin-induced diabetic rats - Mushtaq_2014_Cell.Biochem.Funct_32_287
Author(s) : Mushtaq N , Schmatz R , Pereira LB , Ahmad M , Stefanello N , Vieira JM , Abdalla F , Rodrigues MV , Baldissarelli J , Pelinson LP , Dalenogare DP , Reichert KP , Dutra EM , Mulinacci N , Innocenti M , Bellumori M , Morsch VM , Schetinger MR
Ref : Cell Biochemistry & Function , 32 :287 , 2014
Abstract :

We investigated the efficacy of rosmarinic acid (RA) in preventing lipid peroxidation and increased activity of acetylcholinesterase (AChE) in the brain of streptozotocin-induced diabetic rats. The animals were divided into six groups (n = 8): control, ethanol, RA 10 mg/kg, diabetic, diabetic/ethanol and diabetic/RA 10 mg/kg. After 21 days of treatment with RA, the cerebral structures (striatum, cortex and hippocampus) were removed for experimental assays. The results demonstrated that the treatment with RA (10 mg/kg) significantly reduced the level of lipid peroxidation in hippocampus (28%), cortex (38%) and striatum (47%) of diabetic rats when compared with the control. In addition, it was found that hyperglycaemia caused significant increased in the activity of AChE in hippocampus (58%), cortex (46%) and striatum (30%) in comparison with the control. On the other hand, the treatment with RA reversed this effect to the level of control after 3 weeks. In conclusion, the present findings showed that treatment with RA prevents the lipid peroxidation and consequently the increase in AChE activity in diabetic rats, demonstrating that this compound can modulate cholinergic neurotransmission and prevent damage oxidative in brain in the diabetic state. Thus, we can suggest that RA could be a promising compound in the complementary therapy in diabetes. Copyright (c) 2013 John Wiley & Sons, Ltd.

PubMedSearch : Mushtaq_2014_Cell.Biochem.Funct_32_287
PubMedID: 24301255

Related information

Inhibitor Rosmarinic-acid
Substrate Rosmarinic-acid

Citations formats

Mushtaq N, Schmatz R, Pereira LB, Ahmad M, Stefanello N, Vieira JM, Abdalla F, Rodrigues MV, Baldissarelli J, Pelinson LP, Dalenogare DP, Reichert KP, Dutra EM, Mulinacci N, Innocenti M, Bellumori M, Morsch VM, Schetinger MR (2014)
Rosmarinic acid prevents lipid peroxidation and increase in acetylcholinesterase activity in brain of streptozotocin-induced diabetic rats
Cell Biochemistry & Function 32 :287

Mushtaq N, Schmatz R, Pereira LB, Ahmad M, Stefanello N, Vieira JM, Abdalla F, Rodrigues MV, Baldissarelli J, Pelinson LP, Dalenogare DP, Reichert KP, Dutra EM, Mulinacci N, Innocenti M, Bellumori M, Morsch VM, Schetinger MR (2014)
Cell Biochemistry & Function 32 :287