| Title : Recent insights into the structure and function of comparative gene identification-58 - Oberer_2011_Curr.Opin.Lipidol_22_149 |
| Author(s) : Oberer M , Boeszoermenyi A , Nagy HM , Zechner R |
| Ref : Curr Opin Lipidol , 22 :149 , 2011 |
| Abstract : PURPOSE OF REVIEW: Comparative gene identification-58 (CGI-58) is an important player in lipid metabolism. It acts as activator of triglyceride hydrolases and as acyl-CoA-dependent lysophosphatidic acid acyltransferase. This review aims at establishing a structure-function relationship of this still rather enigmatic protein based on recent studies characterizing different functions of CGI-58. RECENT FINDINGS: Novel studies confirm the important regulatory role of CGI-58 as activator of the triglyceride hydrolase adipose triglyceride lipase. New evidence, corroborated by the characterization of a CGI-58 knockout mouse model, also suggests the existence of yet unknown lipases that are activated by CGI-58. Additionally, CGI-58 was identified to exert acyl-CoA-dependent lysophosphatidic acid acyltransferase activity, which implies possible roles in triglyceride or phospholipid synthesis or signaling processes. Unlike mammalian CGI-58 proteins, orthologs from plants and yeast additionally act as weak triglyceride and phospholipid hydrolases. A first three-dimensional model was calculated and allows preliminary structural considerations for the functions of CGI-58. SUMMARY: Despite important progress concerning the different biochemical functions of CGI-58, the physiological importance of these activities requires better characterization. Furthermore, three-dimensional structural data for CGI-58 are required to unveil the molecular mechanism of how CGI-58 acts as activator of lipases and exerts its enzymatic functions. |
| ESTHER : Oberer_2011_Curr.Opin.Lipidol_22_149 |
| PubMedSearch : Oberer_2011_Curr.Opin.Lipidol_22_149 |
| PubMedID: 21494142 |
| Gene_locus related to this paper: human-ABHD5 |
| Gene_locus related to this paper: human-ABHD5 |
Oberer M, Boeszoermenyi A, Nagy HM, Zechner R (2011)
Recent insights into the structure and function of comparative gene identification-58
Curr Opin Lipidol
22 :149
Oberer M, Boeszoermenyi A, Nagy HM, Zechner R (2011)
Curr Opin Lipidol
22 :149