Polidori_1990_Eur.J.Pharmacol_179_159

Reference

Title : Selective antagonists provide evidence that M1 muscarinic receptors may mediate carbachol-induced drinking in the rat - Polidori_1990_Eur.J.Pharmacol_179_159
Author(s) : Polidori C , Massi M , Lambrecht G , Mutschler E , Tacke R , Melchiorre C
Ref : European Journal of Pharmacology , 179 :159 , 1990
Abstract :

The present study served to investigate the ability of seven selective muscarinic antagonists to inhibit carbachol-induced drinking in the rat. The muscarinic antagonists were given by intracerebroventricular (i.c.v.) injection 1 min before the i.c.v. injection of carbachol (1 microgram/rat). The M2 antagonist, methoctramine, was inactive up to 80.3 nmol/rat. The M3 antagonist, p-fluoro-hexahydro-sila-difenidol, elicited a modest (42%) but statistically significant inhibition of drinking only at 80 nmol/rat. On the other hand, the selective M1 antagonists, (R)-trihexphenidyl, o-methoxy-sila-hexocyclium and pirenzepine, produced a marked and dose-dependent inhibition of carbachol-induced drinking, their ID50 values being 0.51, 7.36 and 9.31 nmol/rat. Also the M1/M3 antagonists, 4-diphenylacetoxy-N-methylpiperidine methiodide and hexahydro-sila-difenidol, were potent inhibitors of carbachol-induced drinking, their ID50 values (0.28 and 11.09 nmol/rat) being related to their pA2 values for M1 receptors in rabbit vas deferens. These data suggest that carbachol-induced drinking may be mediated by activation of muscarinic M1 receptors.

PubMedSearch : Polidori_1990_Eur.J.Pharmacol_179_159
PubMedID: 2364977

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Citations formats

Polidori C, Massi M, Lambrecht G, Mutschler E, Tacke R, Melchiorre C (1990)
Selective antagonists provide evidence that M1 muscarinic receptors may mediate carbachol-induced drinking in the rat
European Journal of Pharmacology 179 :159

Polidori C, Massi M, Lambrecht G, Mutschler E, Tacke R, Melchiorre C (1990)
European Journal of Pharmacology 179 :159