| Title : Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease - Prati_2013_Bioorg.Med.Chem.Lett_23_6254 |
| Author(s) : Prati F , Bartolini M , Simoni E , De Simone A , Pinto A , Andrisano V , Bolognesi ML |
| Ref : Bioorganic & Medicinal Chemistry Lett , 23 :6254 , 2013 |
| Abstract : The anti-amyloid properties shared by several quinones inspired the design of a new series of hybrids derived from the multi-target drug candidate memoquin (1). The hybrids consist of a central benzoquinone core and a fragment taken from non-steroidal anti-inflammatory drugs, connected through polyamine linkers. The new hybrids retain the potent anti-aggregating activity of the parent 1, while exhibiting micromolar AChE inhibitory activities. Remarkably, 2, 4, (R)-6 and (S)-6 were Abeta aggregation inhibitors even more potent than 1. The balanced amyloid/cholinesterase inhibitory profile is an added value that makes the present series of compounds promising leads against Alzheimer's disease. |
| ESTHER : Prati_2013_Bioorg.Med.Chem.Lett_23_6254 |
| PubMedSearch : Prati_2013_Bioorg.Med.Chem.Lett_23_6254 |
| PubMedID: 24140444 |
Prati F, Bartolini M, Simoni E, De Simone A, Pinto A, Andrisano V, Bolognesi ML (2013)
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease
Bioorganic & Medicinal Chemistry Lett
23 :6254
Prati F, Bartolini M, Simoni E, De Simone A, Pinto A, Andrisano V, Bolognesi ML (2013)
Bioorganic & Medicinal Chemistry Lett
23 :6254