Bolognesi ML

General

Full name : Bolognesi Maria Laura

First name : Maria Laura

Mail : Department of Pharmacy and Biotechnology, Alma Mater Studiorum, Bologna University, Bologna

Zip Code :

City :

Country : Italy

Email : marialaura.bolognesi@unibo.it

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References (45)

Title : Novel multifunctional tacrine-donepezil hybrids against Alzheimer's disease: Design synthesis and bioactivity studies - Bayraktar_2024_Arch.Pharm.(Weinheim)__e2300575
Author(s) : Bayraktar G , Bartolini M , Bolognesi ML , Erdogan MA , Armagan G , Bayir E , Sendemir A , Bagetta D , Alcaro S , Alptuzun V
Ref : Arch Pharm (Weinheim) , :e2300575 , 2024
PubMedID: 38593283

Title : Quinolinetrione-tacrine hybrids as multi-target-directed ligands against Alzheimer's disease - Uliassi_2023_Bioorg.Med.Chem_91_117419
Author(s) : Uliassi E , Bergamini C , Rizzardi N , Naldi M , Cores A , Bartolini M , Carlos Menendez J , Bolognesi ML
Ref : Bioorganic & Medicinal Chemistry , 91 :117419 , 2023
PubMedID: 37487339

Title : From combinations to multitarget-directed ligands: A continuum in Alzheimer's disease polypharmacology - Albertini_2021_Med.Res.Rev_41_2606
Author(s) : Albertini C , Salerno A , de Sena Murteira Pinheiro P , Bolognesi ML
Ref : Med Res Rev , 41 :2606 , 2021
PubMedID: 32557696

Title : From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects - Pont_2021_Eur.J.Med.Chem_225_113779
Author(s) : Pont C , Ginex T , Grinan-Ferre C , Scheiner M , Mattellone A , Martinez N , Arce EM , Soriano-Fernandez Y , Naldi M , De Simone A , Barenys M , Gomez-Catalan J , Perez B , Sabate R , Andrisano V , Loza MI , Brea J , Bartolini M , Bolognesi ML , Decker M , Pallas M , Luque FJ , Munoz-Torrero D
Ref : Eur Journal of Medicinal Chemistry , 225 :113779 , 2021
PubMedID: 34418785

Title : Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy - Perone_2021_ChemMedChem_16_187
Author(s) : Perone R , Albertini C , Uliassi E , Di Pietri F , de Sena Murteira Pinheiro P , Petralla S , Rizzardi N , Fato R , Pulkrabkova L , Soukup O , Tramarin A , Bartolini M , Bolognesi ML
Ref : ChemMedChem , 16 :187 , 2021
PubMedID: 32716144

Title : Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease - Gorecki_2021_ACS.Chem.Neurosci__
Author(s) : Gorecki L , Uliassi E , Bartolini M , Janockova J , Hrabinova M , Hepnarova V , Prchal L , Muckova L , Pejchal J , Karasova JZ , Mezeiova E , Benkova M , Kobrlova T , Soukup O , Petralla S , Monti B , Korabecny J , Bolognesi ML
Ref : ACS Chem Neurosci , : , 2021
PubMedID: 33852284

Title : Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties - de Andrade Ramos_2021_RSC.Med.Chem_12_1154
Author(s) : de Andrade Ramos G , Souza de Oliveira A , Bartolini M , Naldi M , Liparulo I , Bergamini C , Uliassi E , Wu L , Fraser PE , Abreu M , Kiametis AS , Gargano R , Silveira ER , Brand GD , Prchal L , Soukup O , Korabecny J , Bolognesi ML , Soares Romeiro LA
Ref : RSC Med Chem , 12 :1154 , 2021
PubMedID: 34355181

Title : Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease - Rossi_2021_J.Med.Chem_64_4972
Author(s) : Rossi M , Freschi M , de Camargo Nascente L , Salerno A , de Melo Viana Teixeira S , Nachon F , Chantegreil F , Soukup O , Prchal L , Malaguti M , Bergamini C , Bartolini M , Angeloni C , Hrelia S , Soares Romeiro LA , Bolognesi ML
Ref : Journal of Medicinal Chemistry , 64 :4972 , 2021
PubMedID: 33829779
Gene_locus related to this paper: human-BCHE

Title : N-1,2,3-triazole-isatin derivatives for cholinesterase and beta-amyloid aggregation inhibition: A comprehensive bioassay study - Marques_2020_Bioorg.Chem_98_103753
Author(s) : Marques CS , Lopez O , Bagetta D , Carreiro EP , Petralla S , Bartolini M , Hoffmann M , Alcaro S , Monti B , Bolognesi ML , Decker M , Fernandez-Bolanos JG , Burke AJ
Ref : Bioorg Chem , 98 :103753 , 2020
PubMedID: 32200328

Title : Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease - Chalupova_2019_Eur.J.Med.Chem_168_491
Author(s) : Chalupova K , Korabecny J , Bartolini M , Monti B , Lamba D , Caliandro R , Pesaresi A , Brazzolotto X , Gastellier AJ , Nachon F , Pejchal J , Jarosova M , Hepnarova V , Jun D , Hrabinova M , Dolezal R , Karasova JZ , Mzik M , Kristofikova Z , Misik J , Muckova L , Jost P , Soukup O , Benkova M , Setnicka V , Habartova L , Chvojkova M , Kleteckova L , Vales K , Mezeiova E , Uliassi E , Valis M , Nepovimova E , Bolognesi ML , Kuca K
Ref : Eur Journal of Medicinal Chemistry , 168 :491 , 2019
PubMedID: 30851693
Gene_locus related to this paper: torca-ACHE

Title : Molecular Hybridization as a Tool for Designing Multitarget Drug Candidates for Complex Diseases - Ivasiv_2019_Curr.Top.Med.Chem_19_1694
Author(s) : Ivasiv V , Albertini C , Goncalves AE , Rossi M , Bolognesi ML
Ref : Curr Top Med Chem , 19 :1694 , 2019
PubMedID: 31237210

Title : Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease - Chioua_2018_Eur.J.Med.Chem_155_839
Author(s) : Chioua M , Buzzi E , Moraleda I , Iriepa I , Maj M , Wnorowski A , Giovannini C , Tramarin A , Portali F , Ismaili L , Lopez-Alvarado P , Bolognesi ML , Jozwiak K , Menendez JC , Marco-Contelles J , Bartolini M
Ref : Eur Journal of Medicinal Chemistry , 155 :839 , 2018
PubMedID: 29958119

Title : Neurodegenerative drug discovery: building on the past, looking to the future -
Author(s) : Bolognesi ML
Ref : Future Med Chem , 9 :707 , 2017
PubMedID: 28504913

Title : Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease - Prati_2016_ChemMedChem_11_1284
Author(s) : Prati F , Bergamini C , Fato R , Soukup O , Korabecny J , Andrisano V , Bartolini M , Bolognesi ML
Ref : ChemMedChem , 11 :1284 , 2016
PubMedID: 26880501

Title : Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease - Jerabek_2016_Eur.J.Med.Chem_127_250
Author(s) : Jerabek J , Uliassi E , Guidotti L , Korabecny J , Soukup O , Sepsova V , Hrabinova M , Kuca K , Bartolini M , Pena-Altamira LE , Petralla S , Monti B , Roberti M , Bolognesi ML
Ref : Eur Journal of Medicinal Chemistry , 127 :250 , 2016
PubMedID: 28064079

Title : Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer's Disease - Prati_2016_Molecules_21_
Author(s) : Prati F , Cavalli A , Bolognesi ML
Ref : Molecules , 21 : , 2016
PubMedID: 27070562

Title : Novel tacrine-grafted ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic Acid hybrids - Benchekroun_2015_ChemMedChem_10_523
Author(s) : Benchekroun M , Bartolini M , Egea J , Romero A , Soriano E , Pudlo M , Luzet V , Andrisano V , Jimeno ML , Lopez MG , Wehle S , Gharbi T , Refouvelet B , de Andres L , Herrera-Arozamena C , Monti B , Bolognesi ML , Rodriguez-Franco MI , Decker M , Marco-Contelles J , Ismaili L
Ref : ChemMedChem , 10 :523 , 2015
PubMedID: 25537267

Title : Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease - Lemes_2015_Eur.J.Med.Chem_108_687
Author(s) : Lemes LF , de Andrade Ramos G , de Oliveira AS , da Silva FM , de Castro Couto G , da Silva Boni M , Guimaraes MJ , Souza IN , Bartolini M , Andrisano V , do Nascimento Nogueira PC , Silveira ER , Brand GD , Soukup O , Korabecny J , Romeiro NC , Castro NG , Bolognesi ML , Romeiro LA
Ref : Eur Journal of Medicinal Chemistry , 108 :687 , 2015
PubMedID: 26735910

Title : Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects - Nepovimova_2014_J.Med.Chem_57_8576
Author(s) : Nepovimova E , Uliassi E , Korabecny J , Pena-Altamira LE , Samez S , Pesaresi A , Garcia GE , Bartolini M , Andrisano V , Bergamini C , Fato R , Lamba D , Roberti M , Kuca K , Monti B , Bolognesi ML
Ref : Journal of Medicinal Chemistry , 57 :8576 , 2014
PubMedID: 25259726
Gene_locus related to this paper: torca-ACHE

Title : Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease - Prati_2013_Bioorg.Med.Chem.Lett_23_6254
Author(s) : Prati F , Bartolini M , Simoni E , De Simone A , Pinto A , Andrisano V , Bolognesi ML
Ref : Bioorganic & Medicinal Chemistry Lett , 23 :6254 , 2013
PubMedID: 24140444

Title : Pharmacological characterization of memoquin, a multi-target compound for the treatment of Alzheimer's disease - Capurro_2013_PLoS.One_8_e56870
Author(s) : Capurro V , Busquet P , Lopes JP , Bertorelli R , Tarozzo G , Bolognesi ML , Piomelli D , Reggiani A , Cavalli A
Ref : PLoS ONE , 8 :e56870 , 2013
PubMedID: 23441223

Title : The Bivalent Ligand Approach as a Tool for Improving the in vitro Anti-Alzheimer Multitarget Profile of Dimebon - Rosini_2013_ChemMedChem_8_1276
Author(s) : Rosini M , Simoni E , Bartolini M , Soriano E , Marco-Contelles J , Andrisano V , Monti B , Windisch M , Hutter-Paier B , McClymont DW , Mellor IR , Bolognesi ML
Ref : ChemMedChem , 8 :1276 , 2013
PubMedID: 23824986

Title : Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment - Minarini_2012_Neuropharmacol_62_997
Author(s) : Minarini A , Milelli A , Tumiatti V , Rosini M , Simoni E , Bolognesi ML , Andrisano V , Bartolini M , Motori E , Angeloni C , Hrelia S
Ref : Neuropharmacology , 62 :997 , 2012
PubMedID: 22032870

Title : Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease - Rosini_2011_Eur.J.Med.Chem_46_5435
Author(s) : Rosini M , Simoni E , Bartolini M , Tarozzi A , Matera R , Milelli A , Hrelia P , Andrisano V , Bolognesi ML , Melchiorre C
Ref : Eur Journal of Medicinal Chemistry , 46 :5435 , 2011
PubMedID: 21924801

Title : Tacrine derivatives and Alzheimer's disease - Tumiatti_2010_Curr.Med.Chem_17_1825
Author(s) : Tumiatti V , Minarini A , Bolognesi ML , Milelli A , Rosini M , Melchiorre C
Ref : Curr Med Chem , 17 :1825 , 2010
PubMedID: 20345341

Title : Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action - Bolognesi_2009_Bioorg.Med.Chem.Lett_19_4312
Author(s) : Bolognesi ML , Bartolini M , Rosini M , Andrisano V , Melchiorre C
Ref : Bioorganic & Medicinal Chemistry Lett , 19 :4312 , 2009
PubMedID: 19505825

Title : MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond - Bolognesi_2009_Curr.Pharm.Des_15_601
Author(s) : Bolognesi ML , Rosini M , Andrisano V , Bartolini M , Minarini A , Tumiatti V , Melchiorre C
Ref : Curr Pharm Des , 15 :601 , 2009
PubMedID: 19199985

Title : Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks - Bolognesi_2009_J.Med.Chem_52_7883
Author(s) : Bolognesi ML , Cavalli A , Bergamini C , Fato R , Lenaz G , Rosini M , Bartolini M , Andrisano V , Melchiorre C
Ref : Journal of Medicinal Chemistry , 52 :7883 , 2009
PubMedID: 19813747

Title : From dual binding site acetylcholinesterase inhibitors to multi-target-directed ligands (MTDLs): a step forward in the treatment of Alzheimer's disease - Bolognesi_2008_Mini.Rev.Med.Chem_8_960
Author(s) : Bolognesi ML , Minarini A , Rosini M , Tumiatti V , Melchiorre C
Ref : Mini Rev Med Chem , 8 :960 , 2008
PubMedID: 18782050

Title : Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush - Rosini_2008_J.Med.Chem_51_4381
Author(s) : Rosini M , Simoni E , Bartolini M , Cavalli A , Ceccarini L , Pascu N , McClymont DW , Tarozzi A , Bolognesi ML , Minarini A , Tumiatti V , Andrisano V , Mellor IR , Melchiorre C
Ref : Journal of Medicinal Chemistry , 51 :4381 , 2008
PubMedID: 18605718

Title : Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer - Tumiatti_2008_J.Med.Chem_51_7308
Author(s) : Tumiatti V , Milelli A , Minarini A , Rosini M , Bolognesi ML , Micco M , Andrisano V , Bartolini M , Mancini F , Recanatini M , Cavalli A , Melchiorre C
Ref : Journal of Medicinal Chemistry , 51 :7308 , 2008
PubMedID: 18954037

Title : Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease - Bolognesi_2007_J.Med.Chem_50_6446
Author(s) : Bolognesi ML , Cavalli A , Valgimigli L , Bartolini M , Rosini M , Andrisano V , Recanatini M , Melchiorre C
Ref : Journal of Medicinal Chemistry , 50 :6446 , 2007
PubMedID: 18047264

Title : Rational approach to discover multipotent anti-Alzheimer drugs - Rosini_2005_J.Med.Chem_48_360
Author(s) : Rosini M , Andrisano V , Bartolini M , Bolognesi ML , Hrelia P , Minarini A , Tarozzi A , Melchiorre C
Ref : Journal of Medicinal Chemistry , 48 :360 , 2005
PubMedID: 15658850

Title : Heterocyclic inhibitors of AChE acylation and peripheral sites - Bolognesi_2005_Farmaco_60_465
Author(s) : Bolognesi ML , Andrisano V , Bartolini M , Cavalli A , Minarini A , Recanatini M , Rosini M , Tumiatti V , Melchiorre C
Ref : Farmaco , 60 :465 , 2005
PubMedID: 15878569

Title : Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation - Bolognesi_2005_J.Med.Chem_48_24
Author(s) : Bolognesi ML , Andrisano V , Bartolini M , Banzi R , Melchiorre C
Ref : Journal of Medicinal Chemistry , 48 :24 , 2005
PubMedID: 15633997

Title : Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues - Bolognesi_2004_J.Med.Chem_47_5945
Author(s) : Bolognesi ML , Bartolini M , Cavalli A , Andrisano V , Rosini M , Minarini A , Melchiorre C
Ref : Journal of Medicinal Chemistry , 47 :5945 , 2004
PubMedID: 15537349

Title : Polymethylene tetraamine backbone as template for the development of biologically active polyamines - Melchiorre_2003_Med.Res.Rev_23_200
Author(s) : Melchiorre C , Antonello A , Banzi R , Bolognesi ML , Minarini A , Rosini M , Tumiatti V
Ref : Med Res Rev , 23 :200 , 2003
PubMedID: 12500289

Title : Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure - Bolognesi_2002_J.Med.Chem_45_3286
Author(s) : Bolognesi ML , Bixel MG , Marucci G , Bartolini M , Krauss M , Angeli P , Antonello A , Rosini M , Tumiatti V , Hucho F , Melchiorre C
Ref : Journal of Medicinal Chemistry , 45 :3286 , 2002
PubMedID: 12109912

Title : Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors - Bolognesi_2001_J.Med.Chem_44_105
Author(s) : Bolognesi ML , Andrisano V , Bartolini M , Minarini A , Rosini M , Tumiatti V , Melchiorre C
Ref : Journal of Medicinal Chemistry , 44 :105 , 2001
PubMedID: 11141093

Title : [4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]-trimethylammonium (McN-A-343)-related compounds. Effect of the butynyl chain inclusion into an aromatic unit on the potency for muscarinic receptors - Tumiatti_2000_Bioorg.Med.Chem_8_681
Author(s) : Tumiatti V , Angeli P , Andrisano V , Bolognesi ML , Cavalli A , Marucci G , Minarini A , Recanatini M , Rosini M , Melchiorre C
Ref : Bioorganic & Medicinal Chemistry , 8 :681 , 2000
PubMedID: 10819156

Title : Prejunctional muscarinic inhibitory control of acetylcholine release in the human isolated detrusor: involvement of the M4 receptor subtype - D'Agostino_2000_Br.J.Pharmacol_129_493
Author(s) : D'Agostino G , Bolognesi ML , Lucchelli A , Vicini D , Balestra B , Spelta V , Melchiorre C , Tonini M
Ref : British Journal of Pharmacology , 129 :493 , 2000
PubMedID: 10711347

Title : Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists - Rosini_1999_J.Med.Chem_42_5212
Author(s) : Rosini M , Budriesi R , Bixel MG , Bolognesi ML , Chiarini A , Hucho F , Krogsgaard-Larsen P , Mellor IR , Minarini A , Tumiatti V , Usherwood PN , Melchiorre C
Ref : Journal of Medicinal Chemistry , 42 :5212 , 1999
PubMedID: 10602706

Title : Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone for Potential Use against Alzheimer's Disease -
Author(s) : Melchiorre C , Andrisano V , Bolognesi ML , Budriesi R , Cavalli A , Cavrini V , Rosini M , Tumiatti V , Recanatini M
Ref : Journal of Medicinal Chemistry , 41 :4186 , 1998
PubMedID: 9784091

Title : Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists - Bolognesi_1998_J.Med.Chem_41_4150
Author(s) : Bolognesi ML , Minarini A , Budriesi R , Cacciaguerra S , Chiarini A , Spampinato S , Tumiatti V , Melchiorre C
Ref : Journal of Medicinal Chemistry , 41 :4150 , 1998
PubMedID: 9767650

Title : Binding profile of benextramine at neuropeptide Y receptor subtypes in rat brain areas - Melchiorre_1994_Eur.J.Pharmacol_265_93
Author(s) : Melchiorre C , Romualdi P , Bolognesi ML , Donatini A , Ferri S
Ref : European Journal of Pharmacology , 265 :93 , 1994
PubMedID: 7883034