Full name : Bartolini Manuela
First name : Manuela
Mail : University of Bologna\; Department of Pharmaceutical Sciences\; via Belmeloro 6\; 40126 Bologna
Zip Code :
City :
Country : Italy
Email : manuela.bartolini3@unibo.it
Phone : +390512099729
Fax :
Website :
Directory :
Comment
| Title : Novel multifunctional tacrine-donepezil hybrids against Alzheimer's disease: Design synthesis and bioactivity studies - Bayraktar_2024_Arch.Pharm.(Weinheim)__e2300575 |
| Author(s) : Bayraktar G , Bartolini M , Bolognesi ML , Erdogan MA , Armagan G , Bayir E , Sendemir A , Bagetta D , Alcaro S , Alptuzun V |
| Ref : Arch Pharm (Weinheim) , :e2300575 , 2024 |
| Abstract : |
| PubMedSearch : Bayraktar_2024_Arch.Pharm.(Weinheim)__e2300575 |
| PubMedID: 38593283 |
| Title : Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties - Pont_2024_Pharmaceutics_16_ |
| Author(s) : Pont C , Sampietro A , Perez-Areales FJ , Cristiano N , Albalat A , Perez B , Bartolini M , De Simone A , Andrisano V , Barenys M , Teixido E , Sabate R , Loza MI , Brea J , Munoz-Torrero D |
| Ref : Pharmaceutics , 16 : , 2024 |
| Abstract : |
| PubMedSearch : Pont_2024_Pharmaceutics_16_ |
| PubMedID: 39204327 |
| Title : Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties - Basagni_2023_Eur.J.Med.Chem_261_115803 |
| Author(s) : Basagni F , Ortega JA , Bertozzi SM , Armirotti A , Summa M , Bertorelli R , Bartolini M , Mellor IR , Bedeschi M , Bottegoni G , Lembo V , Minarini A , Cavalli A , Rosini M |
| Ref : Eur Journal of Medicinal Chemistry , 261 :115803 , 2023 |
| Abstract : |
| PubMedSearch : Basagni_2023_Eur.J.Med.Chem_261_115803 |
| PubMedID: 37734258 |
| Title : Quinolinetrione-tacrine hybrids as multi-target-directed ligands against Alzheimer's disease - Uliassi_2023_Bioorg.Med.Chem_91_117419 |
| Author(s) : Uliassi E , Bergamini C , Rizzardi N , Naldi M , Cores A , Bartolini M , Carlos Menendez J , Bolognesi ML |
| Ref : Bioorganic & Medicinal Chemistry , 91 :117419 , 2023 |
| Abstract : |
| PubMedSearch : Uliassi_2023_Bioorg.Med.Chem_91_117419 |
| PubMedID: 37487339 |
| Title : Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease - Codony_2022_J.Med.Chem_65_4909 |
| Author(s) : Codony S , Pont C , Grinan-Ferre C , Di Pede-Mattatelli A , Calvo-Tusell C , Feixas F , Osuna S , Jarne-Ferrer J , Naldi M , Bartolini M , Loza MI , Brea J , Perez B , Bartra C , Sanfeliu C , Juarez-Jimenez J , Morisseau C , Hammock BD , Pallas M , Vazquez S , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 65 :4909 , 2022 |
| Abstract : |
| PubMedSearch : Codony_2022_J.Med.Chem_65_4909 |
| PubMedID: 35271276 |
| Title : (+\/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease - Ismaili_2021_ACS.Chem.Neurosci__ |
| Author(s) : Ismaili L , Monnin J , Etievant A , Arribas RL , Viejo L , Refouvelet B , Soukup O , Janockova J , Hepnarova V , Korabecny J , Kucera T , Jun D , Andrys R , Musilek K , Baguet A , Garcia-Frutos EM , De Simone A , Andrisano V , Bartolini M , de los Rios C , Marco-Contelles J , Haffen E |
| Ref : ACS Chem Neurosci , : , 2021 |
| Abstract : |
| PubMedSearch : Ismaili_2021_ACS.Chem.Neurosci__ |
| PubMedID: 33797877 |
| Title : New Coumarin Derivatives as Cholinergic and Cannabinoid System Modulators - Montanari_2021_Molecules_26_3254 |
| Author(s) : Montanari S , Allara M , Scalvini L , Kostrzewa M , Belluti F , Gobbi S , Naldi M , Rivara S , Bartolini M , Ligresti A , Bisi A , Rampa A |
| Ref : Molecules , 26 :3254 , 2021 |
| Abstract : |
| PubMedSearch : Montanari_2021_Molecules_26_3254 |
| PubMedID: 34071439 |
| Title : Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties - de Andrade Ramos_2021_RSC.Med.Chem_12_1154 |
| Author(s) : de Andrade Ramos G , Souza de Oliveira A , Bartolini M , Naldi M , Liparulo I , Bergamini C , Uliassi E , Wu L , Fraser PE , Abreu M , Kiametis AS , Gargano R , Silveira ER , Brand GD , Prchal L , Soukup O , Korabecny J , Bolognesi ML , Soares Romeiro LA |
| Ref : RSC Med Chem , 12 :1154 , 2021 |
| Abstract : |
| PubMedSearch : de Andrade Ramos_2021_RSC.Med.Chem_12_1154 |
| PubMedID: 34355181 |
| Title : Bio-Guided Fractionation of Stem Bark Extracts from Phyllanthus muellarianus: Identification of Phytocomponents with Anti-Cholinesterase Activity - Naldi_2021_Molecules_26_ |
| Author(s) : Naldi M , Brusotti G , Massolini G , Andrisano V , Temporini C , Bartolini M |
| Ref : Molecules , 26 : , 2021 |
| Abstract : |
| PubMedSearch : Naldi_2021_Molecules_26_ |
| PubMedID: 34299650 |
| Title : From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects - Pont_2021_Eur.J.Med.Chem_225_113779 |
| Author(s) : Pont C , Ginex T , Grinan-Ferre C , Scheiner M , Mattellone A , Martinez N , Arce EM , Soriano-Fernandez Y , Naldi M , De Simone A , Barenys M , Gomez-Catalan J , Perez B , Sabate R , Andrisano V , Loza MI , Brea J , Bartolini M , Bolognesi ML , Decker M , Pallas M , Luque FJ , Munoz-Torrero D |
| Ref : Eur Journal of Medicinal Chemistry , 225 :113779 , 2021 |
| Abstract : |
| PubMedSearch : Pont_2021_Eur.J.Med.Chem_225_113779 |
| PubMedID: 34418785 |
| Title : Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP\/PS1 Mice - Viayna_2021_J.Med.Chem_64_812 |
| Author(s) : Viayna E , Coquelle N , Cieslikiewicz-Bouet M , Cisternas P , Oliva CA , Sanchez-Lopez E , Ettcheto M , Bartolini M , De Simone A , Ricchini M , Rendina M , Pons M , Firuzi O , Perez B , Saso L , Andrisano V , Nachon F , Brazzolotto X , Garcia ML , Camins A , Silman I , Jean L , Inestrosa NC , Colletier JP , Renard PY , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 64 :812 , 2021 |
| Abstract : |
| PubMedSearch : Viayna_2021_J.Med.Chem_64_812 |
| PubMedID: 33356266 |
| Gene_locus related to this paper: human-ACHE |
| Title : Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy - Perone_2021_ChemMedChem_16_187 |
| Author(s) : Perone R , Albertini C , Uliassi E , Di Pietri F , de Sena Murteira Pinheiro P , Petralla S , Rizzardi N , Fato R , Pulkrabkova L , Soukup O , Tramarin A , Bartolini M , Bolognesi ML |
| Ref : ChemMedChem , 16 :187 , 2021 |
| Abstract : |
| PubMedSearch : Perone_2021_ChemMedChem_16_187 |
| PubMedID: 32716144 |
| Title : Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease - Rossi_2021_J.Med.Chem_64_4972 |
| Author(s) : Rossi M , Freschi M , de Camargo Nascente L , Salerno A , de Melo Viana Teixeira S , Nachon F , Chantegreil F , Soukup O , Prchal L , Malaguti M , Bergamini C , Bartolini M , Angeloni C , Hrelia S , Soares Romeiro LA , Bolognesi ML |
| Ref : Journal of Medicinal Chemistry , 64 :4972 , 2021 |
| Abstract : |
| PubMedSearch : Rossi_2021_J.Med.Chem_64_4972 |
| PubMedID: 33829779 |
| Gene_locus related to this paper: human-BCHE |
| Title : Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease - Gorecki_2021_ACS.Chem.Neurosci__ |
| Author(s) : Gorecki L , Uliassi E , Bartolini M , Janockova J , Hrabinova M , Hepnarova V , Prchal L , Muckova L , Pejchal J , Karasova JZ , Mezeiova E , Benkova M , Kobrlova T , Soukup O , Petralla S , Monti B , Korabecny J , Bolognesi ML |
| Ref : ACS Chem Neurosci , : , 2021 |
| Abstract : |
| PubMedSearch : Gorecki_2021_ACS.Chem.Neurosci__ |
| PubMedID: 33852284 |
| Title : N-1,2,3-triazole-isatin derivatives for cholinesterase and beta-amyloid aggregation inhibition: A comprehensive bioassay study - Marques_2020_Bioorg.Chem_98_103753 |
| Author(s) : Marques CS , Lopez O , Bagetta D , Carreiro EP , Petralla S , Bartolini M , Hoffmann M , Alcaro S , Monti B , Bolognesi ML , Decker M , Fernandez-Bolanos JG , Burke AJ |
| Ref : Bioorg Chem , 98 :103753 , 2020 |
| Abstract : |
| PubMedSearch : Marques_2020_Bioorg.Chem_98_103753 |
| PubMedID: 32200328 |
| Title : Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6 - Perez-Areales_2020_J.Med.Chem_63_9360 |
| Author(s) : Perez-Areales FJ , Garrido M , Aso E , Bartolini M , De Simone A , Espargaro A , Ginex T , Sabate R , Perez B , Andrisano V , Puigoriol-Illamola D , Pallas M , Luque FJ , Loza MI , Brea J , Ferrer I , Ciruela F , Messeguer A , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 63 :9360 , 2020 |
| Abstract : |
| PubMedSearch : Perez-Areales_2020_J.Med.Chem_63_9360 |
| PubMedID: 32706255 |
| Title : Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor - Cieslikiewicz-Bouet_2020_Biochem.Pharmacol__114010 |
| Author(s) : Cieslikiewicz-Bouet M , Naldi M , Bartolini M , Perez B , Servent D , Jean L , Araoz R , Renard PY |
| Ref : Biochemical Pharmacology , :114010 , 2020 |
| Abstract : |
| PubMedSearch : Cieslikiewicz-Bouet_2020_Biochem.Pharmacol__114010 |
| PubMedID: 32360492 |
| Title : Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment - Montanari_2019_Eur.J.Med.Chem_178_243 |
| Author(s) : Montanari S , Mahmoud AM , Pruccoli L , Rabbito A , Naldi M , Petralla S , Moraleda I , Bartolini M , Monti B , Iriepa I , Belluti F , Gobbi S , Di Marzo V , Bisi A , Tarozzi A , Ligresti A , Rampa A |
| Ref : Eur Journal of Medicinal Chemistry , 178 :243 , 2019 |
| Abstract : |
| PubMedSearch : Montanari_2019_Eur.J.Med.Chem_178_243 |
| PubMedID: 31185414 |
| Title : Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo - Scheiner_2019_J.Med.Chem_62_9078 |
| Author(s) : Scheiner M , Dolles D , Gunesch S , Hoffmann M , Nabissi M , Marinelli O , Naldi M , Bartolini M , Petralla S , Poeta E , Monti B , Falkeis C , Vieth M , Hubner H , Gmeiner P , Maitra R , Maurice T , Decker M |
| Ref : Journal of Medicinal Chemistry , 62 :9078 , 2019 |
| Abstract : |
| PubMedSearch : Scheiner_2019_J.Med.Chem_62_9078 |
| PubMedID: 31609608 |
| Title : A novel class of multitarget anti-Alzheimer benzohomoadamantanechlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors - Perez-Areales_2019_Eur.J.Med.Chem_180_613 |
| Author(s) : Perez-Areales FJ , Turcu AL , Barniol-Xicota M , Pont C , Pivetta D , Espargaro A , Bartolini M , De Simone A , Andrisano V , Perez B , Sabate R , Sureda FX , Vazquez S , Munoz-Torrero D |
| Ref : Eur Journal of Medicinal Chemistry , 180 :613 , 2019 |
| Abstract : |
| PubMedSearch : Perez-Areales_2019_Eur.J.Med.Chem_180_613 |
| PubMedID: 31351393 |
| Title : Advanced analytical methodologies in Alzheimer's disease drug discovery - De Simone_2019_J.Pharm.Biomed.Anal_178_112899 |
| Author(s) : De Simone A , Naldi M , Tedesco D , Bartolini M , Davani L , Andrisano V |
| Ref : J Pharm Biomed Anal , 178 :112899 , 2019 |
| Abstract : |
| PubMedSearch : De Simone_2019_J.Pharm.Biomed.Anal_178_112899 |
| PubMedID: 31606562 |
| Title : Tacrines as Therapeutic Agents for Alzheimer's Disease. IV. The Tacripyrines and Related Annulated Tacrines - Bartolini_2019_Chem.Rec_19_927 |
| Author(s) : Bartolini M , Marco-Contelles J |
| Ref : Chem Rec , 19 :927 , 2019 |
| Abstract : |
| PubMedSearch : Bartolini_2019_Chem.Rec_19_927 |
| PubMedID: 30489012 |
| Title : Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase - AlFadly_2019_Eur.J.Med.Chem_167_161 |
| Author(s) : AlFadly ED , Elzahhar PA , Tramarin A , Elkazaz S , Shaltout H , Abu-Serie MM , Janockova J , Soukup O , Ghareeb DA , El-Yazbi AF , Rafeh RW , Bakkar NZ , Kobeissy F , Iriepa I , Moraleda I , Saudi MNS , Bartolini M , Belal ASF |
| Ref : Eur Journal of Medicinal Chemistry , 167 :161 , 2019 |
| Abstract : |
| PubMedSearch : AlFadly_2019_Eur.J.Med.Chem_167_161 |
| PubMedID: 30771604 |
| Title : Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease - Chalupova_2019_Eur.J.Med.Chem_168_491 |
| Author(s) : Chalupova K , Korabecny J , Bartolini M , Monti B , Lamba D , Caliandro R , Pesaresi A , Brazzolotto X , Gastellier AJ , Nachon F , Pejchal J , Jarosova M , Hepnarova V , Jun D , Hrabinova M , Dolezal R , Karasova JZ , Mzik M , Kristofikova Z , Misik J , Muckova L , Jost P , Soukup O , Benkova M , Setnicka V , Habartova L , Chvojkova M , Kleteckova L , Vales K , Mezeiova E , Uliassi E , Valis M , Nepovimova E , Bolognesi ML , Kuca K |
| Ref : Eur Journal of Medicinal Chemistry , 168 :491 , 2019 |
| Abstract : |
| PubMedSearch : Chalupova_2019_Eur.J.Med.Chem_168_491 |
| PubMedID: 30851693 |
| Gene_locus related to this paper: torca-ACHE |
| Title : QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy - Ramos_2019_Molecules_24_ |
| Author(s) : Ramos E , Palomino-Antolin A , Bartolini M , Iriepa I , Moraleda I , Diez-Iriepa D , Samadi A , Cortina CV , Chioua M , Egea J , Romero A , Marco-Contelles J |
| Ref : Molecules , 24 : , 2019 |
| Abstract : |
| PubMedSearch : Ramos_2019_Molecules_24_ |
| PubMedID: 30999586 |
| Title : Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 - Oukoloff_2019_Eur.J.Med.Chem_168_58 |
| Author(s) : Oukoloff K , Coquelle N , Bartolini M , Naldi M , Le Guevel R , Bach S , Josselin B , Ruchaud S , Catto M , Pisani L , Denora N , Iacobazzi RM , Silman I , Sussman JL , Buron F , Colletier JP , Jean L , Routier S , Renard PY |
| Ref : Eur Journal of Medicinal Chemistry , 168 :58 , 2019 |
| Abstract : |
| PubMedSearch : Oukoloff_2019_Eur.J.Med.Chem_168_58 |
| PubMedID: 30798053 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening - Fabini_2018_J.Pharm.Biomed.Anal_155_177 |
| Author(s) : Fabini E , Tramarin A , Bartolini M |
| Ref : J Pharm Biomed Anal , 155 :177 , 2018 |
| Abstract : |
| PubMedSearch : Fabini_2018_J.Pharm.Biomed.Anal_155_177 |
| PubMedID: 29635172 |
| Title : A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017 - Andrisano_2018_Expert.Opin.Ther.Pat_28_455 |
| Author(s) : Andrisano V , Naldi M , De Simone A , Bartolini M |
| Ref : Expert Opin Ther Pat , 28 :455 , 2018 |
| Abstract : |
| PubMedSearch : Andrisano_2018_Expert.Opin.Ther.Pat_28_455 |
| PubMedID: 29757691 |
| Title : Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis - Galdeano_2018_Molecules_23_ |
| Author(s) : Galdeano C , Coquelle N , Cieslikiewicz-Bouet M , Bartolini M , Perez B , Clos MV , Silman I , Jean L , Colletier JP , Renard PY , Munoz-Torrero D |
| Ref : Molecules , 23 : , 2018 |
| Abstract : |
| PubMedSearch : Galdeano_2018_Molecules_23_ |
| PubMedID: 29534488 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease - Chioua_2018_Eur.J.Med.Chem_155_839 |
| Author(s) : Chioua M , Buzzi E , Moraleda I , Iriepa I , Maj M , Wnorowski A , Giovannini C , Tramarin A , Portali F , Ismaili L , Lopez-Alvarado P , Bolognesi ML , Jozwiak K , Menendez JC , Marco-Contelles J , Bartolini M |
| Ref : Eur Journal of Medicinal Chemistry , 155 :839 , 2018 |
| Abstract : |
| PubMedSearch : Chioua_2018_Eur.J.Med.Chem_155_839 |
| PubMedID: 29958119 |
| Title : Exploiting the Chalcone Scaffold to Develop Multifunctional Agents for Alzheimer's Disease - Rampa_2018_Molecules_23_ |
| Author(s) : Rampa A , Bartolini M , Pruccoli L , Naldi M , Iriepa I , Moraleda I , Belluti F , Gobbi S , Tarozzi A , Bisi A |
| Ref : Molecules , 23 : , 2018 |
| Abstract : |
| PubMedSearch : Rampa_2018_Molecules_23_ |
| PubMedID: 30061534 |
| Title : New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation - Pandolfi_2017_Eur.J.Med.Chem_141_197 |
| Author(s) : Pandolfi F , De Vita D , Bortolami M , Coluccia A , Di Santo R , Costi R , Andrisano V , Alabiso F , Bergamini C , Fato R , Bartolini M , Scipione L |
| Ref : Eur Journal of Medicinal Chemistry , 141 :197 , 2017 |
| Abstract : |
| PubMedSearch : Pandolfi_2017_Eur.J.Med.Chem_141_197 |
| PubMedID: 29031067 |
| Title : Uleine Disrupts Key Enzymatic and Non-Enzymatic Biomarkers that Leads to Alzheimer's Disease - Seidl_2017_Curr.Alzheimer.Res_14_317 |
| Author(s) : Seidl C , de Moraes Santos CA , De Simone A , Bartolini M , Weffort-Santos AM , Andrisano V |
| Ref : Curr Alzheimer Res , 14 :317 , 2017 |
| Abstract : |
| PubMedSearch : Seidl_2017_Curr.Alzheimer.Res_14_317 |
| PubMedID: 27784218 |
| Title : Chalcone-based carbamates for Alzheimer's disease treatment - Rampa_2017_Future.Med.Chem_9_749 |
| Author(s) : Rampa A , Montanari S , Pruccoli L , Bartolini M , Falchi F , Feoli A , Cavalli A , Belluti F , Gobbi S , Tarozzi A , Bisi A |
| Ref : Future Med Chem , 9 :749 , 2017 |
| Abstract : |
| PubMedSearch : Rampa_2017_Future.Med.Chem_9_749 |
| PubMedID: 28498775 |
| Title : Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids - Perez-Areales_2017_Future.Med.Chem_9_965 |
| Author(s) : Perez-Areales FJ , Betari N , Viayna A , Pont C , Espargaro A , Bartolini M , De Simone A , Rinaldi Alvarenga JF , Perez B , Sabate R , Lamuela-Raventos RM , Andrisano V , Luque FJ , Munoz-Torrero D |
| Ref : Future Med Chem , 9 :965 , 2017 |
| Abstract : |
| PubMedSearch : Perez-Areales_2017_Future.Med.Chem_9_965 |
| PubMedID: 28632395 |
| Title : Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-beta aggregation - Simoni_2017_Future.Med.Chem_9_953 |
| Author(s) : Simoni E , Bartolini M , Abu IF , Blockley A , Gotti C , Bottegoni G , Caporaso R , Bergamini C , Andrisano V , Cavalli A , Mellor IR , Minarini A , Rosini M |
| Ref : Future Med Chem , 9 :953 , 2017 |
| Abstract : |
| PubMedSearch : Simoni_2017_Future.Med.Chem_9_953 |
| PubMedID: 28632446 |
| Title : Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease - Prati_2016_ChemMedChem_11_1284 |
| Author(s) : Prati F , Bergamini C , Fato R , Soukup O , Korabecny J , Andrisano V , Bartolini M , Bolognesi ML |
| Ref : ChemMedChem , 11 :1284 , 2016 |
| Abstract : |
| PubMedSearch : Prati_2016_ChemMedChem_11_1284 |
| PubMedID: 26880501 |
| Title : Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease - Jerabek_2016_Eur.J.Med.Chem_127_250 |
| Author(s) : Jerabek J , Uliassi E , Guidotti L , Korabecny J , Soukup O , Sepsova V , Hrabinova M , Kuca K , Bartolini M , Pena-Altamira LE , Petralla S , Monti B , Roberti M , Bolognesi ML |
| Ref : Eur Journal of Medicinal Chemistry , 127 :250 , 2016 |
| Abstract : |
| PubMedSearch : Jerabek_2016_Eur.J.Med.Chem_127_250 |
| PubMedID: 28064079 |
| Title : Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives - Montanari_2016_ChemMedChem_11_1296 |
| Author(s) : Montanari S , Bartolini M , Neviani P , Belluti F , Gobbi S , Pruccoli L , Tarozzi A , Falchi F , Andrisano V , Miszta P , Cavalli A , Filipek S , Bisi A , Rampa A |
| Ref : ChemMedChem , 11 :1296 , 2016 |
| Abstract : |
| PubMedSearch : Montanari_2016_ChemMedChem_11_1296 |
| PubMedID: 26507467 |
| Title : Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents - Montanari_2016_J.Med.Chem_59_6387 |
| Author(s) : Montanari S , Scalvini L , Bartolini M , Belluti F , Gobbi S , Andrisano V , Ligresti A , Di Marzo V , Rivara S , Mor M , Bisi A , Rampa A |
| Ref : Journal of Medicinal Chemistry , 59 :6387 , 2016 |
| Abstract : |
| PubMedSearch : Montanari_2016_J.Med.Chem_59_6387 |
| PubMedID: 27309570 |
| Title : Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer's Disease Therapy - Boulebd_2016_Molecules_21_ |
| Author(s) : Boulebd H , Ismaili L , Bartolini M , Bouraiou A , Andrisano V , Martin H , Bonet A , Moraleda I , Iriepa I , Chioua M , Belfaitah A , Marco-Contelles J |
| Ref : Molecules , 21 : , 2016 |
| Abstract : |
| PubMedSearch : Boulebd_2016_Molecules_21_ |
| PubMedID: 27023499 |
| Title : Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography - Zha_2016_J.Med.Chem_59_114 |
| Author(s) : Zha X , Lamba D , Zhang L , Lou Y , Xu C , Kang D , Chen L , Xu Y , De Simone A , Samez S , Pesaresi A , Stojan J , Lopez MG , Egea J , Andrisano V , Bartolini M |
| Ref : Journal of Medicinal Chemistry , 59 :114 , 2016 |
| Abstract : |
| PubMedSearch : Zha_2016_J.Med.Chem_59_114 |
| PubMedID: 26632651 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease - Lemes_2015_Eur.J.Med.Chem_108_687 |
| Author(s) : Lemes LF , de Andrade Ramos G , de Oliveira AS , da Silva FM , de Castro Couto G , da Silva Boni M , Guimaraes MJ , Souza IN , Bartolini M , Andrisano V , do Nascimento Nogueira PC , Silveira ER , Brand GD , Soukup O , Korabecny J , Romeiro NC , Castro NG , Bolognesi ML , Romeiro LA |
| Ref : Eur Journal of Medicinal Chemistry , 108 :687 , 2015 |
| Abstract : |
| PubMedSearch : Lemes_2015_Eur.J.Med.Chem_108_687 |
| PubMedID: 26735910 |
| Title : Poster: Multi-target directed ligands: Electrophysiological characterization of an anticholinesterase inhibitor coupled to an agonist of alpha7 nicotinic acetylcholine receptor - |
| Author(s) : Araoz R , Bouet m , Bartolini M , Coquelle N , Colletier JP , Servent D , Molgo J , Jean L , Renard PY |
| Ref : Biochemical Pharmacology , 97 :621 , 2015 |
| PubMedID: |
| Title : Novel tacrine-grafted ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic Acid hybrids - Benchekroun_2015_ChemMedChem_10_523 |
| Author(s) : Benchekroun M , Bartolini M , Egea J , Romero A , Soriano E , Pudlo M , Luzet V , Andrisano V , Jimeno ML , Lopez MG , Wehle S , Gharbi T , Refouvelet B , de Andres L , Herrera-Arozamena C , Monti B , Bolognesi ML , Rodriguez-Franco MI , Decker M , Marco-Contelles J , Ismaili L |
| Ref : ChemMedChem , 10 :523 , 2015 |
| Abstract : |
| PubMedSearch : Benchekroun_2015_ChemMedChem_10_523 |
| PubMedID: 25537267 |
| Title : Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents - Viayna_2014_J.Med.Chem_57_2549 |
| Author(s) : Viayna E , Sola I , Bartolini M , De Simone A , Tapia-Rojas C , Serrano FG , Sabate R , Juarez-Jimenez J , Perez B , Luque FJ , Andrisano V , Clos MV , Inestrosa NC , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 57 :2549 , 2014 |
| Abstract : |
| PubMedSearch : Viayna_2014_J.Med.Chem_57_2549 |
| PubMedID: 24568372 |
| Title : From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer's disease - Tarozzi_2014_Pharmacol.Res.Perspect_2_e00023 |
| Author(s) : Tarozzi A , Bartolini M , Piazzi L , Valgimigli L , Amorati R , Bolondi C , Djemil A , Mancini F , Andrisano V , Rampa A |
| Ref : Pharmacol Res Perspect , 2 :e00023 , 2014 |
| Abstract : |
| PubMedSearch : Tarozzi_2014_Pharmacol.Res.Perspect_2_e00023 |
| PubMedID: 25505579 |
| Title : Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease - Belluti_2014_Eur.J.Med.Chem_78C_157 |
| Author(s) : Belluti F , De Simone A , Tarozzi A , Bartolini M , Djemil A , Bisi A , Gobbi S , Montanari S , Cavalli A , Andrisano V , Bottegoni G , Rampa A |
| Ref : Eur Journal of Medicinal Chemistry , 78C :157 , 2014 |
| Abstract : |
| PubMedSearch : Belluti_2014_Eur.J.Med.Chem_78C_157 |
| PubMedID: 24681980 |
| Title : Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects - Nepovimova_2014_J.Med.Chem_57_8576 |
| Author(s) : Nepovimova E , Uliassi E , Korabecny J , Pena-Altamira LE , Samez S , Pesaresi A , Garcia GE , Bartolini M , Andrisano V , Bergamini C , Fato R , Lamba D , Roberti M , Kuca K , Monti B , Bolognesi ML |
| Ref : Journal of Medicinal Chemistry , 57 :8576 , 2014 |
| Abstract : |
| PubMedSearch : Nepovimova_2014_J.Med.Chem_57_8576 |
| PubMedID: 25259726 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Disease-Modifying Anti-Alzheimer's Drugs: Inhibitors of Human Cholinesterases Interfering with beta-Amyloid Aggregation - Brogi_2014_CNS.Neurosci.Ther_20_624 |
| Author(s) : Brogi S , Butini S , Maramai S , Colombo R , Verga L , Lanni C , De Lorenzi E , Lamponi S , Andreassi M , Bartolini M , Andrisano V , Novellino E , Campiani G , Brindisi M , Gemma S |
| Ref : CNS Neurosci Ther , 20 :624 , 2014 |
| Abstract : |
| PubMedSearch : Brogi_2014_CNS.Neurosci.Ther_20_624 |
| PubMedID: 24935788 |
| Title : 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies - Di Pietro_2013_Eur.J.Med.Chem_73C_141 |
| Author(s) : Di Pietro O , Viayna E , Vicente-Garcia E , Bartolini M , Ramon R , Juarez-Jimenez J , Clos MV , Perez B , Andrisano V , Luque FJ , Lavilla R , Munoz-Torrero D |
| Ref : Eur Journal of Medicinal Chemistry , 73C :141 , 2013 |
| Abstract : |
| PubMedSearch : Di Pietro_2013_Eur.J.Med.Chem_73C_141 |
| PubMedID: 24389509 |
| Title : Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase - Bartolini_2013_Anal.Bioanal.Chem_405_795 |
| Author(s) : Bartolini M , Naldi M , Nicolau DV , van Delft FC , van Zijl J , Snijder J , van den Heuvel EF , Naburgh EP , Calonghi N , Andrisano V |
| Ref : Anal Bioanal Chem , 405 :795 , 2013 |
| Abstract : |
| PubMedSearch : Bartolini_2013_Anal.Bioanal.Chem_405_795 |
| PubMedID: 22814970 |
| Title : Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease - Prati_2013_Bioorg.Med.Chem.Lett_23_6254 |
| Author(s) : Prati F , Bartolini M , Simoni E , De Simone A , Pinto A , Andrisano V , Bolognesi ML |
| Ref : Bioorganic & Medicinal Chemistry Lett , 23 :6254 , 2013 |
| Abstract : |
| PubMedSearch : Prati_2013_Bioorg.Med.Chem.Lett_23_6254 |
| PubMedID: 24140444 |
| Title : Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation - Butini_2013_ACS.Med.Chem.Lett_4_1178 |
| Author(s) : Butini S , Brindisi M , Brogi S , Maramai S , Guarino E , Panico A , Saxena A , Chauhan V , Colombo R , Verga L , De Lorenzi E , Bartolini M , Andrisano V , Novellino E , Campiani G , Gemma S |
| Ref : ACS Med Chem Lett , 4 :1178 , 2013 |
| Abstract : |
| PubMedSearch : Butini_2013_ACS.Med.Chem.Lett_4_1178 |
| PubMedID: 24900626 |
| Title : The Bivalent Ligand Approach as a Tool for Improving the in vitro Anti-Alzheimer Multitarget Profile of Dimebon - Rosini_2013_ChemMedChem_8_1276 |
| Author(s) : Rosini M , Simoni E , Bartolini M , Soriano E , Marco-Contelles J , Andrisano V , Monti B , Windisch M , Hutter-Paier B , McClymont DW , Mellor IR , Bolognesi ML |
| Ref : ChemMedChem , 8 :1276 , 2013 |
| Abstract : |
| PubMedSearch : Rosini_2013_ChemMedChem_8_1276 |
| PubMedID: 23824986 |
| Title : Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine - Samadi_2012_Eur.J.Med.Chem_52_251 |
| Author(s) : Samadi A , de los Rios C , Bolea I , Chioua M , Iriepa I , Moraleda I , Bartolini M , Andrisano V , Galvez E , Valderas C , Unzeta M , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 52 :251 , 2012 |
| Abstract : |
| PubMedSearch : Samadi_2012_Eur.J.Med.Chem_52_251 |
| PubMedID: 22503231 |
| Title : Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment - Minarini_2012_Neuropharmacol_62_997 |
| Author(s) : Minarini A , Milelli A , Tumiatti V , Rosini M , Simoni E , Bolognesi ML , Andrisano V , Bartolini M , Motori E , Angeloni C , Hrelia S |
| Ref : Neuropharmacology , 62 :997 , 2012 |
| Abstract : |
| PubMedSearch : Minarini_2012_Neuropharmacol_62_997 |
| PubMedID: 22032870 |
| Title : The First Dual ChE\/FAAH Inhibitors: New Perspectives for Alzheimer's Disease? - Rampa_2012_ACS.Med.Chem.Lett_3_182 |
| Author(s) : Rampa A , Bartolini M , Bisi A , Belluti F , Gobbi S , Andrisano V , Ligresti A , Di Marzo V |
| Ref : ACS Med Chem Lett , 3 :182 , 2012 |
| Abstract : |
| PubMedSearch : Rampa_2012_ACS.Med.Chem.Lett_3_182 |
| PubMedID: 24900454 |
| Title : Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases - Galdeano_2012_J.Med.Chem_55_661 |
| Author(s) : Galdeano C , Viayna E , Sola I , Formosa X , Camps P , Badia A , Clos MV , Relat J , Ratia M , Bartolini M , Mancini F , Andrisano V , Salmona M , Minguillon C , Gonzalez-Munoz GC , Rodriguez-Franco MI , Bidon-Chanal A , Luque FJ , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 55 :661 , 2012 |
| Abstract : |
| PubMedSearch : Galdeano_2012_J.Med.Chem_55_661 |
| PubMedID: 22185619 |
| Title : Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers - Rizzo_2011_Eur.J.Med.Chem_46_4336 |
| Author(s) : Rizzo S , Bisi A , Bartolini M , Mancini F , Belluti F , Gobbi S , Andrisano V , Rampa A |
| Ref : Eur Journal of Medicinal Chemistry , 46 :4336 , 2011 |
| Abstract : |
| PubMedSearch : Rizzo_2011_Eur.J.Med.Chem_46_4336 |
| PubMedID: 21798635 |
| Title : Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease - Rosini_2011_Eur.J.Med.Chem_46_5435 |
| Author(s) : Rosini M , Simoni E , Bartolini M , Tarozzi A , Matera R , Milelli A , Hrelia P , Andrisano V , Bolognesi ML , Melchiorre C |
| Ref : Eur Journal of Medicinal Chemistry , 46 :5435 , 2011 |
| Abstract : |
| PubMedSearch : Rosini_2011_Eur.J.Med.Chem_46_5435 |
| PubMedID: 21924801 |
| Title : Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation - Belluti_2011_Eur.J.Med.Chem_46_1682 |
| Author(s) : Belluti F , Bartolini M , Bottegoni G , Bisi A , Cavalli A , Andrisano V , Rampa A |
| Ref : Eur Journal of Medicinal Chemistry , 46 :1682 , 2011 |
| Abstract : |
| PubMedSearch : Belluti_2011_Eur.J.Med.Chem_46_1682 |
| PubMedID: 21397996 |
| Title : Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues - Martins_2011_Eur.J.Med.Chem_46_6119 |
| Author(s) : Martins C , Carreiras MC , Leon R , de los Rios C , Bartolini M , Andrisano V , Iriepa I , Moraleda I , Galvez E , Garcia M , Egea J , Samadi A , Chioua M , Marco-Contelles J |
| Ref : Eur Journal of Medicinal Chemistry , 46 :6119 , 2011 |
| Abstract : |
| PubMedSearch : Martins_2011_Eur.J.Med.Chem_46_6119 |
| PubMedID: 22000936 |
| Title : Novel huprine derivatives with inhibitory activity toward beta-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates - Viayna_2010_ChemMedChem_5_1855 |
| Author(s) : Viayna E , Gomez T , Galdeano C , Ramirez L , Ratia M , Badia A , Clos MV , Verdaguer E , Junyent F , Camins A , Pallas M , Bartolini M , Mancini F , Andrisano V , Arce MP , Rodriguez-Franco MI , Bidon-Chanal A , Luque FJ , Camps P , Munoz-Torrero D |
| Ref : ChemMedChem , 5 :1855 , 2010 |
| Abstract : |
| PubMedSearch : Viayna_2010_ChemMedChem_5_1855 |
| PubMedID: 20859987 |
| Title : Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238 - Rizzo_2010_Bioorg.Med.Chem_18_1749 |
| Author(s) : Rizzo S , Bartolini M , Ceccarini L , Piazzi L , Gobbi S , Cavalli A , Recanatini M , Andrisano V , Rampa A |
| Ref : Bioorganic & Medicinal Chemistry , 18 :1749 , 2010 |
| Abstract : |
| PubMedSearch : Rizzo_2010_Bioorg.Med.Chem_18_1749 |
| PubMedID: 20171894 |
| Title : Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates - Camps_2010_Chem.Biol.Interact_187_411 |
| Author(s) : Camps P , Formosa X , Galdeano C , Gomez T , Munoz-Torrero D , Ramirez L , Viayna E , Gomez E , Isambert N , Lavilla R , Badia A , Clos MV , Bartolini M , Mancini F , Andrisano V , Bidon-Chanal A , Huertas O , Dafni T , Luque FJ |
| Ref : Chemico-Biological Interactions , 187 :411 , 2010 |
| Abstract : |
| PubMedSearch : Camps_2010_Chem.Biol.Interact_187_411 |
| PubMedID: 20167211 |
| Title : Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action - Bolognesi_2009_Bioorg.Med.Chem.Lett_19_4312 |
| Author(s) : Bolognesi ML , Bartolini M , Rosini M , Andrisano V , Melchiorre C |
| Ref : Bioorganic & Medicinal Chemistry Lett , 19 :4312 , 2009 |
| Abstract : |
| PubMedSearch : Bolognesi_2009_Bioorg.Med.Chem.Lett_19_4312 |
| PubMedID: 19505825 |
| Title : MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond - Bolognesi_2009_Curr.Pharm.Des_15_601 |
| Author(s) : Bolognesi ML , Rosini M , Andrisano V , Bartolini M , Minarini A , Tumiatti V , Melchiorre C |
| Ref : Curr Pharm Des , 15 :601 , 2009 |
| Abstract : |
| PubMedSearch : Bolognesi_2009_Curr.Pharm.Des_15_601 |
| PubMedID: 19199985 |
| Title : Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks - Bolognesi_2009_J.Med.Chem_52_7883 |
| Author(s) : Bolognesi ML , Cavalli A , Bergamini C , Fato R , Lenaz G , Rosini M , Bartolini M , Andrisano V , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 52 :7883 , 2009 |
| Abstract : |
| PubMedSearch : Bolognesi_2009_J.Med.Chem_52_7883 |
| PubMedID: 19813747 |
| Title : Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors - Belluti_2009_Eur.J.Med.Chem_44_1341 |
| Author(s) : Belluti F , Piazzi L , Bisi A , Gobbi S , Bartolini M , Cavalli A , Valenti P , Rampa A |
| Ref : Eur Journal of Medicinal Chemistry , 44 :1341 , 2009 |
| Abstract : |
| PubMedSearch : Belluti_2009_Eur.J.Med.Chem_44_1341 |
| PubMedID: 18396354 |
| Title : Structure-activity relationships and binding mode in the human acetylcholinesterase active site of pseudo-irreversible inhibitors related to xanthostigmine - Rizzo_2009_ChemMedChem_4_670 |
| Author(s) : Rizzo S , Cavalli A , Ceccarini L , Bartolini M , Belluti F , Bisi A , Andrisano V , Recanatini M , Rampa A |
| Ref : ChemMedChem , 4 :670 , 2009 |
| Abstract : |
| PubMedSearch : Rizzo_2009_ChemMedChem_4_670 |
| PubMedID: 19222043 |
| Title : Immobilized butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer's disease - Bartolini_2009_J.Chromatogr.A_1216_2730 |
| Author(s) : Bartolini M , Greig NH , Yu QS , Andrisano V |
| Ref : Journal of Chromatography A , 1216 :2730 , 2009 |
| Abstract : |
| PubMedSearch : Bartolini_2009_J.Chromatogr.A_1216_2730 |
| PubMedID: 18950780 |
| Title : Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds - Camps_2009_J.Med.Chem_52_5365 |
| Author(s) : Camps P , Formosa X , Galdeano C , Munoz-Torrero D , Ramirez L , Gomez E , Isambert N , Lavilla R , Badia A , Clos MV , Bartolini M , Mancini F , Andrisano V , Arce MP , Rodriguez-Franco MI , Huertas O , Dafni T , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 52 :5365 , 2009 |
| Abstract : |
| PubMedSearch : Camps_2009_J.Med.Chem_52_5365 |
| PubMedID: 19663388 |
| Title : Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer - Tumiatti_2008_J.Med.Chem_51_7308 |
| Author(s) : Tumiatti V , Milelli A , Minarini A , Rosini M , Bolognesi ML , Micco M , Andrisano V , Bartolini M , Mancini F , Recanatini M , Cavalli A , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 51 :7308 , 2008 |
| Abstract : |
| PubMedSearch : Tumiatti_2008_J.Med.Chem_51_7308 |
| PubMedID: 18954037 |
| Title : The role of Li+, Na+, and K+ in the ligand binding inside the human acetylcholinesterase gorge - Petraglio_2008_Proteins_70_779 |
| Author(s) : Petraglio G , Bartolini M , Branduardi D , Andrisano V , Recanatini M , Gervasio FL , Cavalli A , Parrinello M |
| Ref : Proteins , 70 :779 , 2008 |
| Abstract : |
| PubMedSearch : Petraglio_2008_Proteins_70_779 |
| PubMedID: 17729290 |
| Title : Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds - Piazzi_2008_Bioorg.Med.Chem.Lett_18_423 |
| Author(s) : Piazzi L , Cavalli A , Colizzi F , Belluti F , Bartolini M , Mancini F , Recanatini M , Andrisano V , Rampa A |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :423 , 2008 |
| Abstract : |
| PubMedSearch : Piazzi_2008_Bioorg.Med.Chem.Lett_18_423 |
| PubMedID: 17998161 |
| Title : Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush - Rosini_2008_J.Med.Chem_51_4381 |
| Author(s) : Rosini M , Simoni E , Bartolini M , Cavalli A , Ceccarini L , Pascu N , McClymont DW , Tarozzi A , Bolognesi ML , Minarini A , Tumiatti V , Andrisano V , Mellor IR , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 51 :4381 , 2008 |
| Abstract : |
| PubMedSearch : Rosini_2008_J.Med.Chem_51_4381 |
| PubMedID: 18605718 |
| Title : Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation - Camps_2008_J.Med.Chem_51_3588 |
| Author(s) : Camps P , Formosa X , Galdeano C , Gomez T , Munoz-Torrero D , Scarpellini M , Viayna E , Badia A , Clos MV , Camins A , Pallas M , Bartolini M , Mancini F , Andrisano V , Estelrich J , Lizondo M , Bidon-Chanal A , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 51 :3588 , 2008 |
| Abstract : |
| PubMedSearch : Camps_2008_J.Med.Chem_51_3588 |
| PubMedID: 18517184 |
| Title : Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity - Rizzo_2008_J.Med.Chem_51_2883 |
| Author(s) : Rizzo S , Riviere C , Piazzi L , Bisi A , Gobbi S , Bartolini M , Andrisano V , Morroni F , Tarozzi A , Monti JP , Rampa A |
| Ref : Journal of Medicinal Chemistry , 51 :2883 , 2008 |
| Abstract : |
| PubMedSearch : Rizzo_2008_J.Med.Chem_51_2883 |
| PubMedID: 18419109 |
| Title : Lipid peroxidation in stroke patients - Ferretti_2008_Clin.Chem.Lab.Med_46_113 |
| Author(s) : Ferretti G , Bacchetti T , Masciangelo S , Nanetti L , Mazzanti L , Silvestrini M , Bartolini M , Provinciali L |
| Ref : Clinical Chemistry & Laboratory Medicine , 46 :113 , 2008 |
| Abstract : |
| PubMedSearch : Ferretti_2008_Clin.Chem.Lab.Med_46_113 |
| PubMedID: 18034641 |
| Title : Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease - Bolognesi_2007_J.Med.Chem_50_6446 |
| Author(s) : Bolognesi ML , Cavalli A , Valgimigli L , Bartolini M , Rosini M , Andrisano V , Recanatini M , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 50 :6446 , 2007 |
| Abstract : |
| PubMedSearch : Bolognesi_2007_J.Med.Chem_50_6446 |
| PubMedID: 18047264 |
| Title : Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives - Piazzi_2007_J.Med.Chem_50_4250 |
| Author(s) : Piazzi L , Cavalli A , Belluti F , Bisi A , Gobbi S , Rizzo S , Bartolini M , Andrisano V , Recanatini M , Rampa A |
| Ref : Journal of Medicinal Chemistry , 50 :4250 , 2007 |
| Abstract : |
| PubMedSearch : Piazzi_2007_J.Med.Chem_50_4250 |
| PubMedID: 17655212 |
| Title : Characterization of reversible and pseudo-irreversible acetylcholinesterase inhibitors by means of an immobilized enzyme reactor - Bartolini_2007_J.Chromatogr.A_1144_102 |
| Author(s) : Bartolini M , Cavrini V , Andrisano V |
| Ref : Journal of Chromatography A , 1144 :102 , 2007 |
| Abstract : |
| PubMedSearch : Bartolini_2007_J.Chromatogr.A_1144_102 |
| PubMedID: 17134713 |
| Title : Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones - Piazzi_2007_Bioorg.Med.Chem_15_575 |
| Author(s) : Piazzi L , Belluti F , Bisi A , Gobbi S , Rizzo S , Bartolini M , Andrisano V , Recanatini M , Rampa A |
| Ref : Bioorganic & Medicinal Chemistry , 15 :575 , 2007 |
| Abstract : |
| PubMedSearch : Piazzi_2007_Bioorg.Med.Chem_15_575 |
| PubMedID: 17008100 |
| Title : Analysis of Amaryllidaceae alkaloids from Narcissus by GC-MS and capillary electrophoresis - Gotti_2006_J.Pharm.Biomed.Anal_42_17 |
| Author(s) : Gotti R , Fiori J , Bartolini M , Cavrini V |
| Ref : J Pharm Biomed Anal , 42 :17 , 2006 |
| Abstract : |
| PubMedSearch : Gotti_2006_J.Pharm.Biomed.Anal_42_17 |
| PubMedID: 16460902 |
| Title : Batchwise covalent immobilization of human acetylcholinesterase: Kinetic and inhibition spectrophotometric studies - |
| Author(s) : Bartolini M , Cavrini V , Andrisano V |
| Ref : Analytical Biochemistry , 342 :163 , 2005 |
| PubMedID: 15958194 |
| Title : Heterocyclic inhibitors of AChE acylation and peripheral sites - Bolognesi_2005_Farmaco_60_465 |
| Author(s) : Bolognesi ML , Andrisano V , Bartolini M , Cavalli A , Minarini A , Recanatini M , Rosini M , Tumiatti V , Melchiorre C |
| Ref : Farmaco , 60 :465 , 2005 |
| Abstract : |
| PubMedSearch : Bolognesi_2005_Farmaco_60_465 |
| PubMedID: 15878569 |
| Title : Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease - Munoz-Ruiz_2005_J.Med.Chem_48_7223 |
| Author(s) : Munoz-Ruiz P , Rubio L , Garcia-Palomero E , Dorronsoro I , del Monte-Millan M , Valenzuela R , Usan P , de Austria C , Bartolini M , Andrisano V , Bidon-Chanal A , Orozco M , Luque FJ , Medina M , Martinez A |
| Ref : Journal of Medicinal Chemistry , 48 :7223 , 2005 |
| Abstract : |
| PubMedSearch : Munoz-Ruiz_2005_J.Med.Chem_48_7223 |
| PubMedID: 16279781 |
| Title : Rational approach to discover multipotent anti-Alzheimer drugs - Rosini_2005_J.Med.Chem_48_360 |
| Author(s) : Rosini M , Andrisano V , Bartolini M , Bolognesi ML , Hrelia P , Minarini A , Tarozzi A , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 48 :360 , 2005 |
| Abstract : |
| PubMedSearch : Rosini_2005_J.Med.Chem_48_360 |
| PubMedID: 15658850 |
| Title : Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation - Bolognesi_2005_J.Med.Chem_48_24 |
| Author(s) : Bolognesi ML , Andrisano V , Bartolini M , Banzi R , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 48 :24 , 2005 |
| Abstract : |
| PubMedSearch : Bolognesi_2005_J.Med.Chem_48_24 |
| PubMedID: 15633997 |
| Title : Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation - Belluti_2005_J.Med.Chem_48_4444 |
| Author(s) : Belluti F , Rampa A , Piazzi L , Bisi A , Gobbi S , Bartolini M , Andrisano V , Cavalli A , Recanatini M , Valenti P |
| Ref : Journal of Medicinal Chemistry , 48 :4444 , 2005 |
| Abstract : |
| PubMedSearch : Belluti_2005_J.Med.Chem_48_4444 |
| PubMedID: 15974596 |
| Title : Choosing the right chromatographic support in making a new acetylcholinesterase-micro-immobilised enzyme reactor for drug discovery - Bartolini_2005_J.Chromatogr.A_1065_135 |
| Author(s) : Bartolini M , Cavrini V , Andrisano V |
| Ref : Journal of Chromatography A , 1065 :135 , 2005 |
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| PubMedSearch : Bartolini_2005_J.Chromatogr.A_1065_135 |
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| Title : Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues - Bolognesi_2004_J.Med.Chem_47_5945 |
| Author(s) : Bolognesi ML , Bartolini M , Cavalli A , Andrisano V , Rosini M , Minarini A , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 47 :5945 , 2004 |
| Abstract : |
| PubMedSearch : Bolognesi_2004_J.Med.Chem_47_5945 |
| PubMedID: 15537349 |
| Title : Monolithic micro-immobilized-enzyme reactor with human recombinant acetylcholinesterase for on-line inhibition studies - Bartolini_2004_J.Chromatogr.A_1031_27 |
| Author(s) : Bartolini M , Cavrini V , Andrisano V |
| Ref : Journal of Chromatography A , 1031 :27 , 2004 |
| Abstract : |
| PubMedSearch : Bartolini_2004_J.Chromatogr.A_1031_27 |
| PubMedID: 15058565 |
| Title : Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties - Tumiatti_2004_J.Med.Chem_47_6490 |
| Author(s) : Tumiatti V , Andrisano V , Banzi R , Bartolini M , Minarini A , Rosini M , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 47 :6490 , 2004 |
| Abstract : |
| PubMedSearch : Tumiatti_2004_J.Med.Chem_47_6490 |
| PubMedID: 15588084 |
| Title : Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine - Tumiatti_2003_J.Med.Chem_46_954 |
| Author(s) : Tumiatti V , Rosini M , Bartolini M , Cavalli A , Marucci G , Andrisano V , Angeli P , Banzi R , Minarini A , Recanatini M , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 46 :954 , 2003 |
| Abstract : |
| PubMedSearch : Tumiatti_2003_J.Med.Chem_46_954 |
| PubMedID: 12620072 |
| Title : 3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy - Piazzi_2003_J.Med.Chem_46_2279 |
| Author(s) : Piazzi L , Rampa A , Bisi A , Gobbi S , Belluti F , Cavalli A , Bartolini M , Andrisano V , Valenti P , Recanatini M |
| Ref : Journal of Medicinal Chemistry , 46 :2279 , 2003 |
| Abstract : |
| PubMedSearch : Piazzi_2003_J.Med.Chem_46_2279 |
| PubMedID: 12773032 |
| Title : beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies - Bartolini_2003_Biochem.Pharmacol_65_407 |
| Author(s) : Bartolini M , Bertucci C , Cavrini V , Andrisano V |
| Ref : Biochemical Pharmacology , 65 :407 , 2003 |
| Abstract : |
| PubMedSearch : Bartolini_2003_Biochem.Pharmacol_65_407 |
| PubMedID: 12527333 |
| Title : Determination of the dissociation constants (pKa) of basic acetylcholinesterase inhibitors by reversed-phase liquid chromatography - Bartolini_2002_J.Chromatogr.A_958_59 |
| Author(s) : Bartolini M , Bertucci C , Gotti R , Tumiatti V , Cavalli A , Recanatini M , Andrisano V |
| Ref : Journal of Chromatography A , 958 :59 , 2002 |
| Abstract : |
| PubMedSearch : Bartolini_2002_J.Chromatogr.A_958_59 |
| PubMedID: 12134831 |
| Title : Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure - Bolognesi_2002_J.Med.Chem_45_3286 |
| Author(s) : Bolognesi ML , Bixel MG , Marucci G , Bartolini M , Krauss M , Angeli P , Antonello A , Rosini M , Tumiatti V , Hucho F , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 45 :3286 , 2002 |
| Abstract : |
| PubMedSearch : Bolognesi_2002_J.Med.Chem_45_3286 |
| PubMedID: 12109912 |
| Title : Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors - Bolognesi_2001_J.Med.Chem_44_105 |
| Author(s) : Bolognesi ML , Andrisano V , Bartolini M , Minarini A , Rosini M , Tumiatti V , Melchiorre C |
| Ref : Journal of Medicinal Chemistry , 44 :105 , 2001 |
| Abstract : |
| PubMedSearch : Bolognesi_2001_J.Med.Chem_44_105 |
| PubMedID: 11141093 |
| Title : Determination of inhibitors' potency (IC50) by a direct high-performance liquid chromatographic method on an immobilised acetylcholinesterase column - Andrisano_2001_J.Chromatogr.B.Biomed.Sci.Appl_753_375 |
| Author(s) : Andrisano V , Bartolini M , Gotti R , Cavrini V , Felix G |
| Ref : Journal of Chromatography B Biomed Sci Appl , 753 :375 , 2001 |
| Abstract : |
| PubMedSearch : Andrisano_2001_J.Chromatogr.B.Biomed.Sci.Appl_753_375 |
| PubMedID: 11334353 |
| Title : Acetylcholinesterase Inhibitors: SAR and Kinetic Studies on omega-[N-Methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl Derivatives - Rampa_2001_J.Med.Chem_44_3810 |
| Author(s) : Rampa A , Piazzi L , Belluti F , Gobbi S , Bisi A , Bartolini M , Andrisano V , Cavrini V , Cavalli A , Recanatini M , Valenti P |
| Ref : Journal of Medicinal Chemistry , 44 :3810 , 2001 |
| Abstract : |
| PubMedSearch : Rampa_2001_J.Med.Chem_44_3810 |
| PubMedID: 11689067 |
| Title : SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues - Recanatini_2000_J.Med.Chem_43_2007 |
| Author(s) : Recanatini M , Cavalli A , Belluti F , Piazzi L , Rampa A , Bisi A , Gobbi S , Valenti P , Andrisano V , Bartolini M , Cavrini V |
| Ref : Journal of Medicinal Chemistry , 43 :2007 , 2000 |
| Abstract : |
| PubMedSearch : Recanatini_2000_J.Med.Chem_43_2007 |
| PubMedID: 10821713 |