| Title : Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties - Pont_2024_Pharmaceutics_16_ |
| Author(s) : Pont C , Sampietro A , Perez-Areales FJ , Cristiano N , Albalat A , Perez B , Bartolini M , De Simone A , Andrisano V , Barenys M , Teixido E , Sabate R , Loza MI , Brea J , Munoz-Torrero D |
| Ref : Pharmaceutics , 16 : , 2024 |
| Abstract : |
| PubMedSearch : Pont_2024_Pharmaceutics_16_ |
| PubMedID: 39204327 |
| Title : Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease - Fernandes_2022_J.Ethnopharmacol_290_115107 |
| Author(s) : Fernandes F , Barroso MF , De Simone A , Emrikova E , Dias-Teixeira M , Pereira JP , Chlebek J , Fernandes VC , Rodrigues F , Andrisano V , Delerue-Matos C , Grosso C |
| Ref : J Ethnopharmacol , 290 :115107 , 2022 |
| Abstract : |
| PubMedSearch : Fernandes_2022_J.Ethnopharmacol_290_115107 |
| PubMedID: 35176467 |
| Title : From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects - Pont_2021_Eur.J.Med.Chem_225_113779 |
| Author(s) : Pont C , Ginex T , Grinan-Ferre C , Scheiner M , Mattellone A , Martinez N , Arce EM , Soriano-Fernandez Y , Naldi M , De Simone A , Barenys M , Gomez-Catalan J , Perez B , Sabate R , Andrisano V , Loza MI , Brea J , Bartolini M , Bolognesi ML , Decker M , Pallas M , Luque FJ , Munoz-Torrero D |
| Ref : Eur Journal of Medicinal Chemistry , 225 :113779 , 2021 |
| Abstract : |
| PubMedSearch : Pont_2021_Eur.J.Med.Chem_225_113779 |
| PubMedID: 34418785 |
| Title : Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP\/PS1 Mice - Viayna_2021_J.Med.Chem_64_812 |
| Author(s) : Viayna E , Coquelle N , Cieslikiewicz-Bouet M , Cisternas P , Oliva CA , Sanchez-Lopez E , Ettcheto M , Bartolini M , De Simone A , Ricchini M , Rendina M , Pons M , Firuzi O , Perez B , Saso L , Andrisano V , Nachon F , Brazzolotto X , Garcia ML , Camins A , Silman I , Jean L , Inestrosa NC , Colletier JP , Renard PY , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 64 :812 , 2021 |
| Abstract : |
| PubMedSearch : Viayna_2021_J.Med.Chem_64_812 |
| PubMedID: 33356266 |
| Gene_locus related to this paper: human-ACHE |
| Title : (+\/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease - Ismaili_2021_ACS.Chem.Neurosci__ |
| Author(s) : Ismaili L , Monnin J , Etievant A , Arribas RL , Viejo L , Refouvelet B , Soukup O , Janockova J , Hepnarova V , Korabecny J , Kucera T , Jun D , Andrys R , Musilek K , Baguet A , Garcia-Frutos EM , De Simone A , Andrisano V , Bartolini M , de los Rios C , Marco-Contelles J , Haffen E |
| Ref : ACS Chem Neurosci , : , 2021 |
| Abstract : |
| PubMedSearch : Ismaili_2021_ACS.Chem.Neurosci__ |
| PubMedID: 33797877 |
| Title : Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6 - Perez-Areales_2020_J.Med.Chem_63_9360 |
| Author(s) : Perez-Areales FJ , Garrido M , Aso E , Bartolini M , De Simone A , Espargaro A , Ginex T , Sabate R , Perez B , Andrisano V , Puigoriol-Illamola D , Pallas M , Luque FJ , Loza MI , Brea J , Ferrer I , Ciruela F , Messeguer A , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 63 :9360 , 2020 |
| Abstract : |
| PubMedSearch : Perez-Areales_2020_J.Med.Chem_63_9360 |
| PubMedID: 32706255 |
| Title : Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer's disease - Perinova_2020_Bioorg.Chem_100_103928 |
| Author(s) : Perinova R , Maafi N , Korabecny J , Kohelova E , De Simone A , Al Mamun A , Hulcova D , Markova J , Kucera T , Jun D , Safratova M , Marikova J , Andrisano V , Jenco J , Kunes J , Martinez A , Novakova L , Cahlikova L |
| Ref : Bioorg Chem , 100 :103928 , 2020 |
| Abstract : |
| PubMedSearch : Perinova_2020_Bioorg.Chem_100_103928 |
| PubMedID: 32450384 |
| Title : Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease - Hulcova_2019_Phytochemistry_165_112055 |
| Author(s) : Hulcova D , Marikova J , Korabecny J , Hostalkova A , Jun D , Kunes J , Chlebek J , Opletal L , De Simone A , Novakova L , Andrisano V , Ruzicka A , Cahlikova L |
| Ref : Phytochemistry , 165 :112055 , 2019 |
| Abstract : |
| PubMedSearch : Hulcova_2019_Phytochemistry_165_112055 |
| PubMedID: 31261031 |
| Title : A novel class of multitarget anti-Alzheimer benzohomoadamantanechlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors - Perez-Areales_2019_Eur.J.Med.Chem_180_613 |
| Author(s) : Perez-Areales FJ , Turcu AL , Barniol-Xicota M , Pont C , Pivetta D , Espargaro A , Bartolini M , De Simone A , Andrisano V , Perez B , Sabate R , Sureda FX , Vazquez S , Munoz-Torrero D |
| Ref : Eur Journal of Medicinal Chemistry , 180 :613 , 2019 |
| Abstract : |
| PubMedSearch : Perez-Areales_2019_Eur.J.Med.Chem_180_613 |
| PubMedID: 31351393 |
| Title : Advanced analytical methodologies in Alzheimer's disease drug discovery - De Simone_2019_J.Pharm.Biomed.Anal_178_112899 |
| Author(s) : De Simone A , Naldi M , Tedesco D , Bartolini M , Davani L , Andrisano V |
| Ref : J Pharm Biomed Anal , 178 :112899 , 2019 |
| Abstract : |
| PubMedSearch : De Simone_2019_J.Pharm.Biomed.Anal_178_112899 |
| PubMedID: 31606562 |
| Title : Derivatives of the beta-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer's Disease - Kohelova_2019_Molecules_24_ |
| Author(s) : Kohelova E , Perinova R , Maafi N , Korabecny J , Hulcova D , Marikova J , Kucera T , Martinez Gonzalez L , Hrabinova M , Vorcakova K , Novakova L , De Simone A , Havelek R , Cahlikova L |
| Ref : Molecules , 24 : , 2019 |
| Abstract : |
| PubMedSearch : Kohelova_2019_Molecules_24_ |
| PubMedID: 30987121 |
| Title : A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017 - Andrisano_2018_Expert.Opin.Ther.Pat_28_455 |
| Author(s) : Andrisano V , Naldi M , De Simone A , Bartolini M |
| Ref : Expert Opin Ther Pat , 28 :455 , 2018 |
| Abstract : |
| PubMedSearch : Andrisano_2018_Expert.Opin.Ther.Pat_28_455 |
| PubMedID: 29757691 |
| Title : Uleine Disrupts Key Enzymatic and Non-Enzymatic Biomarkers that Leads to Alzheimer's Disease - Seidl_2017_Curr.Alzheimer.Res_14_317 |
| Author(s) : Seidl C , de Moraes Santos CA , De Simone A , Bartolini M , Weffort-Santos AM , Andrisano V |
| Ref : Curr Alzheimer Res , 14 :317 , 2017 |
| Abstract : |
| PubMedSearch : Seidl_2017_Curr.Alzheimer.Res_14_317 |
| PubMedID: 27784218 |
| Title : Tacrine-based Multifunctional Agents in Alzheimer's Disease: An Old Story in Continuous Development section sign - Milelli_2017_Curr.Med.Chem_24_3522 |
| Author(s) : Milelli A , De Simone A , Ticchi N , Chen HH , Betari N , Andrisano V , Tumiatti V |
| Ref : Curr Med Chem , 24 :3522 , 2017 |
| Abstract : |
| PubMedSearch : Milelli_2017_Curr.Med.Chem_24_3522 |
| PubMedID: 28294041 |
| Title : Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids - Perez-Areales_2017_Future.Med.Chem_9_965 |
| Author(s) : Perez-Areales FJ , Betari N , Viayna A , Pont C , Espargaro A , Bartolini M , De Simone A , Rinaldi Alvarenga JF , Perez B , Sabate R , Lamuela-Raventos RM , Andrisano V , Luque FJ , Munoz-Torrero D |
| Ref : Future Med Chem , 9 :965 , 2017 |
| Abstract : |
| PubMedSearch : Perez-Areales_2017_Future.Med.Chem_9_965 |
| PubMedID: 28632395 |
| Title : Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography - Zha_2016_J.Med.Chem_59_114 |
| Author(s) : Zha X , Lamba D , Zhang L , Lou Y , Xu C , Kang D , Chen L , Xu Y , De Simone A , Samez S , Pesaresi A , Stojan J , Lopez MG , Egea J , Andrisano V , Bartolini M |
| Ref : Journal of Medicinal Chemistry , 59 :114 , 2016 |
| Abstract : |
| PubMedSearch : Zha_2016_J.Med.Chem_59_114 |
| PubMedID: 26632651 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets - Chlebek_2016_Fitoterapia_109_241 |
| Author(s) : Chlebek J , De Simone A , Hostalkova A , Opletal L , Perez C , Perez DI , Havlikova L , Cahlikova L , Andrisano V |
| Ref : Fitoterapia , 109 :241 , 2016 |
| Abstract : |
| PubMedSearch : Chlebek_2016_Fitoterapia_109_241 |
| PubMedID: 26779945 |
| Title : From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold - Rampa_2015_Bioorg.Med.Chem.Lett_25_2804 |
| Author(s) : Rampa A , Mancini F , De Simone A , Falchi F , Belluti F , Di Martino RM , Gobbi S , Andrisano V , Tarozzi A , Bartolini M , Cavalli A , Bisi A |
| Ref : Bioorganic & Medicinal Chemistry Lett , 25 :2804 , 2015 |
| Abstract : |
| PubMedSearch : Rampa_2015_Bioorg.Med.Chem.Lett_25_2804 |
| PubMedID: 26003339 |
| Title : Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease - Belluti_2014_Eur.J.Med.Chem_78C_157 |
| Author(s) : Belluti F , De Simone A , Tarozzi A , Bartolini M , Djemil A , Bisi A , Gobbi S , Montanari S , Cavalli A , Andrisano V , Bottegoni G , Rampa A |
| Ref : Eur Journal of Medicinal Chemistry , 78C :157 , 2014 |
| Abstract : |
| PubMedSearch : Belluti_2014_Eur.J.Med.Chem_78C_157 |
| PubMedID: 24681980 |
| Title : Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents - Viayna_2014_J.Med.Chem_57_2549 |
| Author(s) : Viayna E , Sola I , Bartolini M , De Simone A , Tapia-Rojas C , Serrano FG , Sabate R , Juarez-Jimenez J , Perez B , Luque FJ , Andrisano V , Clos MV , Inestrosa NC , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 57 :2549 , 2014 |
| Abstract : |
| PubMedSearch : Viayna_2014_J.Med.Chem_57_2549 |
| PubMedID: 24568372 |
| Title : Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease - Prati_2013_Bioorg.Med.Chem.Lett_23_6254 |
| Author(s) : Prati F , Bartolini M , Simoni E , De Simone A , Pinto A , Andrisano V , Bolognesi ML |
| Ref : Bioorganic & Medicinal Chemistry Lett , 23 :6254 , 2013 |
| Abstract : |
| PubMedSearch : Prati_2013_Bioorg.Med.Chem.Lett_23_6254 |
| PubMedID: 24140444 |
| Title : Reversible human serum albumin binding of lipocrine: a circular dichroism study - Bertucci_2011_Chirality_23_827 |
| Author(s) : Bertucci C , De Simone A , Pistolozzi M , Rosini M |
| Ref : Chirality , 23 :827 , 2011 |
| Abstract : |
| PubMedSearch : Bertucci_2011_Chirality_23_827 |
| PubMedID: 21919078 |