| Title : Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M - Rusch_2011_Angew.Chem.Int.Ed.Engl_50_9838 |
| Author(s) : Rusch M , Zimmermann TJ , Burger M , Dekker FJ , Gormer K , Triola G , Brockmeyer A , Janning P , Bottcher T , Sieber SA , Vetter IR , Hedberg C , Waldmann H |
| Ref : Angew Chem Int Ed Engl , 50 :9838 , 2011 |
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Abstract :
Finding the target: activity-based proteomic profiling probes based on the depalmitoylation inhibitors palmostatin B and M have been synthesized and were found to target acyl protein thioesterase 1 (APT1) and 2 (APT2) in cells. |
| PubMedSearch : Rusch_2011_Angew.Chem.Int.Ed.Engl_50_9838 |
| PubMedID: 21905186 |
| Gene_locus related to this paper: human-LYPLA1 , human-LYPLA2 |
| Inhibitor | Palmostatin-M Palmostatin-B |
| Gene_locus | human-LYPLA1 human-LYPLA2 |
Rusch M, Zimmermann TJ, Burger M, Dekker FJ, Gormer K, Triola G, Brockmeyer A, Janning P, Bottcher T, Sieber SA, Vetter IR, Hedberg C, Waldmann H (2011)
Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M
Angew Chem Int Ed Engl
50 :9838
Rusch M, Zimmermann TJ, Burger M, Dekker FJ, Gormer K, Triola G, Brockmeyer A, Janning P, Bottcher T, Sieber SA, Vetter IR, Hedberg C, Waldmann H (2011)
Angew Chem Int Ed Engl
50 :9838