human-LYPLA2
Homo sapiens (Human) acyl-protein thioesterase dJ886K2.4 lysophospholipase II APT2
Comment
another gene human-apthio2 DJ570F3.6 OldTrembl Q9UGE0 Ncbi_pid 6624592 ENSG00000206168 situated very close is a processed pseudo gene
Relationship
Family : LYsophospholipase_carboxylesterase
Block : X
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMolecular evidence
No mutation
No kinetic
No disease
Database
Sequence
Peptide
MCGNTMSVPL LTDAATVSGA ERETAAVIFL HGLGDTGHSW ADALSTIRLP HVKYICPHAP RIPVTLNMKM VMPSWFDLMG LSPDAPEDEA GIKKAAENIK ALIEHEMKNG IPANRIVLGG FSQGGALSLY TALTCPHPLA GIVALSCWLP LHRAFPQAAN GSAKDLAILQ CHGELDPMVP VRFGALTAEK LRSVVTPARV QFKTYPGVMH SSCPQEMAAV KEFLEKLLPP V
References (11)
| Title : Nanobody-thioesterase chimeras to specifically target protein palmitoylation - Kuo_2025_Nat.Commun_16_1445 |
| Author(s) : Kuo CW , Gok C , Fulton H , Dickson-Murray E , Adu S , Gallen EK , Mary S , Robertson AD , Jordan F , Dunning E , Mullen W , Smith GL , Fuller W |
| Ref : Nat Commun , 16 :1445 , 2025 |
| Abstract : |
| PubMedSearch : Kuo_2025_Nat.Commun_16_1445 |
| PubMedID: 39920166 |
| Gene_locus related to this paper: human-LYPLA1 , human-LYPLA2 |
| Title : Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria - Speck_2023_Cell.Rep_42_113389 |
| Author(s) : Speck SL , Bhatt DP , Zhang Q , Adak S , Yin L , Dong G , Feng C , Zhang W , Ben Major M , Wei X , Semenkovich CF |
| Ref : Cell Rep , 42 :113389 , 2023 |
| Abstract : |
| PubMedSearch : Speck_2023_Cell.Rep_42_113389 |
| PubMedID: 37925639 |
| Gene_locus related to this paper: human-LYPLA1 , human-LYPLA2 , mouse-lypla1 , mouse-lypla2 |
| Title : Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains - Abrami_2021_Nat.Chem.Biol_17_438 |
| Author(s) : Abrami L , Audagnotto M , Ho S , Marcaida MJ , Mesquita FS , Anwar MU , Sandoz PA , Fonti G , Pojer F , Dal Peraro M , van der Goot FG |
| Ref : Nat Chemical Biology , 17 :438 , 2021 |
| Abstract : |
| PubMedSearch : Abrami_2021_Nat.Chem.Biol_17_438 |
| PubMedID: 33707782 |
| Gene_locus related to this paper: human-LYPLA1 , human-LYPLA2 |
| Title : Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling - Wepy_2019_J.Lipid.Res_60_360 |
| Author(s) : Wepy JA , Galligan JJ , Kingsley PJ , Xu S , Goodman MC , Tallman KA , Rouzer CA , Marnett LJ |
| Ref : J Lipid Res , 60 :360 , 2019 |
| Abstract : |
| PubMedSearch : Wepy_2019_J.Lipid.Res_60_360 |
| PubMedID: 30482805 |
| Gene_locus related to this paper: human-LYPLA2 |
| Title : Human leukocytes differentially express endocannabinoid-glycerol lipases and hydrolyze 2-arachidonoyl-glycerol and its metabolites from the 15-lipoxygenase and cyclooxygenase pathways - Turcotte_2019_J.Leukoc.Biol_106_1337 |
| Author(s) : Turcotte C , Dumais E , Archambault AS , Martin C , Blanchet MR , Bissonnette E , Boulet LP , Laviolette M , Di Marzo V , Flamand N |
| Ref : J Leukoc Biol , 106 :1337 , 2019 |
| Abstract : |
| PubMedSearch : Turcotte_2019_J.Leukoc.Biol_106_1337 |
| PubMedID: 31556464 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-ABHD16A , human-CES1 , human-LYPLA2 , human-PPT1 |
| Title : Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells - Vujic_2016_Oncotarget_7_7297 |
| Author(s) : Vujic I , Sanlorenzo M , Esteve-Puig R , Vujic M , Kwong A , Tsumura A , Murphy R , Moy A , Posch C , Monshi B , Rappersberger K , Ortiz-Urda S |
| Ref : Oncotarget , 7 :7297 , 2016 |
| Abstract : |
| PubMedSearch : Vujic_2016_Oncotarget_7_7297 |
| PubMedID: 26771141 |
| Gene_locus related to this paper: human-LYPLA1 , human-LYPLA2 |
| Title : Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2) - Won_2016_ACS.Chem.Biol_11_3374 |
| Author(s) : Won SJ , Davda D , Labby KJ , Hwang SY , Pricer R , Majmudar JD , Armacost KA , Rodriguez LA , Rodriguez CL , Chong FS , Torossian KA , Palakurthi J , Hur ES , Meagher JL , Brooks CL, 3rd , Stuckey JA , Martin BR |
| Ref : ACS Chemical Biology , 11 :3374 , 2016 |
| Abstract : |
| PubMedSearch : Won_2016_ACS.Chem.Biol_11_3374 |
| PubMedID: 27748579 |
| Gene_locus related to this paper: human-LYPLA1 , human-LYPLA2 |
| Title : Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells - Manna_2014_J.Biol.Chem_289_33741 |
| Author(s) : Manna JD , Wepy JA , Hsu KL , Chang JW , Cravatt BF , Marnett LJ |
| Ref : Journal of Biological Chemistry , 289 :33741 , 2014 |
| Abstract : |
| PubMedSearch : Manna_2014_J.Biol.Chem_289_33741 |
| PubMedID: 25301951 |
| Gene_locus related to this paper: human-LYPLA2 |
| Title : Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2) - Adibekian_2013_Probe.Report__4 |
| Author(s) : Adibekian A , Martin BR , Chang JW , Hsu KL , Tsuboi K , Bachovchin DA , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Cravatt BF , Hodder P , Rosen H |
| Ref : Probe Report , : , 2013 |
| Abstract : |
| PubMedSearch : Adibekian_2013_Probe.Report__4 |
| PubMedID: 24624468 |
| Gene_locus related to this paper: human-LYPLA2 |
| Title : Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M - Rusch_2011_Angew.Chem.Int.Ed.Engl_50_9838 |
| Author(s) : Rusch M , Zimmermann TJ , Burger M , Dekker FJ , Gormer K , Triola G , Brockmeyer A , Janning P , Bottcher T , Sieber SA , Vetter IR , Hedberg C , Waldmann H |
| Ref : Angew Chem Int Ed Engl , 50 :9838 , 2011 |
| Abstract : |
| PubMedSearch : Rusch_2011_Angew.Chem.Int.Ed.Engl_50_9838 |
| PubMedID: 21905186 |
| Gene_locus related to this paper: human-LYPLA1 , human-LYPLA2 |
| Title : Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43 - Tomatis_2010_PLoS.One_5_e15045 |
| Author(s) : Tomatis VM , Trenchi A , Gomez GA , Daniotti JL |
| Ref : PLoS ONE , 5 :e15045 , 2010 |
| Abstract : |
| PubMedSearch : Tomatis_2010_PLoS.One_5_e15045 |
| PubMedID: 21152083 |
| Gene_locus related to this paper: human-LYPLA2 |