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human-LYPLA2

Homo sapiens (Human) acyl-protein thioesterase dJ886K2.4 lysophospholipase II APT2

Comment

another gene human-apthio2 DJ570F3.6 OldTrembl Q9UGE0 Ncbi_pid 6624592 ENSG00000206168 situated very close is a processed pseudo gene

Relationship

Family : LYsophospholipase_carboxylesterase

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

Database

Sequence

Peptide

MCGNTMSVPL LTDAATVSGA ERETAAVIFL HGLGDTGHSW ADALSTIRLP HVKYICPHAP RIPVTLNMKM VMPSWFDLMG LSPDAPEDEA GIKKAAENIK ALIEHEMKNG IPANRIVLGG FSQGGALSLY TALTCPHPLA GIVALSCWLP LHRAFPQAAN GSAKDLAILQ CHGELDPMVP VRFGALTAEK LRSVVTPARV QFKTYPGVMH SSCPQEMAAV KEFLEKLLPP V

References (10)

Title : Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria - Speck_2023_Cell.Rep_42_113389
Author(s) : Speck SL , Bhatt DP , Zhang Q , Adak S , Yin L , Dong G , Feng C , Zhang W , Ben Major M , Wei X , Semenkovich CF
Ref : Cell Rep , 42 :113389 , 2023
Abstract :
PubMedSearch : Speck_2023_Cell.Rep_42_113389
PubMedID: 37925639
Gene_locus related to this paper: human-LYPLA1 , human-LYPLA2 , mouse-lypla1 , mouse-lypla2

Title : Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains - Abrami_2021_Nat.Chem.Biol_17_438
Author(s) : Abrami L , Audagnotto M , Ho S , Marcaida MJ , Mesquita FS , Anwar MU , Sandoz PA , Fonti G , Pojer F , Dal Peraro M , van der Goot FG
Ref : Nat Chemical Biology , 17 :438 , 2021
Abstract :
PubMedSearch : Abrami_2021_Nat.Chem.Biol_17_438
PubMedID: 33707782
Gene_locus related to this paper: human-LYPLA1 , human-LYPLA2

Title : Human leukocytes differentially express endocannabinoid-glycerol lipases and hydrolyze 2-arachidonoyl-glycerol and its metabolites from the 15-lipoxygenase and cyclooxygenase pathways - Turcotte_2019_J.Leukoc.Biol_106_1337
Author(s) : Turcotte C , Dumais E , Archambault AS , Martin C , Blanchet MR , Bissonnette E , Boulet LP , Laviolette M , Di Marzo V , Flamand N
Ref : J Leukoc Biol , 106 :1337 , 2019
Abstract :
PubMedSearch : Turcotte_2019_J.Leukoc.Biol_106_1337
PubMedID: 31556464
Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-ABHD16A , human-CES1 , human-LYPLA2 , human-PPT1

Title : Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling - Wepy_2019_J.Lipid.Res_60_360
Author(s) : Wepy JA , Galligan JJ , Kingsley PJ , Xu S , Goodman MC , Tallman KA , Rouzer CA , Marnett LJ
Ref : J Lipid Res , 60 :360 , 2019
Abstract :
PubMedSearch : Wepy_2019_J.Lipid.Res_60_360
PubMedID: 30482805
Gene_locus related to this paper: human-LYPLA2

Title : Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells - Vujic_2016_Oncotarget_7_7297
Author(s) : Vujic I , Sanlorenzo M , Esteve-Puig R , Vujic M , Kwong A , Tsumura A , Murphy R , Moy A , Posch C , Monshi B , Rappersberger K , Ortiz-Urda S
Ref : Oncotarget , 7 :7297 , 2016
Abstract :
PubMedSearch : Vujic_2016_Oncotarget_7_7297
PubMedID: 26771141
Gene_locus related to this paper: human-LYPLA1 , human-LYPLA2

Title : Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2) - Won_2016_ACS.Chem.Biol_11_3374
Author(s) : Won SJ , Davda D , Labby KJ , Hwang SY , Pricer R , Majmudar JD , Armacost KA , Rodriguez LA , Rodriguez CL , Chong FS , Torossian KA , Palakurthi J , Hur ES , Meagher JL , Brooks CL, 3rd , Stuckey JA , Martin BR
Ref : ACS Chemical Biology , 11 :3374 , 2016
Abstract :
PubMedSearch : Won_2016_ACS.Chem.Biol_11_3374
PubMedID: 27748579
Gene_locus related to this paper: human-LYPLA1 , human-LYPLA2

Title : Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells - Manna_2014_J.Biol.Chem_289_33741
Author(s) : Manna JD , Wepy JA , Hsu KL , Chang JW , Cravatt BF , Marnett LJ
Ref : Journal of Biological Chemistry , 289 :33741 , 2014
Abstract :
PubMedSearch : Manna_2014_J.Biol.Chem_289_33741
PubMedID: 25301951
Gene_locus related to this paper: human-LYPLA2

Title : Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2) - Adibekian_2013_Probe.Report__4
Author(s) : Adibekian A , Martin BR , Chang JW , Hsu KL , Tsuboi K , Bachovchin DA , Speers AE , Brown SJ , Spicer T , Fernandez-Vega V , Ferguson J , Cravatt BF , Hodder P , Rosen H
Ref : Probe Report , : , 2013
Abstract :
PubMedSearch : Adibekian_2013_Probe.Report__4
PubMedID: 24624468
Gene_locus related to this paper: human-LYPLA2

Title : Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M - Rusch_2011_Angew.Chem.Int.Ed.Engl_50_9838
Author(s) : Rusch M , Zimmermann TJ , Burger M , Dekker FJ , Gormer K , Triola G , Brockmeyer A , Janning P , Bottcher T , Sieber SA , Vetter IR , Hedberg C , Waldmann H
Ref : Angew Chem Int Ed Engl , 50 :9838 , 2011
Abstract :
PubMedSearch : Rusch_2011_Angew.Chem.Int.Ed.Engl_50_9838
PubMedID: 21905186
Gene_locus related to this paper: human-LYPLA1 , human-LYPLA2

Title : Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43 - Tomatis_2010_PLoS.One_5_e15045
Author(s) : Tomatis VM , Trenchi A , Gomez GA , Daniotti JL
Ref : PLoS ONE , 5 :e15045 , 2010
Abstract :
PubMedSearch : Tomatis_2010_PLoS.One_5_e15045
PubMedID: 21152083
Gene_locus related to this paper: human-LYPLA2