| Title : Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator - Dotsch_2024_J.Med.Chem__ |
| Author(s) : Dotsch L , Davies C , Hennes E , Schonfeld J , Kumar A , Guita C , Ehrler JHM , Hiesinger K , Thavam S , Janning P , Sievers S , Knapp S , Proschak E , Ziegler S , Waldmann H |
| Ref : Journal of Medicinal Chemistry , : , 2024 |
| Abstract : |
| PubMedSearch : Dotsch_2024_J.Med.Chem__ |
| PubMedID: 38470246 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Boron-based inhibitors of acyl protein thioesterases 1 and 2 - Zimmermann_2013_Chembiochem_14_115 |
| Author(s) : Zimmermann TJ , Burger M , Tashiro E , Kondoh Y , Martinez NE , Gormer K , Rosin-Steiner S , Shimizu T , Ozaki S , Mikoshiba K , Watanabe N , Hall D , Vetter IR , Osada H , Hedberg C , Waldmann H |
| Ref : Chembiochem , 14 :115 , 2013 |
| Abstract : |
| PubMedSearch : Zimmermann_2013_Chembiochem_14_115 |
| PubMedID: 23239555 |
| Title : Crystal structure of the predicted phospholipase LYPLAL1 reveals unexpected functional plasticity despite close relationship to acyl protein thioesterases - Burger_2012_J.Lipid.Res_53_43 |
| Author(s) : Burger M , Zimmermann TJ , Kondoh Y , Stege P , Watanabe N , Osada H , Waldmann H , Vetter IR |
| Ref : J Lipid Res , 53 :43 , 2012 |
| Abstract : |
| PubMedSearch : Burger_2012_J.Lipid.Res_53_43 |
| PubMedID: 22052940 |
| Gene_locus related to this paper: human-LYPLAL1 |
| Title : Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M - Rusch_2011_Angew.Chem.Int.Ed.Engl_50_9838 |
| Author(s) : Rusch M , Zimmermann TJ , Burger M , Dekker FJ , Gormer K , Triola G , Brockmeyer A , Janning P , Bottcher T , Sieber SA , Vetter IR , Hedberg C , Waldmann H |
| Ref : Angew Chem Int Ed Engl , 50 :9838 , 2011 |
| Abstract : |
| PubMedSearch : Rusch_2011_Angew.Chem.Int.Ed.Engl_50_9838 |
| PubMedID: 21905186 |
| Gene_locus related to this paper: human-LYPLA1 , human-LYPLA2 |
| Title : Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design - Hedberg_2011_Angew.Chem.Int.Ed.Engl_50_9832 |
| Author(s) : Hedberg C , Dekker FJ , Rusch M , Renner S , Wetzel S , Vartak N , Gerding-Reimers C , Bon RS , Bastiaens PI , Waldmann H |
| Ref : Angew Chem Int Ed Engl , 50 :9832 , 2011 |
| Abstract : |
| PubMedSearch : Hedberg_2011_Angew.Chem.Int.Ed.Engl_50_9832 |
| PubMedID: 21905185 |
| Title : Small-molecule inhibition of APT1 affects Ras localization and signaling - Dekker_2010_Nat.Chem.Biol_6_449 |
| Author(s) : Dekker FJ , Rocks O , Vartak N , Menninger S , Hedberg C , Balamurugan R , Wetzel S , Renner S , Gerauer M , Scholermann B , Rusch M , Kramer JW , Rauh D , Coates GW , Brunsveld L , Bastiaens PI , Waldmann H |
| Ref : Nat Chemical Biology , 6 :449 , 2010 |
| Abstract : |
| PubMedSearch : Dekker_2010_Nat.Chem.Biol_6_449 |
| PubMedID: 20418879 |
| Gene_locus related to this paper: human-LYPLA1 |
| Title : A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis - Siegel_2009_Nat.Cell.Biol_11_705 |
| Author(s) : Siegel G , Obernosterer G , Fiore R , Oehmen M , Bicker S , Christensen M , Khudayberdiev S , Leuschner PF , Busch CJ , Kane C , Hubel K , Dekker F , Hedberg C , Rengarajan B , Drepper C , Waldmann H , Kauppinen S , Greenberg ME , Draguhn A , Rehmsmeier M , Martinez J , Schratt GM |
| Ref : Nat Cell Biol , 11 :705 , 2009 |
| Abstract : |
| PubMedSearch : Siegel_2009_Nat.Cell.Biol_11_705 |
| PubMedID: 19465924 |
| Gene_locus related to this paper: human-LYPLA1 |
| Title : Protein structure similarity clustering and natural product structure as guiding principles for chemical genomics - Koch_2006_Ernst.Schering.Res.Found.Workshop__89 |
| Author(s) : Koch MA , Waldmann H |
| Ref : Ernst Schering Res Found Workshop , :89 , 2006 |
| Abstract : |
| PubMedSearch : Koch_2006_Ernst.Schering.Res.Found.Workshop__89 |
| PubMedID: 16709001 |
| Title : Synthesis and evaluation of acyl protein thioesterase 1 (APT1) inhibitors - Biel_2006_Chemistry_12_4121 |
| Author(s) : Biel M , Deck P , Giannis A , Waldmann H |
| Ref : Chemistry , 12 :4121 , 2006 |
| Abstract : |
| PubMedSearch : Biel_2006_Chemistry_12_4121 |
| PubMedID: 16528788 |
| Title : Protein domain fold similarity and natural product structure as guiding principles for compound library design - |
| Author(s) : Koch MA , Waldmann H |
| Ref : Ernst Schering Res Found Workshop , :1 , 2005 |
| PubMedID: 15645714 |
| Title : Development and biological evaluation of acyl protein thioesterase 1 (APT1) inhibitors - |
| Author(s) : Deck P , Pendzialek D , Biel M , Wagner M , Popkirova B , Ludolph B , Kragol G , Kuhlmann J , Giannis A , Waldmann H |
| Ref : Angew Chem Int Ed Engl , 44 :4975 , 2005 |
| PubMedID: 16003812 |
| Title : Compound library development guided by protein structure similarity clustering and natural product structure - Koch_2004_Proc.Natl.Acad.Sci.U.S.A_101_16721 |
| Author(s) : Koch MA , Wittenberg LO , Basu S , Jeyaraj DA , Gourzoulidou E , Reinecke K , Odermatt A , Waldmann H |
| Ref : Proc Natl Acad Sci U S A , 101 :16721 , 2004 |
| Abstract : |
| PubMedSearch : Koch_2004_Proc.Natl.Acad.Sci.U.S.A_101_16721 |
| PubMedID: 15548605 |
| Title : Protein structure similarity as guiding principle for combinatorial library design - Koch_2003_Biol.Chem_384_1265 |
| Author(s) : Koch MA , Breinbauer R , Waldmann H |
| Ref : Biol Chem , 384 :1265 , 2003 |
| Abstract : |
| PubMedSearch : Koch_2003_Biol.Chem_384_1265 |
| PubMedID: 14515987 |
| Title : Enzymatic protecting group techniques for glyco- and phosphopeptide chemistry: synthesis of a glycophosphopeptide from human serum response factor - Sander_2000_Chemistry_6_1564 |
| Author(s) : Sander J , Waldmann H |
| Ref : Chemistry , 6 :1564 , 2000 |
| Abstract : |
| PubMedSearch : Sander_2000_Chemistry_6_1564 |
| PubMedID: 10839174 |