Tang_2014_Nat.Genet_46_261

Reference

Title : Genome of the human hookworm Necator americanus - Tang_2014_Nat.Genet_46_261
Author(s) : Tang YT , Gao X , Rosa BA , Abubucker S , Hallsworth-Pepin K , Martin J , Tyagi R , Heizer E , Zhang X , Bhonagiri-Palsikar V , Minx P , Warren WC , Wang Q , Zhan B , Hotez PJ , Sternberg PW , Dougall A , Gaze ST , Mulvenna J , Sotillo J , Ranganathan S , Rabelo EM , Wilson RK , Felgner PL , Bethony J , Hawdon JM , Gasser RB , Loukas A , Mitreva M
Ref : Nat Genet , 46 :261 , 2014
Abstract :

The hookworm Necator americanus is the predominant soil-transmitted human parasite. Adult worms feed on blood in the small intestine, causing iron-deficiency anemia, malnutrition, growth and development stunting in children, and severe morbidity and mortality during pregnancy in women. We report sequencing and assembly of the N. americanus genome (244 Mb, 19,151 genes). Characterization of this first hookworm genome sequence identified genes orchestrating the hookworm's invasion of the human host, genes involved in blood feeding and development, and genes encoding proteins that represent new potential drug targets against hookworms. N. americanus has undergone a considerable and unique expansion of immunomodulator proteins, some of which we highlight as potential treatments against inflammatory diseases. We also used a protein microarray to demonstrate a postgenomic application of the hookworm genome sequence. This genome provides an invaluable resource to boost ongoing efforts toward fundamental and applied postgenomic research, including the development of new methods to control hookworm and human immunological diseases.

PubMedSearch : Tang_2014_Nat.Genet_46_261
PubMedID: 24441737
Gene_locus related to this paper: necam-w2tsu7

Related information

Gene_locus necam-w2tsu7
Gene_locus_frgt necam-w2tsu7    necam-w2ti88    necam-w2tkc2

Citations formats

Tang YT, Gao X, Rosa BA, Abubucker S, Hallsworth-Pepin K, Martin J, Tyagi R, Heizer E, Zhang X, Bhonagiri-Palsikar V, Minx P, Warren WC, Wang Q, Zhan B, Hotez PJ, Sternberg PW, Dougall A, Gaze ST, Mulvenna J, Sotillo J, Ranganathan S, Rabelo EM, Wilson RK, Felgner PL, Bethony J, Hawdon JM, Gasser RB, Loukas A, Mitreva M (2014)
Genome of the human hookworm Necator americanus
Nat Genet 46 :261

Tang YT, Gao X, Rosa BA, Abubucker S, Hallsworth-Pepin K, Martin J, Tyagi R, Heizer E, Zhang X, Bhonagiri-Palsikar V, Minx P, Warren WC, Wang Q, Zhan B, Hotez PJ, Sternberg PW, Dougall A, Gaze ST, Mulvenna J, Sotillo J, Ranganathan S, Rabelo EM, Wilson RK, Felgner PL, Bethony J, Hawdon JM, Gasser RB, Loukas A, Mitreva M (2014)
Nat Genet 46 :261