Venkataraman_1994_Ind.J.Physiol.Pharmacol_38_214

Reference

Title : Correlation of time course of blood cholinesterase activity and toxic manifestations of acute methylparathion in antidote treated rats - Venkataraman_1994_Ind.J.Physiol.Pharmacol_38_214
Author(s) : Venkataraman BV , Rani MA , Andrade C , Joseph T
Ref : Indian Journal of Physiology & Pharmacology , 38 :214 , 1994
Abstract : Study was conducted to find out the correlation between red blood cholinesterase (RBC ChE) and plasma butyryl cholinesterase (BCHE) activities and toxic signs of oral methylparathion (MPT) and their recovery pattern with or without atropine treatment in female rats. Enzyme activity was estimated before and after an oral dose of MPT (7.5 mg/kg-1) at various time intervals upto 120 hr. Antidote groups received atropine (10 mg/kg-1, i.p.), either alone or with diazepam (2.5 mg/kg-1, i.p.), at the onset of toxic signs. Inhibition of enzyme activity served as definite index of acute toxicity of MPT. RBC ChE activity correlated with the intensity of toxic signs in no-antidote rats, while in atropine treated groups, there was no correlation. BCHE levels did not correlate with toxic signs in any of the groups except in the fatal group. The resynthesis of both the enzymes was complete in 120 hr study and did not synchronize with the recovery pattern of animals from toxic signs. Compared to BCHE, RBC ChE activity was found to be a more sensitive indicator for the diagnosis of severity of MPT toxicity.
ESTHER : Venkataraman_1994_Ind.J.Physiol.Pharmacol_38_214
PubMedSearch : Venkataraman_1994_Ind.J.Physiol.Pharmacol_38_214
PubMedID: 7814086

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Citations formats

Venkataraman BV, Rani MA, Andrade C, Joseph T (1994)
Correlation of time course of blood cholinesterase activity and toxic manifestations of acute methylparathion in antidote treated rats
Indian Journal of Physiology & Pharmacology 38 :214

Venkataraman BV, Rani MA, Andrade C, Joseph T (1994)
Indian Journal of Physiology & Pharmacology 38 :214